13699 papers
This descriptive mixed-methods study demonstrates that Nepal's first hybrid multidisciplinary trauma simulation training significantly boosted participant confidence and satisfaction while highlighting its feasibility and impact for strengthening trauma care capacity in low-resource settings.
This single-center retrospective study of 1,373 CIN3 patients undergoing LEEP demonstrates that while a nomogram incorporating TCT grade, age, BMI, multiple HPV infection, and parity effectively predicts positive surgical margins (AUC 0.80), systemic inflammatory markers such as SIRI and NLR do not serve as independent predictors.
This study demonstrates that elevated IKBIP expression in glioma correlates with higher tumor grade, specific immune cell infiltration (CD8+ and CD56+), and poor patient prognosis, establishing it as a potential independent biomarker and therapeutic target.
This retrospective study of 86 patients undergoing Hartmann's reversal demonstrates that routine postoperative inflammatory biomarkers, particularly the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) measured on day 3, show clinically relevant discrimination for detecting anastomotic leakage, although no single marker proved statistically superior to the others.
In a retrospective cohort study of 1,602 adults undergoing intracranial neurosurgery, greater intraoperative time-weighted average excess oxygen exposure was significantly associated with an increased likelihood of mechanical ventilation being recorded 24–48 hours postoperatively, though the findings do not establish causality or define a specific clinical oxygen target.
This study retrospectively analyzed 1,320 children to demonstrate that a combined diagnostic model utilizing white blood cell counts, C-reactive protein levels, and clinical features effectively distinguishes genuine *Mycoplasma pneumoniae* infections from asymptomatic carriers, addressing the limitations of conventional PCR and serological tests.
This prospective cohort study of 442 elderly arthroplasty patients demonstrates that higher preoperative dietary fiber intake significantly reduces the risk of perioperative neurocognitive disorders, with short-chain fatty acids acting as a complete mediator in this protective gut-brain axis mechanism.
This retrospective cohort study demonstrates that an XGBoost-based machine learning model, utilizing only arterial blood gas parameters and minimal clinical features, achieves robust early prediction of retinopathy of prematurity with high sensitivity and accuracy across multiple Chinese medical institutions.
This study utilizes a disproportionality analysis of FAERS and cross-database validation in JADER to identify seven confirmed immune-related adverse events associated with pembrolizumab and nivolumab in colorectal cancer patients, demonstrating that disease-matched comparators are essential to distinguish true drug toxicity from background disease symptoms.
This case report describes an 11-year-old girl with a rare giant ileocecal inflammatory myofibroblastic tumor causing severe paraneoplastic inflammatory syndrome, which was successfully treated with complete surgical resection, leading to the rapid resolution of systemic inflammatory and hematologic abnormalities.