13473 papers
This paper reports a rare case of adenosquamous carcinoma of the colon with a mismatch repair deficiency profile complicated by a granular MLH1 staining artifact, highlighting the critical need to recognize such patterns to avoid misdiagnosis and ensure accurate therapeutic decision-making.
In a large cohort of Chinese very-old adults, baseline natural tooth count was not independently associated with incident dementia, whereas denture use and activities of daily living limitations emerged as significant prognostic factors for dementia risk.
Using data from the China Health and Retirement Longitudinal Study (2011–2018), this study reveals that employment-type inequalities significantly shape healthy working life expectancy among older Chinese adults, with agricultural workers facing the highest burden of unhealthy work, particularly women, suggesting that retirement reforms must account for these disparities rather than relying solely on average longevity.
This cost-utility analysis of pneumococcal vaccination strategies for older adults in the Philippines concludes that while sequential PCV13/PPV23 and PCV15/PPV23 regimens offer additional health benefits, PPV23 alone is the most cost-effective and budget-saving option, yielding the lowest incremental cost-effectiveness ratio and net cost savings compared to no vaccination.
This computational study demonstrates that optimizing left ventricular assist device (LVAD) outcomes requires balancing the competing effects of outflow graft angle, pulsatile support, and native cardiac recovery on aortic hemodynamics, blood washout, and hemocompatibility.
This paper presents and preliminarily validates a computationally efficient, non-invasive 4D ultrasound framework that identifies patient-specific anisotropic mechanical properties of abdominal aortic aneurysm walls by solving an inverse finite element problem, demonstrating strong agreement with mechanical testing in both porcine and human tissues.
In a surgeon-stratified retrospective cohort study of 100 patients undergoing retrosigmoid resection of large vestibular schwannomas, initial cerebrospinal fluid release via the lateral cerebellomedullary cistern was associated with significantly shorter operative times, fewer postoperative cerebellar diffusion-weighted imaging abnormalities, and reduced dizziness compared to cisterna magna access, though the non-protocolized selection limits causal conclusions.
This prospective cohort study demonstrates that early upregulation of PD-1 and CTLA-4 expression on peripheral T cells, particularly the proportion of CD4+ PD-1+ T cells, is strongly associated with the development of chronic critical illness and 28-day mortality in critically ill adults, suggesting these immune checkpoints serve as promising biomarkers for early risk stratification.
This study demonstrates that augmenting deep neural network embeddings with physiological descriptors significantly improves cross-database electrocardiogram beat classification performance under unseen domain shifts, offering a robust solution for generalizing models across different institutions and devices without target-domain adaptation.
This descriptive analysis of 2022–2024 vaccination data in the greater Paris Region demonstrates that community pharmacists significantly expanded their role in administering and prescribing vaccines, particularly for influenza and newly recommended immunizations like HPV and pertussis, thereby highlighting their critical responsiveness to updated schedules and epidemic situations.