📄 medicine

Multidimensional physiological reserve and long-term cardiovascular risk among breast cancer survivors: a prospective UK Biobank study

This prospective UK Biobank study demonstrates that a multidimensional Physiological Reserve Index, derived from simple measures of lung function, grip strength, and waist circumference, effectively identifies long-term cardiovascular vulnerability and significantly improves risk stratification for heart failure, atrial fibrillation, and mortality among breast cancer survivors beyond conventional clinical factors.

Minyi Xing, MInghui Yang, Bingjie Li, Xiaojie Wang, Yiheng Yang, Siting Feng, Dongyang Xu, Yingxin Bi, Jinbo Fan, Jiaqi (…)2026-10-19
📄 medicine

Catatonia in Autism Spectrum Disorder from Preschool to Adolescence: A Retrospective Analysis of Clinical Profiles and Management Outcomes

This retrospective study of 40 children with autism spectrum disorder reveals that catatonia occurs across the pediatric age range, including preschoolers, with age-specific symptom patterns and psychosocial triggers, and suggests that an integrated management approach combining short-term lorazepam with long-term psycho-ecological therapy yields significant clinical improvement.

Yongmei Li, Yipei Xing, Xinghua Liu, Huilin Zhu, Hongzhu Deng, Xiaobing Zou2026-10-19
📄 medicine

Adoption and Implementation of Framework Contracting for Essential Medicines in Ghana: Qualitative Insights from Stakeholders

This qualitative study reveals that while Ghana's framework contracting for essential medicines has improved price consistency and supplier accountability, its failure to ensure uninterrupted availability stems from design flaws that misallocate financial and volume risks, necessitating comprehensive system-wide reforms beyond mere implementation adjustments.

Sarah Ama Kafui Okine, Brian Adu Asare, Desmond Dzidzornu Otoo, Saviour Kwame Yevutsey, Maxwell Ayindenaba Dalaba, Matil (…)2026-10-19
📄 medicine

Umbilical Cord Hernia is Not an Isolated Pathology: High Rate of Associated Anomalies in a Tertiary Center Cohort

This retrospective study of a tertiary center cohort reveals that umbilical cord hernia is frequently associated with major cardiac, chromosomal, and multisystemic anomalies in over half of cases, challenging its traditional classification as an isolated defect and necessitating comprehensive screening protocols similar to those for omphalocele.

MUGE YILDIZ, YAVUZ YILMAZ, ELIF EMEL ERTEN, MUJDEM NUR AZILI, EMRAH SENEL2026-10-19
📄 medicine

Correlation between Serum MMP-1/TIMP-1 Ratio and the Severity of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

This cross-sectional study of 64 Chinese patients with type 2 diabetes reveals that serum MMP-1 levels and the MMP-1/TIMP-1 ratio significantly increase with the severity of diabetic retinopathy, suggesting their potential as novel serological biomarkers for assessing disease progression.

Yanhao Ma, Jing Xiao, Yao Yao, Lijing Cui, Jian Guo, Ruixuan Jia, Xiaotong Ren2026-10-19