13699 papers
This case report describes a patient with chronic drug-induced liver injury exhibiting autoimmune-like features who achieved biochemical remission and histological improvement over time, highlighting the importance of long-term follow-up and repeat liver biopsies to assess persistent histological damage even after biochemical normalization.
Although the prevalence of pit and fissure sealants among 12-year-old children in Puerto Rico significantly increased between 1997 and 2011 following the implementation of Government Health Insurance, a persistent socioeconomic disparity remained, with children in public schools having lower sealant rates than those in private schools.
This study suggests that while exercise-induced systolic pulmonary arterial pressure does not significantly differ between hereditary hemorrhagic telangiectasia patients with high versus normal cardiac output, the steeper systolic pressure-to-cardiac output slope in high-output patients may serve as an early marker for cardiovascular impairment and future pulmonary hypertension risk.
This study demonstrates that a locked two-pathway transcriptomic score for early mortality in diffuse large B-cell lymphoma retains a reproducible association across independent cohorts primarily through an immune-depletion signal, though it currently lacks the calibration required for clinical predictor or treatment threshold use.
In a seven-year study of older Chinese adults, frailty alone or combined with sarcopenia significantly increased the risk of falls and hip fractures compared to neither condition, whereas sarcopenia alone showed no clear association and the coexistence of both conditions did not confer excess risk beyond their individual effects.
Despite good knowledge and favorable attitudes, adverse drug reaction reporting among healthcare professionals in private health facilities in Mbarara City, Uganda, remains critically low (12.9%) due to systemic barriers such as the unavailability of reporting tools, lack of feedback, and insufficient training, highlighting an urgent need to strengthen pharmacovigilance infrastructure in the private sector.
This retrospective study of 32 elderly patients demonstrates that postoperative serous wound discharge following hip arthroplasty for proximal femur fractures is driven by hypoalbuminemia rather than infection, as evidenced by universally sterile cultures, the resolution of discharge with albumin supplementation, and the lack of benefit from broader antibiotic therapy for concurrent non-wound infections.
This prospective Level I study demonstrates that a hybrid fixation strategy combining open reduction and internal fixation with a temporary external fixator yields excellent functional outcomes and high anatomical reduction rates while effectively preventing hardware failure in patients with locked symphysis pubis.
This multi-database landmark study identifies three distinct 24-hour early resuscitation-response phenotypes in critically ill adults with acute pancreatitis, revealing that a high-intensity phenotype characterized by concurrent fluid, vasopressor, and lactate burden is associated with subsequent organ-support escalation and delayed alive ICU discharge.
This scoping review argues that surgical conscience should be redefined as a teachable, observable interprofessional competency rather than an assumed virtue, proposing the VOICE-OR framework to guide curricula that progress from risk recognition to workplace safety outcomes by addressing barriers like hierarchy and fostering psychological safety.