medicine papers | Gist.Science

Functional epigenomic liquid biopsy identifies potential therapeutic vulnerabilities after enfortumab vedotin–pembrolizumab resistance in metastatic urothelial carcinoma (mUC)

This study demonstrates that longitudinal functional epigenomic liquid biopsy using H3K4me2 cfChIP-seq can identify dynamic regulatory reprogramming and emerging therapeutic vulnerabilities, such as ERBB2 activation, in metastatic urothelial carcinoma patients developing resistance to enfortumab vedotin–pembrolizumab, thereby offering a strategy to guide subsequent biomarker-driven treatment.

Joaquim Bellmunt, Rong Li, Sara El Sarout, Yingtian Xie, Gunsagar Gulati, Ilana Epstein, Shweta Kukreja, Luisa Rodriguez (…)2026-10-19

📄 medicine

Measuring health facility readiness for obstetric fistula surgery and care in Busoga sub-region, eastern Uganda: Development of scoring criteria/framework for facility readiness and application to six hospitals in the region

This study developed and applied a consensus-based seven-domain scoring framework to assess six hospitals in eastern Uganda, revealing that only one facility met the readiness threshold for routine obstetric fistula surgery due primarily to critical deficits in specialized human resources, equipment, and clinical protocols.

Peter Kivunike Mukasa, Mary Kinney, Steven Katende, Wilberforce Mugwanya, Abdmagidu Menya, Smule Kizza Sajjabi, Alison E (…)2026-10-19

📄 medicine

A Case of Misidentity: Rare Case of Hidradenocarcinoma of Ear

This paper reports a rare case of hidradenocarcinoma of the ear in a 75-year-old male, emphasizing the diagnostic challenge of distinguishing this aggressive malignancy from benign lesions and highlighting the importance of histopathological confirmation and long-term surveillance following surgical excision.

Dhanish Gopalakrishnan, Farah Dayana Zahedi2026-10-19

📄 medicine

Extrapulmonary Tuberculosis Presenting as an Infected Preauricular Sinus

This paper reports a rare case of an 18-year-old Malay male diagnosed with extrapulmonary tuberculosis manifesting as an infected preauricular sinus, which was successfully treated with anti-tuberculosis medication followed by surgical excision.

Dhanish Gopalakrishnan, Wan Nabila Wan Mansor2026-10-19

📄 medicine

The NT-proBNP/hs-cTnT Ratio Identifies Distinct Hemodynamic Phenotypes in Wild-type Transthyretin Cardiac Amyloidosis: a multicenter Italian study

This multicenter Italian study demonstrates that the NT-proBNP/hs-cTnT ratio stratifies patients with wild-type transthyretin cardiac amyloidosis into three distinct hemodynamic phenotypes characterized by progressively worsening cardiac function, renal impairment, and atrial fibrillation prevalence.

Federica Bellini, Daniela Di Lisi, Emilio Nardi, Carola Maria Gagliardo, Gabriele Di Gesaro, Antonina Giammanco, Lucio T (…)2026-10-19

📄 medicine

Simulation-Based Ultrasound Training and Clinical Performance in Obstetric Residents: A Prospective Controlled Exploratory Pilot Study

This prospective controlled pilot study suggests that six weeks of structured simulation-based training improves clinical ultrasound performance and technical skills in obstetric residents compared to routine training, although the results did not reach statistical significance due to the small sample size.

Livia Schuler, Sara Ardabili, Markus Hodel, Benedict Krischer2026-10-19

📄 medicine

Adenosquamous carcinoma of the colon with an aberrant MLH1 immunostaining pattern: a diagnostic pitfall in mismatch repair assessment

This paper reports a rare case of adenosquamous carcinoma of the colon with a mismatch repair deficiency profile complicated by a granular MLH1 staining artifact, highlighting the critical need to recognize such patterns to avoid misdiagnosis and ensure accurate therapeutic decision-making.

Beatriz Gioppo Betini, Wilker Dias Martins2026-10-19

📄 medicine

Baseline dentition and incident dementia in Chinese very‑old adults: denture use, functional limitation, CLHLS 2008‑2018

In a large cohort of Chinese very-old adults, baseline natural tooth count was not independently associated with incident dementia, whereas denture use and activities of daily living limitations emerged as significant prognostic factors for dementia risk.

Nan Yu, Yidan Zeng, Xilin Ge, Danqi Yang2026-10-19

📄 medicine

Employment-type inequalities in healthy working life expectancy in China: evidence from CHARLS, 2011–2018

Using data from the China Health and Retirement Longitudinal Study (2011–2018), this study reveals that employment-type inequalities significantly shape healthy working life expectancy among older Chinese adults, with agricultural workers facing the highest burden of unhealthy work, particularly women, suggesting that retirement reforms must account for these disparities rather than relying solely on average longevity.

Yulong Li¹, Panpan Wang¹, Qianyu Zhou², Mingyang Zhao², Ruoyao Huang³, Jiajun Chen, Hexin Zhang¹, Yang Yang¹, Yuxin Chen (…)2026-10-19

📄 medicine

Cost-utility analysis on the inclusion of pneumococcal vaccines in the national immunization program for older adults in the Philippines – Evidence from a middle-income country in Asia

This cost-utility analysis of pneumococcal vaccination strategies for older adults in the Philippines concludes that while sequential PCV13/PPV23 and PCV15/PPV23 regimens offer additional health benefits, PPV23 alone is the most cost-effective and budget-saving option, yielding the lowest incremental cost-effectiveness ratio and net cost savings compared to no vaccination.

Haidee Valverde, Josephine Aldaba, Ruth Anne Hechanova-Cruz, Joseph Carlo Cruz, Merrylle Morales-Dizon, Napoleon III Ber (…)2026-10-19

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