📄 Category

medicine

3171 papers

📄 medicine

Feasibility of a primary care-based adapted physical activity program for older adults with chronic conditions: the CAPA-CITY 70 pilot study

The CAPA-CITY 70 pilot study demonstrates that a primary care-based, supervised adapted physical activity program is feasible and highly acceptable for community-dwelling adults aged 70 and older with chronic conditions, achieving high completion and adherence rates while supporting the need for larger controlled trials to assess long-term effectiveness.

Emile Escourrou, Thomas Richaud, Aurore Palmaro, Bruno Chicoulaa, Sandrine Andrieu, Stéphane Oustric2026-07-14
📄 medicine

Impact of catheter-induced flow compromise on the presence of multiple ischemic lesions in endovascular treatment of posterior circulation aneurysms: a two-center retrospective study

This two-center retrospective study of 108 patients demonstrates that catheter-induced flow compromise, driven primarily by vertebral artery tortuosity and including both complete wedges and incomplete flow stasis, is a strong independent predictor of multiple new ischemic lesions following endovascular treatment of posterior circulation aneurysms, underscoring the need for rigorous preoperative anatomical assessment and intraprocedural risk-avoidance strategies.

Nagatsuki Tomura, Kento Asakura, Tomoyuki Tsumoto, Fukutaro Ohgaki, Jo Sasame, Shigeo Matsunaga, Takashi Shuto2026-07-14
📄 medicine

Emergency Presentations and Predictors of Adverse Outcomes in Systemic Lupus Erythematosus: A Retrospective Cohort Study

This retrospective cohort study of 50 SLE patients presenting to the emergency department found that while immunological markers and complement depletion are associated with severe disease, the clinical severity of the presentation itself is the strongest predictor of ICU admission and mortality.

Emad Elshebiny, Ahmed Shaltoot, Amr Hussien Ahmed Zaki, Enas Sobhy Zahran, Athar Fekry Lasheen, Mohammed Khalil, Mohamed (…)2026-07-14
📄 medicine

Early Physiological Trajectory-Based Phenotyping in Surgical Intensive Care Unit Patients: A Gaussian Mixture Modeling Approach Integrating Temperature, Central Venous Pressure, Fluid Balance, and Glycemic Dynamics

This retrospective study utilized Gaussian Mixture Modeling on the first 72 hours of multidimensional physiological data from 3,493 surgical ICU patients to identify five distinct trajectory phenotypes that reveal clinically meaningful subgroups with varying disease severity and resource utilization patterns, including a unique high-risk, zero-mortality group characterized by advanced age and compensated physiology.

Sai Chen, Jin Li, Yanping Kuang, Xuan Dai, Hongyan Wei, Yongjun Liu, Chunlin Hu2026-07-14
📄 medicine

A Dual-Phase Multimodal Transformer Integrating Pre- and Post-Thrombectomy Computed Tomography and Clinical Features to Predict 90-Day Functional Outcome After Mechanical Thrombectomy

This study developed and externally validated a dual-phase multimodal Transformer model that integrates pre- and post-thrombectomy CT images with clinical features to accurately predict unfavorable 90-day functional outcomes in acute ischemic stroke patients who exhibit immediate post-procedural cerebral hyperdensity, outperforming standalone models and enhancing physician prognostic accuracy.

Jiahong Fu, Yuhan Chen, YUjie Shen, Jiayi Hong, Shiying Gai, Huan Liu, Yan Li, Lina Jiang, Xiaochao Yu, Dekuai Tong, Son (…)2026-07-14
📄 medicine

Dinutuximab beta-based first-line maintenance therapy for newly diagnosed high-risk neuroblastoma following a COG-based pathway: a single-center real-world study in China

This single-center Chinese study demonstrates the feasibility and safety of implementing a COG-based pathway for newly diagnosed high-risk neuroblastoma followed by dinutuximab beta maintenance, reporting a 3-year event-free survival of 69.2% with manageable toxicity profiles and highlighting the importance of cycle-stratified safety analysis and monitoring for CNS-related relapses.

Meng Yi, Senmin Chen, Huanli Xu, Chao Liu, Huiping Lang, Xiuli Yuan2026-07-14
📄 medicine

White Matter Hyperintensity Burden Is Associated With Altered Functional Network Topology and Enhanced Structural-Functional Coupling in Cerebral Small Vessel Disease

This study demonstrates that in patients with cerebral small vessel disease, a higher burden of white matter hyperintensities is associated with altered functional network topology characterized by increased local segregation and enhanced structural-functional coupling, suggesting that white matter injury drives brain network reorganization and may serve as a key imaging marker for disease severity.

Fan Yang, Hanjiaerbieke Kukun, Xiang Tan, Tao Xiong, Chao Guo2026-07-14