816 papers
This study reveals that cooperative siderophore exchange between the yeast *Rhodotorula kratochvilovae* and commensal *Pseudomonas* species stabilizes the leaf microbiome and protects plants against pathogens by selectively promoting beneficial bacterial growth through specific iron-uptake mechanisms.
This study reveals that *Staphylococcus aureus* exploits the nutrient-rich intracellular environment of differentiated osteoclasts—specifically by utilizing glutamine and carbon metabolism pathways—to replicate effectively while evading a blunted host antimicrobial response.
This study identifies twenty-seven bacterial species and one fungus, including twenty previously unreported colonizers, in metalworking fluids from two locations, analyzing their growth, health risks, contamination pathways, and roles in hydrocarbon degradation.
This study identifies Component A2 as a redox-sensitive, MCR-dependent archaeal ATPase that utilizes a distinctive N-terminal zinc-binding motif to hydrolyze ATP and drive the conformational changes necessary for the reductive activation of methyl-coenzyme M reductase.
This study demonstrates that in *Pseudomonas aeruginosa*, cell surface hydrophobicity drives micron-scale spatial segregation within aggregates, which physically excludes cheaters from cooperative clusters and thereby stabilizes social traits in chronic infection environments.
This study demonstrates that co-culturing green algae with environmentally harvested bacteria significantly extends crop survival against fungal infection by up to 350%, offering a cost-effective alternative to chemical antifungals for large-scale algal biofuel production.
This study demonstrates that the gut commensal *Odoribacter splanchnicus* mitigates pathogenesis and inflammation caused by *Salmonella* and *Listeria* through a secreted bacteriocin that inhibits biofilm formation, virulence gene expression, and intracellular replication, highlighting its potential as a broad-spectrum therapeutic agent.
This study reveals that *Staphylococcus aureus* bypasses the lethality of a *plsX* deletion through cooperative mutations in *fabF* and *fadM* that facilitate the premature release and recycling of fatty acids, thereby enabling phospholipid synthesis while concurrently increasing sensitivity to -lactam antibiotics.
This study benchmarks four targeted enrichment methods for whole-genome sequencing of low-abundance Influenza A virus in wastewater, identifying ultrafiltration as the optimal concentration strategy and revealing that while custom tiled-amplicon panels offer a cost-effective solution for known seasonal variants, probe-capture methods provide superior resilience for detecting emerging strains despite higher costs.
This study demonstrates that cotton fabrics functionalized with hydroxyl-rich graphene derivatives and silver nanowires, particularly through combined HGO/AgNWs treatment, exhibit partial washing resistance and preliminary antibacterial activity against *Escherichia coli*.
This study demonstrates that iron limitation alters diatom-bacterial carbon flow by shifting bacterial metabolism toward the consumption of specific exudates like aromatics and nucleotides, driven by changes in both exudate composition and microbial community structure.
This study demonstrates that the carcinogenic activity of high-risk HPV E7 relies on the cooperative inactivation of two distinct tumor suppressors, RB1 and PTPN14, as neither mutant alone could immortalize keratinocytes, but their combined deficiency restored this capability.
By combining structural modeling with functional assays, this study identifies vulnerable, antibody-accessible sites on the membrane-distal side of the Plasmodium P36-P52 heterodimer that, when targeted, effectively block sporozoite invasion of hepatocytes, highlighting the complex as a promising candidate for next-generation pre-erythrocytic malaria vaccines.
This study establishes a validated in vitro infection system using caecal organoids (caecaloids) that successfully supports the sustained growth and morphological development of *Trichuris muris* larvae, demonstrating that the caecaloid epithelium alone is sufficient to recapitulate key aspects of whipworm development observed in vivo.
This study demonstrates that the recently detected *Plasmodium falciparum* K13 C580Y mutation in Ethiopian isolates functionally confers artemisinin tolerance, as validated by CRISPR-Cas9 genome editing and ring-stage survival assays.
This study demonstrates that resistance to Type 6 Secretion System (T6SS) toxins is highly specific to the toxin class, with distinct genetic mutations conferring protection against particular toxins (such as amidases or lipases) while simultaneously increasing susceptibility to others, thereby creating evolutionary trade-offs that likely maintain the widespread prevalence of T6SS weaponry in microbial competition.
This study demonstrates that human cell F-actin density differentially regulates Entamoeba histolytica ingestion, where reduced cortical F-actin specifically enhances phagocytosis while trogocytosis is suppressed across all cytoskeletal mutants, revealing a more complex relationship than previously suggested by artificial stiffening models.
The study introduces ARG-PASS, a novel method leveraging conserved protein sequence-structure signatures to successfully identify and experimentally validate previously undetected antibiotic resistance genes, including pre-resistance determinants, within the human microbiome and AlphaFold database.
This study reveals that *Vibrio cholerae* overcomes growth defects caused by the loss of its primary Na+/H+ antiporter and Na+-NQR through suppressor mutations that either upregulate the *nhaB* antiporter or alter the expression and DNA-binding activity of the moonlighting aminopeptidase PepA, thereby identifying PepA as a novel regulator of sodium homeostasis.
TracePheno is a function-first framework that infers interpretable, publication-ready phenotypes for eight essential trace elements from microbiome gene or KO profiles by utilizing curated marker tiers and explicit decision rules to overcome the limitations of taxonomy-based analysis.