📄 medicine

Effect of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio on early neurological deterioration in patients with large artery atherosclerotic ischemic stroke

This retrospective study of 432 patients with large artery atherosclerotic ischemic stroke demonstrates that an elevated admission non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is an independent predictor of early neurological deterioration, suggesting its utility as a simple biomarker for early risk stratification.

Jinglong Sun, Yaqiang li2026-07-12
📄 medicine

Proportion and Associated Factors of Maternal Near Miss among Northwest Ethiopian women following Armed conflict: A Cross sectional study

This 2025 cross-sectional study at the University of Gondar Comprehensive Specialized Hospital in Northwest Ethiopia found that maternal near miss occurs in 14.3% of admitted women following armed conflict, with significant associations identified for primiparity, lack of antenatal care, and delays in seeking or receiving care.

Leul Endalamaw Demilew, Yemisrach Alemneh Ayanaw, Esmael Ali Mohammed, Bezawit Alemu Mengist, Misganaw Abere Worku, Asna (…)2026-07-12
📄 medicine

Bridging the Representation Gap in the Surgical Workforce: A Scoping Review of Programs and Interventions to Support Surgical Careers for Underrepresented Minority Learners

This scoping review maps diverse interventions supporting underrepresented minority learners in surgery, finding that while such programs are increasingly common and improve short-term metrics like interest and confidence, their impact is limited by inconsistent definitions and methodologies, highlighting the need for standardized, longitudinal, and institutionally embedded strategies to achieve durable representation gains.

Meerab Majeed, Aljeena Rahat Qureshi, Vidhi Bhatt, Ajibola Anifowose, Negeen Halabian, Armaghan Alam, David-Dan Nguyen (…)2026-07-12
📄 medicine

CHA₂DS₂-VASc Score for Pre-Procedural Prediction of Contrast-Associated Acute Kidney Injury After Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction: A Head-to-Head Comparison with the Mehran Score

In a prospective cohort of STEMI patients undergoing primary PCI, the pre-procedural CHA₂DS₂-VASc score demonstrated comparable predictive accuracy for contrast-associated acute kidney injury to the post-procedural Mehran score, offering a practical, bedside alternative for risk stratification in resource-limited settings where laboratory data is unavailable prior to the procedure.

Sushant Kharel, Birat Krishna Timalsena, Amrit Bogati, Mohammed Sajjad Safi, Pratik Thapa, Rahul Yadav, Vijay Ghimire, C (…)2026-07-12
📄 medicine

Patient and Physician Preferences for Treatment in Advanced Renal Cell Carcinoma in Asia-Pacific (PEAR)- A Discrete Choice Experiment

This discrete choice experiment involving patients and physicians in the Asia-Pacific region reveals that while both groups prioritize overall survival, complete response, and duration of response, patients are significantly more risk-averse regarding treatment side effects like pneumonitis compared to physicians, underscoring the need for shared decision-making that integrates these divergent benefit-risk trade-offs.

Alison Zhang, Niara Oliveira, Bryan Li, Inkeun Park, Miso Kim, Sharon Yu Lin Chua, Anilda Anthony D’Souza, Sameer Gokhal (…)2026-07-12
📄 medicine

Mechanisms of Attainment Gaps in UK Surgical Training: A National Qualitative Study of Trainee Experiences

This national qualitative study reveals that attainment gaps in UK surgical training stem from the interaction between organizational barriers and unequal access to social, financial, and cultural capital, which disproportionately affects female, ethnically minoritized, and gateway pathway trainees, thereby necessitating structural reforms alongside targeted support to ensure equitable progression.

Nicholas Uren, Gayatri Tadikamalla, Ahmad Elmansouri, Benjamin Preston, Judith Cave, Sally Curtis2026-07-12
📄 medicine

Patient-Reported Outcomes and Sexual Function After Nerve-Sparing Pelvic and Para-Aortic Lymphadenectomy With or Without Suprarenal Extension in Presumed Early-Stage Endometrial Cancer

In patients with presumed early-stage endometrial cancer, nerve-sparing pelvic and infrarenal lymphadenectomy does not significantly impair long-term quality of life or sexual function, whereas suprarenal extension is associated with worse outcomes, and extensive lymphovascular space invasion serves as a strong predictor of nodal metastasis.

Valentina Auletta, Lydia Kirstan, Angela Kather, Davit Bokhua, Tobias Franiel, Ingo Bernarnd Runnebaum2026-07-12
📄 medicine

Association between the blood urea nitrogen to albumin ratio and all-cause mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a multicenter retrospective study and machine learning with external validation

This multicenter retrospective study with external validation and machine learning analysis demonstrates that a higher blood urea nitrogen to albumin ratio (BAR) is an independent predictor of increased all-cause mortality at 30, 90, and 365 days in critically ill patients with non-traumatic subarachnoid hemorrhage.

Liang Liu, Zhilei Huang, Binbin Gui, Lin Xu, Wei Zhang, Yansong Liu, Haowei Luo, Xiangtong Zhang2026-07-12
📄 medicine

Joint Associations of Serum Vitamin D and Physical Activity with Bone Mineral Density and Body Composition in U.S. Adolescents: A Cross-Sectional Study Based on NHANES 2011-2018

This cross-sectional study of U.S. adolescents using NHANES 2011–2018 data reveals that higher serum vitamin D levels are positively associated with better bone mineral density and lean mass while negatively linked to visceral fat, with these beneficial effects being significantly stronger among physically active individuals.

Bingrong Tang¹, Chunxiang Yan¹, Han Xia¹, Min Wang¹, Ji Wu², Xiaobing Feng¹2026-07-12