816 papers
This study identifies ISPpu10 as a novel IS110-family recombinase that utilizes a unique structure-gated bridge RNA mechanism to drive safe, large-scale genomic rearrangements and payload integration in *Pseudomonas putida*, offering a high-stringency tool for synthetic biology.
This study analyzes 154 bacteriophages across seven host genera to demonstrate that virulent phages with numerous tRNA genes exhibit greater codon usage divergence from their hosts, particularly in Gram-negative systems, while revealing that previous findings based solely on *Mycobacterium* phages do not generalize to broader phage-host interactions.
This study reveals that *Leishmania* exploits the host endoplasmic reticulum-shaping protein CLIMP-63 to reprogram mitochondrial biogenesis and bioenergetics, thereby facilitating successful infection of macrophages.
Serial passage of the beneficial bacterium *Pseudomonas protegens* CHA0 through insect larvae did not compromise its multi-host lifestyle or biocontrol capabilities, demonstrating that its ability to protect plants and kill insects remains stable even after forced adaptation to an insect-only environment.
This study utilizes full-length 16S rRNA PacBio sequencing to characterize the bacterial microbiome of freshwater centrohelid heliozoans, revealing a core community dominated by specific Proteobacteria and Bacteroidia while providing the first evidence that these protists harbor opportunistic pathogens and Rickettsiaceae, thereby serving as potential environmental reservoirs for bacteria with pathogenic potential.
This study identifies the ER-resident protein STEEP1 as a specific host dependency factor essential for Epstein-Barr virus LMP1 trafficking from the endoplasmic reticulum to signaling sites and subsequent activation of growth pathways, highlighting the LMP1/STEEP1 interaction as a novel therapeutic target.
This study utilizes AI-predicted protein structures and metagenomic analysis to discover and experimentally validate a previously unknown Chlorophyll a degradation pathway in diverse prokaryotes, demonstrating the power of structure-based homology detection in uncovering global metabolic capabilities.
This study identifies human monoclonal antibodies generated by *Plasmodium falciparum*-infected mosquito bites that target the mosquito salivary protein SG1L3 bound to sporozoites, revealing it as a potential serological marker for mosquito exposure rather than a viable target for blocking malaria infection.
This study reveals that the plant pathogen *Agrobacterium fabrum* C58 modulates its extracellular vesicles under virulence-inducing conditions to deliver Type IV and Type VI secretion system effectors directly into plant cells to enhance tumor formation, while also influencing environmental bacteria and eliciting distinct host metabolome responses.
In *Aspergillus fumigatus*, thermal adaptation to elevated temperatures reduces levels of the lncRNA afu-182, which negatively regulates heat-shock proteins and correlates with increased azole resistance and worse disease outcomes in murine models of invasive pulmonary aspergillosis.
This study utilizes comparative genomics of 13 *Vibrio* strains associated with *Porites cylindrica* white syndrome to reveal that their virulence potential is driven by a conserved core of extracellular enzymes and lineage-specific modules shaped extensively by horizontal gene transfer via mobile genetic elements.
This study identifies and characterizes novel *Candidatus* Methanoborealis (ANME-2a) genomes from Baltic Sea sediments, demonstrating their specific genomic potential for metal-coupled anaerobic methane oxidation via extracellular electron transfer and confirming their active role in metal reduction during methane consumption.
This study utilizes cryo-EM to elucidate how receptor binding triggers conformational changes in the baseplate of *Staphylococcus* phage 812, initiating a cascade that releases peptidoglycan-degrading domains and drives tail sheath contraction to deliver the viral genome into the host.
This study demonstrates that plant colonization by root-associated bacteria, such as *Streptomyces* and *Pseudomonas*, elicits the biosynthesis of the antifungal compound DHP through specific plant-derived signals like L-valine and brassinosteroids, thereby enhancing plant resilience against fungal pathogens.
This study demonstrates that Type 2 diabetes exacerbates vaginal Group B Streptococcus colonization in mice by impairing the mucosal pro-inflammatory cytokine response, particularly IL-1, which can be reversed by local IL-1 supplementation to resolve the infection.
This study demonstrates that revegetation of former grazing lands drives sequential, timescale-dependent shifts in soil microbial functions and life-history strategies, with rapid early recovery of core health processes like nutrient retention and carbon fixation followed by a gradual development of plant growth-promoting traits.
This study identifies the female-enriched gut bacterium *Eggerthella lenta* as a causal driver of neuroinflammation and multiple sclerosis severity in women by activating the host receptor TLR2 to induce IFN-γ production, thereby elucidating a key mechanism behind sex differences in autoimmunity.
This study reveals that a natural bacterial consortium from Galveston Bay achieves synergistic PET degradation through an ancestral hydrocarbon metabolism repurposed via metabolic division of labor and horizontal gene transfer, enabling the complete conversion of plastic oligomers into terephthalic acid.
This study successfully isolated and characterized biosurfactant-producing bacteria from industrial waste near Dhaka, Bangladesh, identifying strains from genera such as *Bacillus* and *Pseudomonas* that exhibit promising eco-friendly properties for bioremediation and diverse industrial applications.
This study demonstrates that while broad-spectrum CDK inhibitors consistently suppress gammaherpesvirus reactivation and replication, targeted CDK 4/6 inhibitors exhibit stage-dependent effects that decrease reactivation when administered concurrently but increase it when given prior to induction, suggesting their therapeutic potential for virus-associated cancers depends critically on treatment timing.