📄 medicine

Development and Preliminary Application of an Entrustable Professional Activities-Based Evaluation Indicator System for Rehabilitation Nursing among Undergraduate Nursing Interns

This study successfully developed and preliminarily validated a seven-domain, 46-item Entrustable Professional Activities (EPA) evaluation indicator system for undergraduate nursing interns in rehabilitation, demonstrating strong expert consensus and clinical feasibility to inform future rehabilitation nursing education.

Junying Qian, Ruixin Wang, Xin Zhang, Xiaoqing Si, Yiying Zhu, Yun Li, Yue Sun, Dongxu Liu, Yan Wang2026-10-19
📄 medicine

Feasibility, acceptability and adaptation of S-Condom Uterine Balloon Tamponade (UBT) in managing atraumatic post-partum hemorrhage at a tertiary care facility in Bangladesh

This prospective mixed-methods study demonstrates that the low-cost, prepackaged S-Condom Uterine Balloon Tamponade is a highly feasible, safe, and acceptable intervention for managing refractory atraumatic postpartum hemorrhage in Bangladesh, achieving a 100% success rate and high provider and patient satisfaction.

Tanjila Karim, Sayeba Akhter, Saria Tasnim, Shahena Akter, Shahanara Chowdhury, Md. Zulqarnine Ibne Noman, Quamrun Nahar2026-10-19
📄 medicine

Enzymatic Debridement as a Tissue-Sparing Wound Bed Preparation Strategy in a Preterm Newborn With Postoperative Wound Dehiscence: An Off-Label Case Report

This case report demonstrates that off-label bromelain-based enzymatic debridement is a safe and effective tissue-sparing strategy for managing complex postoperative wound dehiscence in a preterm newborn, leading to rapid wound closure without adverse events.

Biagio Nicolosi, Greta Ghizzardi, Benedetta Virginia Difalco, Bettina Violini, Enrico Ciardini, Marco Moroni, Alessandra (…)2026-10-19
📄 medicine

Endocrine toxicity associated with anti - neoplastic drugs: a pharmacovigilance analysis based on the FDA adverse event reporting system database

This pharmacovigilance study analyzing over 40,000 FAERS reports identifies robust safety signals linking anti-neoplastic drugs, particularly immune checkpoint inhibitors like pembrolizumab and ipilimumab, to endocrine toxicity, highlighting a higher prevalence in females and a tendency for early onset to underscore the need for enhanced clinical monitoring.

Xingnong Xu, Cheng Fan, Xiaofeng Cheng2026-10-19
📄 medicine

Supply and Demand Constraints Generating Health Policy and Systems Research in Cambodia: A Qualitative Institutional Analysis

This qualitative institutional analysis of Health Policy and Systems Research (HPSR) in Cambodia identifies critical supply and demand constraints, including limited local capacity, low domestic demand for evidence, and donor dominance, which collectively hinder the generation of contextually relevant, evidence-informed health policies and underscore the urgent need for strengthened local ownership and resource allocation to ensure sustainable system learning.

Laura Trakman, Savina Chham, Hay Vannith, Chhorvann Chhea, Ziru Deng, Karen Grépin2026-10-19
📄 medicine

Integrative transcriptomic and machine learning analyses identify ABCD1 as a diagnostic and prognostic biomarker in cutaneous melanoma

By integrating bulk and single-cell transcriptomic data with machine learning algorithms, this study identifies ABCD1 as a robust diagnostic and prognostic biomarker that is highly expressed in malignant melanoma cells and correlates with poor patient survival and advanced disease stages.

Hongyang Zhang, Yang Rui, Huan Liu, Le Wang, Jing Yang, Jinping Li, Nan Yu2026-10-19
📄 medicine

Willing but unable? Knowledge producers and users’ knowledge, attitudes and practices (KAP) in translating research evidence into health policy and practice in Guinea, 2025

This 2025 mixed-methods study in Guinea reveals a paradox where health stakeholders hold positive attitudes toward evidence-informed decision-making yet face significant structural barriers, such as poor communication channels and misaligned incentives, which severely limit the actual translation of research into health policy and practice.

Tamba Mina Millimouno, Antea Paviotti, Patrice Ngangue, Makany Sangaré, Alain Kourouma, Tamba Leno, Mamadou Macky Sy, Al (…)2026-10-19
📄 medicine

Interpretable Concept-Bottleneck Vision-Language Model Predicts Pathologic Complete Response From Longitudinal Breast DCE-MRI

This study presents an interpretable concept-bottleneck vision-language model that predicts pathologic complete response in breast cancer patients using longitudinal DCE-MRI data by routing predictions through radiologist-recognizable imaging concepts, thereby achieving generalizable performance while transforming a black-box task into a transparent and auditable clinical tool.

Charlotte N. Li, Daksh Khurana, Takouhie Maldjian, Tim Duong2026-10-19