3171 papers
This retrospective study of 190 acute pancreatitis patients demonstrates that a 48-hour procalcitonin (PCT) level exceeding 0.23 ng/mL is a superior independent predictor of pancreatic necrosis compared to traditional scoring systems and other biomarkers, offering a rapid and effective tool for early clinical identification.
This retrospective cohort study of 205 maintenance hemodialysis patients demonstrates that aortic arch calcification scores derived from routine chest CT scans are independent predictors of both cardiovascular and all-cause mortality, offering a promising tool for risk stratification in this population.
This study utilizing the SEER database and validated by a single-center cohort identifies tumor size as an independent prognostic factor for survival in pediatric and adolescent patients with malignant peripheral nerve sheath tumors, establishing an optimal age-stratified cutoff of approximately 5.75 cm for risk stratification.
This propensity score-matched cross-sectional study reveals that in Type 2 diabetes patients with osteoporosis, bone turnover markers are comparable to those in pure diabetes, challenging the classic low-turnover hypothesis, while distinct PTH suppression with mild hypercalcemia and a weakened glycemic-bone turnover correlation suggest unique alterations in calcium homeostasis and metabolic regulation.
This study demonstrates that polyethyleneimine-coated Ligustrazine-loaded liposomes, developed via thin-film hydration and validated through molecular docking and in vivo rat models, effectively target the kidneys and mitigate acetaminophen-induced nephrotoxicity, offering a promising drug repurposing strategy for treating kidney damage.
This cross-sectional study of Turkish dental students reveals that while clinical training significantly improves both self-reported oral health attitudes and objective periodontal status, a marked discordance exists between the two measures, particularly regarding gender-specific improvements in clinical findings that are not reflected in self-reported behaviors.
This case-control study of nearly 10,000 participants across nine Latin American countries identifies several modifiable environmental risk factors for Parkinson's disease, including pesticide and metal exposure, rural living, well water consumption, and head trauma, while confirming protective effects of caffeine and tobacco, collectively accounting for an estimated 13.7% of the disease burden in the region.
The paper proposes SINÚ-CCUM, an integrated community-based intervention for Montería, Colombia, that addresses geographical, sociocultural, administrative, and operational barriers to cervical cancer screening by training a multidisciplinary team and establishing a simplified diagnostic pathway coordinated among key health stakeholders.
This retrospective study of 8,413 patients across five rural Vision Centres in Karnataka, India, demonstrates that over a 12-month period, these facilities effectively detected refractive errors leading to a 29% spectacle conversion rate, facilitated 1,720 cataract surgeries, and integrated systemic disease screening for over 2,400 individuals.
Manganese dioxide (MnO₂) nanomaterials enhance anti-tumor immunity by chelating excess extracellular potassium in the tumor microenvironment, thereby reversing high-K⁺-induced metabolic dysfunction and aberrant TCF7 upregulation to restore the normal function of stem-like CD8⁺ T cells.