📄 medicine

Socioeconomic status and high impact chronic pain among adults in the United States: analysis of the 2016 National Health Interview Survey

This cross-sectional analysis of the 2016 National Health Interview Survey reveals that lower socioeconomic status is independently associated with significantly higher odds of high-impact chronic pain among U.S. adults, highlighting the need for interventions that address educational, employment, and poverty-related inequalities alongside clinical management.

Korin Neh Nforbi, Isaac Obeng Gyasi, Bibiana Frans-Asmah, Philip Obiri Ankomah, Susan Onumanyiwa Nyanteh, Abigail Obeng (…)2026-10-20
📄 medicine

Ameliorative Effect of PRF and Silver Hydroxyapatite Nanoparticles bio-composite on femoral head AVN in a Rat Model

This study demonstrates that a local bio-composite of silver hydroxyapatite nanoparticles and platelet-rich fibrin significantly promotes osteogenesis, angiogenesis, and structural repair in a rat model of early-stage femoral head avascular necrosis, effectively preventing joint collapse and degeneration compared to control treatments.

Aml Awad, Awad Rizk, Mohamed ElAlfy, Mohamed Hamed, Amr M. Abdelghany, Hussain Noorwali, Esam Mosbah, Adel Zaghloul, Gam (…)2026-10-20
📄 medicine

Spatiotemporal Clustering of Tuberculosis Incidence and Identification of Hotspots in Bobonaro Municipality, Timor-Leste: A Five-Year Ecological Study (2021–2025)

This five-year ecological study of Bobonaro Municipality, Timor-Leste, reveals that while tuberculosis incidence exhibited significant spatial clustering in 2023 and 2024, the lack of consistent global autocorrelation across all years highlights the temporal heterogeneity of disease patterns and underscores the value of local spatial analysis for identifying priority areas for targeted surveillance.

Zito Viegas Cruz, Filipe Neri Machado, José Araujo Amaral2026-10-20✓ Author reviewed ⓘ
📄 medicine

Beyond AUROC: External Validation, Calibration, and Explainability of Machine Learning Models for 30-Day Hospital Readmission Using Electronic Health Records—A Rapid Systematic Review

This rapid systematic review of 156 studies reveals that machine learning models predicting 30-day hospital readmission overwhelmingly rely on AUROC as the sole performance metric while critically neglecting essential evaluations of external validity, calibration, and explainability, prompting a call for a more rigorous "beyond AUROC" assessment framework.

Md Eftakhar Ahamed, Md. Istiakul Alam, Mohammad Shamsul Arefin2026-10-20
📄 medicine

Can Daily Drills of Ventilation Corrective Steps Improve Mask Ventilation of Preterm Infants in the Delivery Room? – A Randomized Controlled Trial

This randomized controlled trial demonstrates that brief, daily simulation drills of MR SOPA ventilation corrective steps significantly reduce mask leak during positive pressure ventilation in delivery room resuscitations of preterm infants compared to self-directed review of the NRP algorithm.

Emediong E. Idung, Megan O’Reilly, Po-Yin Cheung, Georg M. Schmölzer2026-10-20
📄 medicine

Cost-Effectiveness Analysis of Ivonescimab Plus Chemotherapy versus Tislelizumab Plus Chemotherapy as First-Line Treatment for Advanced Squamous Non-Small Cell Lung Cancer: A Chinese Healthcare Perspective

From a Chinese healthcare perspective, a cost-effectiveness analysis based on the HARMONi-6 trial indicates that first-line treatment with ivonescimab plus chemotherapy is likely to be cost-effective compared to tislelizumab plus chemotherapy for advanced squamous non-small cell lung cancer, with an incremental cost-effectiveness ratio of $23,366.05 per quality-adjusted life-year gained.

Chuang Yang, Shixian Liu, Tiantian Xuan, Wen Zhao, Jisheng Li2026-10-20
📄 medicine

Molecular Mechanisms and Clinical Impact of HighLevel Ceftazidime Avibactam Resistance in CarbapenemResistant Pseudomonas aeruginosa

This study elucidates that high-level ceftazidime-avibactam resistance in carbapenem-resistant *Pseudomonas aeruginosa* is primarily driven by metallo-β-lactamase production (specifically AFM-1 and IMP-45), novel GES variants, and synergistic efflux pump overexpression, contributing to a high mortality rate of 68.1% among critically ill patients.

Jiao Chen, Chenyan Gao, Fen Wan, Xinhui Liao, Wenjie Liu, Xinyi Tian, Heng Zhao, Dandan Wei, Yang Liu, Guanghui Li2026-10-19