816 papers
This study reveals that microbial communities at the Atlantic ocean-air interface exhibit distinct taxonomic structures and a latitudinal diversity gradient increasing toward the equator, driven by terrestrial air masses and characterized by selective, rather than random, exchange of microbial lineages between the ocean and atmosphere.
This study demonstrates that alkaline phosphatase activity in coastal marine environments persists even when phosphate is abundant and reveals that the bacterium *Ruegeria pomeroyi* utilizes this enzyme not only for phosphorus acquisition but also as a stress response to facilitate the uptake of organic carbon from dissolved organic phosphorus compounds.
This study establishes *Galleria mellonella* larvae as a practical in vivo model for investigating *Bilophila wadsworthia* virulence, demonstrating that systemic infection via hemolymph injection—rather than oral colonization—induces significant morbidity through intracellular bacterial replication and dynamic immune cell interactions.
This study presents a genome-resolved metagenomic dataset from the historic Morrow Plots long-term experiment, revealing 230 metagenome-assembled genomes that highlight the dominance of archaeal ammonia oxidizers and their management-associated ecological patterns in agricultural soils.
This study demonstrates that lytic bacteriophages can infect non-replicating bacteria through a transient state of pseudolysogeny to eliminate persistent and CRISPR-resistant implant infections in mice, highlighting the critical role of bacterial defense mechanisms in phage therapy design.
This study demonstrates that the amphipathic membrane targeting sequence (MTS) of *Pseudomonas aeruginosa* RNase E is essential for proper RNA degradosome morphology and dynamics, thereby regulating transcriptome organization, stress response, and bacterial virulence.
This study introduces the Cultivated Complete Genome Reference (CCGR), a compendium of 1,150 fully circularized human gut bacterial genomes that reveals how mobile genetic elements and chromosomal architecture drive strain-level functional diversity, exemplified by a plasmid-encoded gene essential for mitigating fructose-induced colitis.
This paper presents the development and hardware qualification of ExocubeBio, a miniaturized fluidic platform scheduled for the International Space Station in 2027 that combines autonomous in-situ optical monitoring of microbial exposure with the capability to return preserved samples to Earth for post-flight analysis.
This study reveals that in *Neurospora crassa*, a cytosolic GH18 endo-β-N-acetylglucosaminidase (ENGase) rather than a putative acidic PNGase serves as the active deglycosylating enzyme essential for ER-associated degradation, fungal stress tolerance, and proteostasis.
This study utilizes single-cell transcriptomics and transgenic reporter lines to reveal that a Myb-dominated gene regulatory network universally governs the irreversible commitment to gamete differentiation and subsequent size expansion in diatoms, thereby elucidating the molecular mechanisms underlying their complex life cycles and global ecological significance.
This study demonstrates that intracellular polyhydroxybutyrate (PHB) granules serve as a critical carbon reserve enabling the marine bacterium *Phaeobacter inhibens* to survive prolonged starvation, highlighting a conserved survival strategy among algal-associated bacteria in fluctuating ocean environments.
This study reveals that phage infectivity in *Mycobacterium abscessus* is primarily determined by host lipid metabolic pathways and mycomembrane architecture rather than a single dedicated receptor, with resistance arising through diverse genetic mutations that impair phage adsorption.
This study characterizes the broad human cell tropism of the emerging Oropouche virus, demonstrating its ability to cross the blood-brain barrier without disrupting integrity and causing significant neuronal vulnerability, thereby providing a foundation for understanding its neuroinvasive mechanisms.
This study demonstrates that the oral bacterial lysate OM-89 enhances intracellular clearance of uropathogenic *E. coli* in bladder epithelium by promoting lysosomal acidification and protease activity, thereby synergizing with antibiotics to reduce bacterial regrowth and offering a promising host-directed strategy for managing recurrent urinary tract infections.
This study demonstrates that SARS-CoV-2 defective viral genomes (DVGs) originating from distinct genomic hotspots differentially regulate innate immunity, as DVGs from hotspot B uniquely induce robust interferon responses and suppress wild-type virus replication compared to those from hotspot A, thereby influencing viral pathogenesis.
This study demonstrates that deploying portable, offline metagenomic sequencing in Burundi reveals that syndromic cholera diagnoses often mask diverse diarrheal etiologies, primarily *Escherichia coli*, while enabling rapid, on-site detection of *Vibrio cholerae*, its toxin, and antimicrobial resistance to improve outbreak response in resource-limited settings.
This study reveals that *Mycobacterium tuberculosis* and *M. smegmatis* exhibit metabolic flexibility in peptidoglycan recycling by utilizing a previously undescribed pathway to incorporate 2-modified MurNAc that bypasses both the canonical *E. coli*-type and *Pseudomonas*-type mechanisms.
This study demonstrates that IFN-β acts as a critical, protective epithelial mediator during Chlamydia muridarum infection by restricting bacterial replication and regulating immune responses through a TLR3-dependent signaling axis, thereby reconciling its protective role with conflicting reports on type I interferon-mediated immunopathogenesis.
This study reveals that *Proteus mirabilis* strains exhibit significant variation in chondroitin sulfate degradation kinetics and regulation, with urea repressing this process in specific strains via urease activity and unique endolyase mutations, ultimately diminishing the contribution of chondroitin sulfate degradation to virulence in a mouse model of catheter-associated urinary tract infection.
This paper introduces ZeaMiC, a publicly available culture collection of 88 maize root-associated bacteria selected for their ecological relevance and functional potential, to serve as a vital resource for mechanistic studies of plant-microbe and microbe-microbe interactions.