816 papers
This study identifies and characterizes three genetically distinct lytic bacteriophages isolated from environmental samples that effectively target multidrug-resistant *Klebsiella pneumoniae* strains causing urinary tract infections, demonstrating enhanced lytic activity in human urine compared to standard laboratory media.
This study reveals that in *Thermococcus barophilus*, the 23S rRNA undergoes a unique circular permutation resulting from the deletion of helix H98, yet this altered form is successfully integrated into functional 50S ribosomal subunits and 70S monosomes.
This study demonstrates that repurposing the clinical GeneXpert II platform for field deployment enables rapid, near-real-time surveillance of avian influenza viruses in New Zealand's wildlife and environmental samples, providing a practical early warning system for high-risk interfaces like Taiaroa Head.
Using Hazara virus as a BSL-2 model for Crimean-Congo Hemorrhagic Fever virus, this study employed ChIRP-MS to map the RNA-protein interactome in *Hyalomma* tick cells, revealing that the viral S segment predominantly binds to mitochondrial proteins involved in metabolic pathways.
Dietary supplementation with 100 mg/kg chitosan mitigates the negative effects of Enterohemorrhagic Escherichia coli O157:H7 challenge in weaned piglets by enhancing intestinal barrier integrity, reducing inflammation, and improving growth performance through the upregulation of tight junction proteins and nutrient transporters.
This study demonstrates that integrating a synthetic microbial consortium of *Shewanella oneidensis*, *Pseudomonas putida*, and *Ophiostoma piceae*, supplemented with the quorum sensing analogue 1-dodecanol, into microbial fuel cell-hydroponic systems significantly enhances bioelectricity generation and produces plant growth-promoting substances, thereby optimizing the dual performance of wastewater treatment and crop nutrition.
This paper presents the development and validation of a novel in situ spectroscopy system for the Cell Spinpod rotating wall vessel that enables real-time, high-resolution monitoring of optical density and fluorescence in liquid microbial cultures under simulated microgravity, overcoming previous limitations that required destructive sampling.
This study utilizes integrated 16S rRNA and shotgun metagenomic analyses to demonstrate that cervicovaginal dysbiosis in HPV-negative women is characterized by a loss of Lactobacillus and a specific enrichment of Achromobacter species, which the authors identify as a potential microbial biomarker for female infertility.
This study demonstrates the engineering of *Pseudomonas putida* KT2440 to simultaneously convert enzymatic hydrolysates of mixed plastic waste (PET, PBAT, PU, and PLA) into valuable (R)-3-hydroxybutyrate, establishing a viable biological route for the open-loop upcycling of diverse plastics.
This study reveals that in *Pseudomonas aeruginosa*, RNase E regulates Type II RhlB helicases by binding to a distinct interface to dissolve their toxic, RNA-driven liquid-liquid phase separation condensates, thereby preventing growth defects at low temperatures and establishing condensate dissolution as a novel regulatory mechanism for RNA helicase activity.
In 2021, an outbreak of *Leptospira interrogans* serovar Canicola affected over 200 unvaccinated dogs in Los Angeles County, with whole genome sequencing confirming distinct strains, urine PCR proving the most sensitive diagnostic tool, and indoor congregate facilities identified as a significant risk factor.
Ultraviolet exposure remodels the skin to create a durable, virus-permissive tissue state that enhances arbovirus replication and mortality while simultaneously increasing mosquito attraction, thereby establishing sunlight as a critical environmental determinant of vector-borne disease susceptibility and transmission.
This study demonstrates that mucins significantly modulate the infection dynamics and biofilm formation of the enteropathogen *Yersinia enterocolitica* by enhancing phage replication and acting as a nutrient source, while also driving the evolution of bacterial resistance through mutations in virulence and regulatory genes, thereby highlighting the critical role of mucosal environments in shaping phage-host interactions for therapeutic applications.
This study defines the translatome of quiescent *Plasmodium falciparum* stage V gametocytes to identify essential molecular pathways for transmission, specifically validating that parasite pyridoxal 5'-phosphate biosynthesis is critical for successful mosquito stage development.
This study reveals that diverse heterotrophic marine bacteria from the Baltic Sea emit a broadly conserved core set of volatile organic compounds, primarily acetone, alongside strain-specific low-abundance compounds, suggesting a widespread and phylogenetically independent contribution of these microbes to marine atmospheric chemistry.
This study demonstrates that room temperature liquid phase backscattered electron scanning electron microscopy (LPBSEM) using graphene liquid cells enables high-contrast, stain-free visualization of native hydrated *Bacillus subtilis* spore substructures, validated by Monte Carlo simulations and optimized beam energy conditions.
This study comprehensively characterizes the genomic diversity, antibiotic resistance profiles, and horizontal gene transfer potential of 441 respiratory *Escherichia coli* strains from swine across China, revealing a high prevalence of multidrug resistance genes—including critical "last-resort" variants—facilitated by plasmids and an open pangenome, which underscores the significant risk these strains pose as reservoirs for antimicrobial resistance transmission to humans and the environment under a One Health framework.
This study reports the discovery of eight novel monosegmented, bicistronic RNA viruses belonging to the genera *Totivirus* and *Eimeriavirus* in the smut fungus *Thecaphora thlaspeos*, revealing a complex and variable mycovirome that expands the known diversity of viruses in Ustilaginomycotina.
This study reveals that the coronavirus envelope protein (CoV-E) hijacks the TAp73-FDXR axis by inducing TAp73 degradation, which impairs iron-sulfur cluster synthesis and triggers a false perception of iron deficiency leading to iron overload, while identifying the molecule DPTP-FC as a promising therapeutic candidate to block this interaction and alleviate tissue damage.
This study demonstrates that an integrative and conjugative element (ICE) in *Novosphingobium aromaticivorans* facilitates frequent, directional, and localized chromosomal DNA recombination between strains of the same species, thereby enhancing adaptive potential while reinforcing species boundaries by restricting such exchange to intraspecific interactions.