📄 medicine

Moral Distress and Associated Factors Among Nurses Working at Government Hospitals in Dessie City Administration, Northeast Ethiopia

This 2024 cross-sectional study of 355 nurses in Dessie City, Ethiopia, found a high prevalence (66.5%) of moral distress significantly associated with factors such as perceived powerlessness, lack of confidence in decision-making, inadequate staffing, weak organizational support, and job dissatisfaction.

Jemal Mohammed Bahru, Honelet Debebe Dagne, Mohammed Mechal Adem2026-10-19
📄 medicine

Mefloquine Prophylaxis Results and Evaluation of adVerse Effects iN Peacekeepers Travelling to South Sudan: Mefloquine PREVENT–SS Study

This retrospective study of Indian UN peacekeepers in South Sudan demonstrates that consistent adherence to Mefloquine prophylaxis significantly reduces malaria risk, though fear of and experience with neuropsychiatric adverse effects remain the primary barriers to compliance.

Abhinav Kumar, Dheeraj Uppaluri, Deepak Sharma, Ankita Patel, Amit Sharma, P. Basavaraj2026-10-19
📄 medicine

Ethical tensions experienced by healthcare professionals in supportive cancer care: a qualitative study proposing a classification

This qualitative study identifies and classifies ethical tensions experienced by healthcare professionals in supportive cancer care into non-dilemmatic and dilemmatic categories, proposing the PTR (Patient, Temporality, Resources) model as a diagnostic tool to address the recurrent causes of these tensions and improve access to care.

Soumya Anane-Abrous, Philippe Tessier, Guillaume Durand, Isabelle Cojean-Zelek2026-10-19
📄 medicine

Identical results, hidden data problems: running CMS's digital quality measures on real hospital data

This study demonstrates that while CMS's digital quality measures for severe hypoglycemia and hyperglycemia can be executed efficiently and consistently on real hospital data using FHIR, the resulting metrics are highly sensitive to underlying data quality issues—such as missing units and admission status classifications—rather than execution engine errors, underscoring the critical need for data readiness testing before mandatory FHIR reporting.

Sai Sharan Kasa2026-10-19
📄 medicine

Functional epigenomic liquid biopsy identifies potential therapeutic vulnerabilities after enfortumab vedotin–pembrolizumab resistance in metastatic urothelial carcinoma (mUC)

This study demonstrates that longitudinal functional epigenomic liquid biopsy using H3K4me2 cfChIP-seq can identify dynamic regulatory reprogramming and emerging therapeutic vulnerabilities, such as ERBB2 activation, in metastatic urothelial carcinoma patients developing resistance to enfortumab vedotin–pembrolizumab, thereby offering a strategy to guide subsequent biomarker-driven treatment.

Joaquim Bellmunt, Rong Li, Sara El Sarout, Yingtian Xie, Gunsagar Gulati, Ilana Epstein, Shweta Kukreja, Luisa Rodriguez (…)2026-10-19
📄 medicine

Measuring health facility readiness for obstetric fistula surgery and care in Busoga sub-region, eastern Uganda: Development of scoring criteria/framework for facility readiness and application to six hospitals in the region

This study developed and applied a consensus-based seven-domain scoring framework to assess six hospitals in eastern Uganda, revealing that only one facility met the readiness threshold for routine obstetric fistula surgery due primarily to critical deficits in specialized human resources, equipment, and clinical protocols.

Peter Kivunike Mukasa, Mary Kinney, Steven Katende, Wilberforce Mugwanya, Abdmagidu Menya, Smule Kizza Sajjabi, Alison E (…)2026-10-19
📄 medicine

The NT-proBNP/hs-cTnT Ratio Identifies Distinct Hemodynamic Phenotypes in Wild-type Transthyretin Cardiac Amyloidosis: a multicenter Italian study

This multicenter Italian study demonstrates that the NT-proBNP/hs-cTnT ratio stratifies patients with wild-type transthyretin cardiac amyloidosis into three distinct hemodynamic phenotypes characterized by progressively worsening cardiac function, renal impairment, and atrial fibrillation prevalence.

Federica Bellini, Daniela Di Lisi, Emilio Nardi, Carola Maria Gagliardo, Gabriele Di Gesaro, Antonina Giammanco, Lucio T (…)2026-10-19
📄 medicine

Simulation-Based Ultrasound Training and Clinical Performance in Obstetric Residents: A Prospective Controlled Exploratory Pilot Study

This prospective controlled pilot study suggests that six weeks of structured simulation-based training improves clinical ultrasound performance and technical skills in obstetric residents compared to routine training, although the results did not reach statistical significance due to the small sample size.

Livia Schuler, Sara Ardabili, Markus Hodel, Benedict Krischer2026-10-19