📄 medicine

Effect of Left Ventricular Assist Device Pulsatility Mode and Cannula Angle on Aortic Blood Flow Characteristics, Blood Renewal Efficiency, Hemolysis, and Platelet Activation

This computational study demonstrates that optimizing left ventricular assist device (LVAD) outcomes requires balancing the competing effects of outflow graft angle, pulsatile support, and native cardiac recovery on aortic hemodynamics, blood washout, and hemocompatibility.

Kangli Sun, Yue Han, Gaoyang Li, Zengsheng Chen2026-10-19
📄 medicine

A 4D Ultrasound Strain Imaging Framework for In Vivo Identification of Anisotropic Properties in Abdominal Aortic Aneurysms: Preliminary Validation against Mechanical Testing of Porcine and Human Tissue

This paper presents and preliminarily validates a computationally efficient, non-invasive 4D ultrasound framework that identifies patient-specific anisotropic mechanical properties of abdominal aortic aneurysm walls by solving an inverse finite element problem, demonstrating strong agreement with mechanical testing in both porcine and human tissues.

Achim Hegner, Andreas Wittek, Wojciech Derwich, Manuel Schönborn, Kyriakos Oikonomou, Armin Huß, Antonio J. Gámez, Chris (…)2026-10-19
📄 medicine

Initial Cisternal Access for Cerebrospinal Fluid Release During Retrosigmoid Resection of Large Vestibular Schwannomas: A Surgeon-Stratified Comparative Cohort Study

In a surgeon-stratified retrospective cohort study of 100 patients undergoing retrosigmoid resection of large vestibular schwannomas, initial cerebrospinal fluid release via the lateral cerebellomedullary cistern was associated with significantly shorter operative times, fewer postoperative cerebellar diffusion-weighted imaging abnormalities, and reduced dizziness compared to cisterna magna access, though the non-protocolized selection limits causal conclusions.

Zhiwei Shen, TingTing Fan, Yanhong Pan, Shenglong Cao, Junwen Hu, Yulong Lan, Xiangdong Zhu, Jingsen Chen, Lin Wang, Gao (…)2026-10-19
📄 medicine

Early PD-1 and CTLA-4 Expression on Peripheral Blood T Cells and Subsequent Chronic Critical Illness and 28-Day Mortality: A Prospective Cohort Study

This prospective cohort study demonstrates that early upregulation of PD-1 and CTLA-4 expression on peripheral T cells, particularly the proportion of CD4+ PD-1+ T cells, is strongly associated with the development of chronic critical illness and 28-day mortality in critically ill adults, suggesting these immune checkpoints serve as promising biomarkers for early risk stratification.

Tianwen Huang, Jinze Li, tianlan Huang, Pengqiang Yang, Jifan Zhu, jinjuan zhao, zhicong Lin, Qinghong Cheng2026-10-19
📄 medicine

Physiology-augmented deep representations improve cross-database electrocardiogram beat classification under unseen-domain shift

This study demonstrates that augmenting deep neural network embeddings with physiological descriptors significantly improves cross-database electrocardiogram beat classification performance under unseen domain shifts, offering a robust solution for generalizing models across different institutions and devices without target-domain adaptation.

Mujahid Shahid, Oliver Konyo2026-10-19
📄 medicine

The role of community pharmacists in updating the vaccination schedule: a descriptive analysis of vaccination data in the greater Paris Region, 2022-2024

This descriptive analysis of 2022–2024 vaccination data in the greater Paris Region demonstrates that community pharmacists significantly expanded their role in administering and prescribing vaccines, particularly for influenza and newly recommended immunizations like HPV and pertussis, thereby highlighting their critical responsiveness to updated schedules and epidemic situations.

Samia Charrhine, Rebecca Bauer, Nicolas Chavoutier, Laetitia Fleury, Imène Sahraoui, Laurène Deconinck, Liem Binh Luong (…)2026-10-19
📄 medicine

Multidimensional physiological reserve and long-term cardiovascular risk among breast cancer survivors: a prospective UK Biobank study

This prospective UK Biobank study demonstrates that a multidimensional Physiological Reserve Index, derived from simple measures of lung function, grip strength, and waist circumference, effectively identifies long-term cardiovascular vulnerability and significantly improves risk stratification for heart failure, atrial fibrillation, and mortality among breast cancer survivors beyond conventional clinical factors.

Minyi Xing, MInghui Yang, Bingjie Li, Xiaojie Wang, Yiheng Yang, Siting Feng, Dongyang Xu, Yingxin Bi, Jinbo Fan, Jiaqi (…)2026-10-19
📄 medicine

Catatonia in Autism Spectrum Disorder from Preschool to Adolescence: A Retrospective Analysis of Clinical Profiles and Management Outcomes

This retrospective study of 40 children with autism spectrum disorder reveals that catatonia occurs across the pediatric age range, including preschoolers, with age-specific symptom patterns and psychosocial triggers, and suggests that an integrated management approach combining short-term lorazepam with long-term psycho-ecological therapy yields significant clinical improvement.

Yongmei Li, Yipei Xing, Xinghua Liu, Huilin Zhu, Hongzhu Deng, Xiaobing Zou2026-10-19