📄 Category

medicine

3171 papers

📄 medicine

Dyslipidemia and risk of incident stroke: the mediating role of insulin resistance assessed by the triglyceride–glucose index in the CHARLS cohort

In a cohort of Chinese adults aged 45 and older, insulin resistance assessed by the triglyceride–glucose (TyG) index was found to partially mediate the association between dyslipidemia (specifically total cholesterol and HDL-C) and incident stroke risk, suggesting TyG serves as a useful adjunct marker for metabolic risk assessment beyond traditional LDL-C measures.

Yiming Huang, Xi Chen, Yujia Yan, Yang Zhang, Ming Li, Xunming Ji2026-07-14
📄 medicine

Establishing Zambia's First National Malaria RDT Proficiency Testing Programme: A Model for Strengthening Sustainable Diagnostic Capacity through South-to-South Collaboration

Through a South–South collaboration with Uganda facilitated by ECSA-HC, Zambia successfully established its first national malaria RDT proficiency testing programme, demonstrating that peer-learning models can rapidly build sustainable, high-performing diagnostic quality assurance systems aligned with regional public health goals.

Doreen Mainza Shempela, Cynthia Kasonde, Moonga Hawela, Mike Masona, Jacob Chirwa, Andrew Mwandila, Mutinta Chonga, Mais (…)2026-07-14
📄 medicine

Rational design of short hybrid Cecropin B/Aurein 1.2 peptide analogues: in vitro synergistic anti-MRSA and anti-biofilm activities

Rationally designed short hybrid peptide Cec-Aur 1 demonstrates potent, low-toxicity anti-MRSA and anti-biofilm activities, including significant synergy with oxacillin and effective wound healing in a murine infection model, positioning it as a promising therapeutic candidate against multidrug-resistant *Staphylococcus aureus*.

Maryam Ghahramani, Mohammad Aghazadeh, Javid Sadeghi, Vahdat Poortahmasebi, Amin Abdollahzade-Fard, Mahdieh Delfi, Paris (…)2026-07-14
📄 medicine

Clinical Application of a Dual-Threshold Bolus Tracking Protocol in One-Stop Combined CT Angiography and Venography of the Lower Extremities: A Prospective Comparative Observational Study

This prospective comparative study demonstrates that a personalized dual-threshold bolus tracking protocol significantly improves venous image quality and diagnostic yield in one-stop lower extremity CTA-CTV compared to a fixed-delay approach, while maintaining equivalent arterial enhancement and radiation dose.

Qing-Peng Zhan, Shang-Ao Gong, Yu-Long Xie, Ting Wang, Hao Zhou, Chang-Zheng Shi2026-07-14
📄 medicine

Prevalence and characteristics of enamel hypomineralisation in permanent teeth among orthodontic patients aged 8 to 18 years: a retrospective study.

This retrospective study of 361 orthodontic patients aged 8 to 18 found that molar incisor hypomineralisation (MIH) has a 24.9% prevalence and is strongly associated with hypomineralisation in other permanent teeth and enamel hypoplasia, highlighting the need for early monitoring of non-index teeth in affected children.

Cung May Thai, Gwen Feenstra, David John Manton, Isabel Cristina Olegário, Clarissa Calil Bonifacio2026-07-14
📄 medicine

Chronic Illness and Impoverishment in Urban Bangladesh: Evidence from Household Income and Expenditure Survey 2022

Using 2022 Household Income and Expenditure Survey data, this study reveals that chronic illness and Out-of-Pocket healthcare spending in urban Bangladesh create a vicious cycle where households are significantly more likely to fall into poverty due to medical costs, while poverty simultaneously increases the risk of chronic illness.

Azima Begum, Muhammad Shahadat Hossain Siddiquee2026-07-14
📄 medicine

Antibiotic trajectories after cardiopulmonary bypass and in-hospital mortality across critical care databases

This multi-database cohort study demonstrates that specific postoperative antibiotic trajectories, particularly persistent broad-spectrum therapy and late escalation, are reproducible prognostic markers of increased in-hospital mortality in cardiopulmonary bypass patients, outperforming conventional binary exposure definitions.

Ding Zhang, Ru-qin Yi, Wei Chen, Cheng-en Li, Zhi-rong Zhang, Ying-ying Shen, Zhao-kun Fan2026-07-14
📄 medicine

Joint Associations of Anthropometric Indices and the Cholesterol– High‑Density Lipoprotein–Glucose Index with Collateral Circulation Formation in Patients with Chronic Total Occlusion of Coronary Arteries: A Cross‑Sectional Study

This cross-sectional study of 841 patients with chronic total occlusion reveals that cholesterol–high-density lipoprotein–glucose (CHG) modified anthropometric indices, particularly CHG-ABSI and CHG-WWI, are strongly and independently associated with poor collateral circulation formation, outperforming the CHG index alone in identifying patients with an adverse metabolic-adiposity phenotype.

Xueyu Lv, Junqi Yu, Xiaoyan Lu, Zhihang Du, Dan Li2026-07-14
📄 medicine

Molecular spectrum and genotype-phenotype correlations in Romanian patients with neurofibromatosis type 1

This study characterizes the molecular spectrum and genotype-phenotype correlations in 162 Romanian patients with neurofibromatosis type 1, revealing 17 novel variants, significant phenotypic variability even among individuals with identical genotypes, and the importance of comprehensive genomic testing for identifying dual diagnoses and guiding multidisciplinary surveillance.

Teodora Toc, Nicoleta Ioana Andreescu, Catalin Vasile Munteanu, Iulia-Elena Simina, Florina Stoica, Aurora Alexandra Jur (…)2026-07-14