3199 papers
This study reports the rational design, synthesis, and evaluation of novel ferulic acid–based hydrazide derivatives as ALK inhibitors for non-small cell lung cancer, identifying FBH4 as the most potent and promising lead candidate with an IC₅₀ of 71.33 µM/ml that rivals crizotinib.
This ambispective study demonstrates that functional outcomes following delayed open reduction and K-wire fixation of neglected paediatric lateral humeral condyle fractures are determined by the structural and physeal integrity of the elbow rather than the duration of injury neglect.
This Tunisian cohort study reveals that laryngeal squamous cell carcinoma cases positive for high-risk HPV exhibit a distinct tumor microenvironment characterized by significantly increased infiltration of CD8⁺ T cells, FOXP3⁺ regulatory T cells, and tumor-associated macrophages compared to HPV-negative cases.
This study presents a proof-of-concept automated deep learning pipeline that demonstrates excellent agreement with manual measurements for assessing aortic remodeling in patients undergoing frozen elephant trunk repair, offering a scalable solution to overcome the labor-intensive limitations of current CT-based analysis.
A quasi-experimental study in a Chinese tertiary hospital demonstrates that a dual-track management model combining empowerment and supervision significantly improved the quality, safety, and reliability of SBAR handoffs among junior ICU nurses while enhancing their self-efficacy and collaboration.
This cross-sectional study of 55 young adults with acute coronary syndrome at AIIMS Rishikesh demonstrates a significant positive association between elevated Lipoprotein(a) levels and increased coronary angiographic severity as measured by the SYNTAX score, suggesting Lp(a) is a valuable marker for risk stratification in premature coronary artery disease.
Solid-state fermentation of amaranth with *Rhizopus oligosporus* significantly enriches its polyphenol content, which alleviates insulin resistance by activating the IRS-1/PPARγ-mediated GLUT4 pathway in both hepatocytes and adipocytes, offering a promising food-grade strategy for managing metabolic disorders.
This two-center study demonstrates that while single- and multi-frequency bioelectrical impedance analyzers exhibit systematic, device-specific biases compared to dual-energy X-ray absorptiometry, applying device-specific calibration equations significantly improves accuracy and low-muscle-mass classification in external validation, underscoring that BIA and DXA cannot be used interchangeably without adjustment.
This study utilizes resting-state fMRI and graph theory analysis of PPMI data to demonstrate that early-stage Parkinson's disease is characterized by specific alterations in functional connectivity and network topology, particularly within the default mode network, which are significantly associated with depressive symptom severity.
This study of Lithuanian adults reveals that the associations between anthropometric indices (ABSI, BRI, and BMI) and carotid plaque prevalence are complex and non-linear, particularly in men, where lower index values did not consistently indicate lower cardiovascular risk and often coincided with higher metabolic abnormalities.