📄 Category

medicine

3171 papers

📄 medicine

Clinical significance of the timing of high-output stoma onset after ileostomy: Association with stoma outlet obstruction and length of hospital stay

This prospective multicenter study reveals that while the incidence of stoma outlet obstruction (SOO) increases with the timing of high-output stoma onset, late-onset high-output stoma (occurring on or after postoperative day 6) serves as a highly specific clinical indicator of underlying SOO rather than a sensitive screening marker, correlating with significantly longer hospital stays.

Takuya Shiraishi, Yuji Nishizawa, Mifumi Nakajima, Ryoko Kado, Hiroomi Ogawa, Naomi Satoh, Yohei Owada, Tsuyoshi Enomoto (…)2026-07-14
📄 medicine

Parkinsonism-hyperpyrexia syndrome following globus pallidus internus deep brain stimulation withdrawal: a report of two cases and literature review

This paper reports two cases of Parkinsonism-hyperpyrexia syndrome triggered by globus pallidus internus deep brain stimulation withdrawal, highlighting that while hyperthermia resolves rapidly upon device reactivation, creatine kinase levels remain elevated for days, necessitating continued biochemical monitoring to prevent premature de-escalation of care.

Ketai Lin, Huishan Cha, Juntao Chen, Yingwang Yuan, Xiang Lv, Xinyu Zhang, Kaiyue Su, Yanghong Zou, Xin Geng2026-07-14
📄 medicine

New coumarin-piperazine derivatives alleviate inflammatory bowel diseases as IL-6 inhibitors by targeting NF-κB pathway

This study demonstrates that newly synthesized coumarin-piperazine derivatives, particularly compound 4s, effectively alleviate inflammatory bowel disease by inhibiting the NF-κB pathway to reduce IL-6 expression, thereby mitigating intestinal inflammation with low toxicity.

Tian-Fen Liu, Rui-Juan Yang, Mao-Song Wu, Ye Liu, Zi-Tong Wang, Chun-Yan Hu, Ze-Wei Mao2026-07-14
📄 medicine

Escitalopram Adverse Events in Real-World Databases: Signal Detection, Prediction Modeling, and Network Toxicology

This study utilized real-world databases (FAERS and JADER) to detect significant escitalopram-related suicide risk signals, identified serotonergic and dopaminergic pathways as underlying molecular mechanisms, and demonstrated that machine learning models for predicting adverse events require region-specific retraining to maintain accuracy across different populations.

Shiyu Wang, Qingmao Luo, Qianni Pan, Cuiyu Li, Yu Zou, Jiahao Chen, Wenyan Yi2026-07-14
📄 medicine

Technical and Scale Efficiency of Secondary-Level Hospitals in Ethiopia: A Data Envelopment Analysis

A Data Envelopment Analysis of 12 secondary-level hospitals in Ethiopia reveals widespread technical and scale inefficiencies, indicating that these facilities could reduce inputs by 34% and increase outputs by 85% without compromising service levels, potentially saving 192.5 million ETB through targeted improvements in human resources and medical supply management.

Elias Asfaw Zegeye, Josue Mbonigaba, Ermias Dessie2026-07-14
📄 medicine

Filamentary Keratitis and Sjogren's Syndrome: Pathogenesis, Clinical Features, and Screening Implications

This paper synthesizes current evidence on the pathogenesis and clinical features of filamentary keratitis associated with Sjogren's syndrome, presenting case examples to argue that ophthalmologists should screen patients with refractory or severe filamentary keratitis for Sjogren's syndrome to facilitate earlier systemic diagnosis and improve outcomes.

Zhu Lin, Cai Hongbing, Chen Weiwen, Zhai Lumei, Ding Chenglu2026-07-14
📄 medicine

Baseline WT1-specific immunity and immune responses to WT1-targeted immunotherapy in pediatric patients with malignant solid tumors at high risk for relapse: results from a biomarker-driven multicenter translational phase II clinical trial

This biomarker-driven phase II trial demonstrates that baseline Wilms tumor gene 1 (WT1)-specific cytotoxic T lymphocyte frequency is a strong predictor of durable clinical outcomes in pediatric patients with high-risk solid tumors receiving WT1-targeted immunotherapy, while also identifying specific immune signatures as candidate biomarkers for early response prediction.

Yoshiko Hashii, Yosuke Hosoya, Yoshihiro Oka, Yusuke Oji, Hiroko Nakajima, Jun Nakata, Fumihiro Fujiki, Soyoko Morimoto (…)2026-07-14
📄 medicine

Who gets screened? Prevalence and determinants of cervical cancer screening among women aged 15–49 in Malawi and Zambia: a cross- sectional analysis of the 2024 Demographic and Health Surveys

This study analyzes 2024 Demographic and Health Survey data to reveal that cervical cancer screening prevalence remains low (under one-third) among women aged 15–49 in Malawi and Zambia, with uptake significantly influenced by age, socioeconomic status, HIV status, and access to health services, highlighting the urgent need for targeted interventions to address these disparities.

Daniel Muli Mutuku, Norah Awuor Okombo, Lilian Ngina, Caleb Nyakundi, Dorcas Nzilani Kanini, Collins Munene Muriungi, Na (…)2026-07-14