medicine papers | Gist.Science

Understanding Contraceptive-Induced Menstrual Changes: Insights from contraceptive discontinuation due to side effects in 7 low- and middle-income countries

This multi-country analysis of seven low- and middle-income nations reveals that contraceptive-induced menstrual changes are a leading cause of method discontinuation, particularly among adolescents and injectable users, highlighting the urgent need to move beyond one-size-fits-all family planning approaches toward personalized contraceptive interventions.

Catherine Akoth, Caleb Nyakundi, Sharonmercy Okemwa, Dorcas Nzilani Kanini, Lilian Ngina, Nancy Muthoni Nyaga, Irene mul (…)2026-07-13

📄 medicine

Parthenolide enhances imatinib activity in gastrointestinal stromal tumor models through stress-associated apoptosis

This study demonstrates that parthenolide enhances the antitumor efficacy of imatinib in gastrointestinal stromal tumor models by inducing stress-associated apoptosis through mechanisms involving ROS elevation, mitochondrial dysfunction, and ER-stress pathway activation.

Longyi Piao, Zheng-Gen Piao, Chun-Hua Zheng, Dongyuan Xu, Xi-Hui Li, Pengcheng Wei, Cho Park, Chuang-Ming Zheng, Toufeng (…)2026-07-13

📄 medicine

A multimodal framework to assess differences in dynamic visual acuity between athletes with and without recent sport-related concussion

This study demonstrates that a multimodal dynamic visual acuity assessment performed during standing and walking can effectively differentiate athletes with a history of recent sport-related concussion from asymptomatic controls, revealing persistent visual-cognitive deficits despite clinical recovery.

Katelyn M. Mitchell, Kristine Dalton, Michael E. Cinelli2026-07-13

📄 medicine

Assessing Patient Safety Culture: A Pioneering Exploratory Study in a Mozambican Tertiary Hospital

This pioneering study in a Mozambican tertiary hospital reveals that while frontline teamwork is a strength, the patient safety culture is significantly compromised by systemic barriers including production pressure, a punitive environment, and inadequate feedback loops, necessitating targeted leadership and communication interventions.

Grácio Fenias Guambe, Elena Bohomol, Mohsin Sidat2026-07-13

📄 medicine

Immediate changes in cervical cancer early-detection knowledge and screening readiness after an experiential learning-based health promotion session in Indonesian Islamic study communities: a one-group pretest-posttest pilot study

This one-group pretest-posttest pilot study in Indonesian Islamic study communities demonstrates that an experiential learning-based health promotion session significantly improved adult women's immediate knowledge, attitudes, and readiness regarding cervical cancer early detection, though the findings remain preliminary pending further controlled longitudinal research to verify actual screening uptake.

Ayu Ulfah Nur Lubis, Asrial Asrial, Solha Efrida2026-07-13

📄 medicine

Proof of Concept of Surface Anticoagulation in Electrically Active Mechanical Mitral Valve Using Biomimetic Glycocalyx: In Vivo Swine Model Study

This study demonstrates that an electrically activated mechanical mitral valve, which mimics the negative charge of the endothelial glycocalyx, successfully prevented valve thrombosis and eliminated the need for long-term systemic anticoagulation in a swine model.

Lokeswara Rao Sajja, Thomas Mathew, Aditya Koppula2026-07-13

📄 medicine

SLC16A13 functions as a novel oncogenic driver in glioma by impairing monocarboxylate transport and mitochondrial redox homeostasis

This study identifies SLC16A13 as a novel oncogenic driver and independent prognostic biomarker in glioma that promotes malignant progression by impairing monocarboxylate transport and disrupting mitochondrial redox homeostasis, thereby highlighting its potential as a therapeutic target.

Shiqiang Yang, Yanwei Liu, Xuhui Hui, Anqiang Yang2026-07-13

📄 medicine

Isolated HBc IgM false reactivity in the absence of acute Hepatitis B: a case report

This case report describes a 28-year-old male with multiple sclerosis whose initial isolated HBc IgM positivity was determined to be a false-positive result caused by heterophile antibodies, as confirmed by undetectable viremia and negative results upon retesting with a heterophilic blocking tube.

Giuseppe Di Pietra, Michele Borghi, Maira Zoppelletto, Mariela Marinova2026-07-13

📄 medicine

Formal Correction of Pivotal Trial Publications Following FDA Safety Drug Withdrawals: A Systematic Case Series (1990 to 2024)

This systematic case series of 29 FDA-withdrawn drugs from 1990 to 2024 reveals that formal, machine-discoverable corrections to pivotal trial publications are exceptionally rare (occurring in only 1.6% of cases) because safety withdrawals typically stem from harms outside the scope of the original trials rather than from flaws in the published efficacy claims themselves.

Phani Kurada2026-07-13

📄 medicine

Polyexposure, Polysocial, and Polygenic Scores for Common, Complex Disease Classification and the Creation of a Clinical Exposure Assessment

This study demonstrates that integrating standardized polyexposure and polysocial scores with polygenic scores significantly improves the classification of common, complex diseases compared to genetic or demographic factors alone, while identifying largely distinct high-risk populations and providing a framework for a pragmatic clinical exposure assessment tool.

Alison Motsinger-Reif, Dillon Lloyd, Farida Akhtari, John House, Chirag Patel, Charles Schmitt, David Fargo, Lawrence Ki (…)2026-07-13

← Previous Next →