13473 papers
This mini-meta-analysis of two randomized, double-blind, placebo-controlled trials demonstrates that adjunctive stiripentol significantly reduces clonic and generalized tonic-clonic seizure frequency in patients with Dravet syndrome while maintaining a favorable safety and tolerability profile.
In patients undergoing total hip arthroplasty for displaced femoral neck fractures, local infiltration analgesia with liposomal bupivacaine significantly reduced early postoperative pain and opioid consumption compared to no infiltration, but adding tranexamic acid and flurbiprofen axetil provided no additional analgesic benefit.
This cross-sectional study in eastern Uganda reveals a high prevalence (64.1%) of pubertal delay among children and adolescents with sickle cell disease, identifying male sex, taller stature, and higher fruit intake as protective factors while noting that treatment status was paradoxically associated with increased odds of delay.
This single-centre retrospective study comparing robotic preperitoneal extended totally extraperitoneal (rPeTEP) and robotic transabdominal preperitoneal (rTAPP) repairs for primary midline ventral hernias found that while both techniques are safe and feasible, rPeTEP offers the advantage of reduced early postoperative pain and suitability for extensive rectus divarication, whereas rTAPP demonstrates a shorter learning curve and better accommodates concomitant intra-abdominal procedures.
This study provides preliminary psychometric evidence that the 10-item clinician-rated NMSS-OFF/ON scale is a valid, internally consistent, and highly responsive instrument for assessing non-motor fluctuations in Parkinson's disease, though larger independent studies are needed to fully establish its structural validity and clinical thresholds.
While health profession students and disaster response organizations in Germany both express high willingness to integrate students into emergency surge capacity, their specific task expectations diverge significantly, with students favoring patient-facing acute care and organizations prioritizing logistical and nursing support, highlighting a critical need to align these perspectives through targeted training and insurance frameworks.
A five-day community-based immersion program significantly improved second-year medical students' attitudes toward people with disabilities, reduced their discomfort, and enhanced their perceived social competence and coping skills, highlighting the value of direct interaction in medical education while suggesting the need for broader, longitudinal curriculum integration.
In a prospective multicenter single-arm trial involving 97 patients, the novel LeesCa™ balloon angiographic catheter demonstrated 100% device success and a 98.97% procedural success rate with a low adverse event profile, confirming its safety and efficacy for coronary venography during left ventricular lead implantation for cardiac resynchronization therapy.
This retrospective cohort study of the US National Trauma Database (2017–2020) reveals that while nonoperative management is the predominant approach for pediatric pancreatic trauma, operative management is associated with significantly longer hospital and ICU stays but lower mortality rates, supporting the need for individualized treatment strategies.
A high-throughput screen identified the proteasome inhibitor ixazomib citrate as a promising therapeutic strategy that selectively targets and inhibits the growth of ALK-mutant neuroblastoma tumors both in vitro and in vivo.