13699 papers
This qualitative study reveals that while Ghana's framework contracting for essential medicines has improved price consistency and supplier accountability, its failure to ensure uninterrupted availability stems from design flaws that misallocate financial and volume risks, necessitating comprehensive system-wide reforms beyond mere implementation adjustments.
This cadaveric study demonstrates that while both xenograft and autogenous graft materials significantly increase primary implant stability in immediate placement procedures, there is no statistically significant difference in their effectiveness.
This retrospective study of a tertiary center cohort reveals that umbilical cord hernia is frequently associated with major cardiac, chromosomal, and multisystemic anomalies in over half of cases, challenging its traditional classification as an isolated defect and necessitating comprehensive screening protocols similar to those for omphalocele.
This study presents a dual-functional kaempferol-doped lipid nanoparticle platform that simultaneously mitigates nebulization-induced pulmonary inflammation and significantly enhances endosomal escape for effective mRNA-based lung cancer therapy.
This cross-sectional study of 64 Chinese patients with type 2 diabetes reveals that serum MMP-1 levels and the MMP-1/TIMP-1 ratio significantly increase with the severity of diabetic retinopathy, suggesting their potential as novel serological biomarkers for assessing disease progression.
This study demonstrates that nebulized fasudil effectively reduces airway smooth muscle contractility and lung resistance in ex vivo sheep lungs by inhibiting myosin light chain phosphorylation, thereby supporting its potential repurposing for the treatment of human asthma.
This 10-year retrospective study of nearly 620,000 emergency department encounters validates that while ICD-coded Acute Coronary Syndrome labels exhibit high sensitivity and specificity, their moderate positive predictive value is driven by systematic, interpretable errors—primarily suspected cases later ruled out or coder omissions—making them suitable training labels for AI screening models where missing a diagnosis is more critical than over-identification.
This cross-sectional study of 253 motorcycle taxi drivers in Cotonou, Benin, reveals a coexisting double burden of underweight and overweight driven by a poorly diversified, carbohydrate-dominant diet, with low dietary diversity linked to underweight and alcohol consumption associated with overweight.
This five-year longitudinal study of 958 Guangzhou residents reveals heterogeneous trends in serum legacy PFAS levels, characterized by decreases in most compounds but a notable increase in PFOA, with exposure patterns significantly influenced by age and residential location.
This protocol outlines a systematic review and meta-analysis designed to synthesize evidence on the prevalence and risk factors of child sexual abuse among children aged 8 years and younger across Africa, aiming to address critical knowledge gaps and inform targeted prevention policies and child protection systems.