816 papers
This study reveals that primate TRIM5α proteins restrict most tick-borne orthoflaviviruses but fail to inhibit Powassan virus due to a specific NS3 mutation that enables high replication, ultimately demonstrating that TRIM5α-mediated restraint of viral replication serves as a mechanism to avoid triggering strong early innate immune responses.
This study introduces a high-throughput functional screening platform that captures and phenotypically tests integron gene cassettes from food and fertiliser samples, successfully uncovering novel antimicrobial resistance genes and hidden reservoirs of adaptive traits that remain undetected by traditional sequence-based methods.
This pilot study characterizes the respiratory microbiota of blue, fin, and humpback whales in the Gulf of St. Lawrence, demonstrating that blow microbiome diversity serves as a non-invasive biomarker for individual health, with higher diversity correlating with better skin condition and lower pathobiont abundance.
This study introduces a computationally efficient, host-response-based framework that quantifies interferon-stimulated gene expression to rapidly identify hidden viral infections across approximately 210,000 diverse animal RNA-seq datasets, effectively detecting highly divergent viruses that conventional homology-based methods often miss.
This study investigates a fatal EEHV1B infection in a captive Asian elephant by analyzing viral dynamics, tissue viral loads, and comparative genomics, revealing high viral loads, optimal sample preservation methods, and evidence of recombination between EEHV subspecies that may impact disease pathogenesis and diagnostics.
This study demonstrates that the Galleria mellonella infection model serves as a reliable, scalable, and cost-effective alternative to mouse models for assessing population-level virulence trends in Pseudomonas aeruginosa, showing a strong correlation with mouse bacteremia results, whereas epithelial cell cytotoxicity assays exhibited a weaker correlation.
This study demonstrates that free-living amoebae act as transient, non-replicative hosts for pathogenic and saprophytic *Leptospira* spp., facilitating their environmental persistence and suggesting a potential role for these protozoa in the ecological maintenance and transmission of leptospirosis.
This study demonstrates that the antiviral drug favipiravir completely protects against lethal Oropouche virus infection in a hamster model by suppressing viral replication and preventing fatal neuroinvasion, while transcriptomic analysis reveals that effective treatment abrogates the virus-induced inflammatory and metabolic disruptions responsible for pathogenesis.
This study demonstrates that introducing microbial communities from natural freshwater oil seeps into contaminated environments significantly accelerates the degradation of anthropogenic oil spills, offering a promising nature-based strategy for spill mitigation.
This study identifies the epigenetic regulator IngB in *Aspergillus fumigatus* as a key factor controlling azole tolerance, demonstrating that its loss facilitates the rapid emergence of acquired antifungal resistance through an epistatic mechanism.
This study establishes that host age is the primary determinant of disease severity in ferrets infected with two distinct genotypes of Severe Fever with Thrombocytopenia Syndrome virus (SFTSV), with older animals exhibiting rapid, lethal progression compared to the milder, delayed symptoms in younger ferrets, thereby validating an age-stratified ferret model for evaluating SFTSV countermeasures.
This study identifies the L,D-transpeptidase LdtB as a critical enzyme for *Mycobacterium tuberculosis* acid resistance and intracellular survival by maintaining peptidoglycan integrity, revealing it as a promising target to enhance the efficacy of beta-lactam antibiotics during infection.
This study reveals that the periplasmic protein YdbL maintains *Escherichia coli* outer membrane homeostasis by directly interacting with the lipoprotein YnbE to modulate the formation of the YdbH-YnbE intermembrane bridge essential for phospholipid transport.
This study introduces the Eco-tank, a pathogen-monitored semi-natural housing system that restores ecological complexity to laboratory mice, thereby rewilding their gut microbiomes and enhancing baseline immune resistance without compromising adaptive immunity to better align preclinical models with natural immune phenotypes.
This study reveals that the temperate phage VP882 exploits *Vibrio parahaemolyticus* quorum sensing to optimize its transmission by overcoming host defenses through superinfection and superlysogenization, while the host simultaneously attempts to block attachment via polysaccharide shielding at high cell densities.
This study reveals that symbiotic sulfate-reducing bacteria in gutless marine worms have evolved a distinct, oxygen-tolerant metabolic profile characterized by the retention of core functions, the loss of nutrient-scavenging mechanisms, and the expression of the glyoxylate bypass, resulting in larger genomes that support metabolic versatility within their host-associated environment.
This study reveals that the early branching apicomplexan parasite *Cryptosporidium parvum* possesses a unique holocentric chromosome structure characterized by numerous GA-rich CENH3 binding sites scattered across all chromosomes, a feature distinct from the regional centromeres found in related species.
This study characterizes *Streptomyces albidoflavus* MD102 as a highly tractable, fast-growing microbial chassis and optimizes it via CRISPR/Cas9-mediated genome reduction and strategic gene insertions to enhance its capacity for the heterologous production of diverse secondary metabolites.
This study utilized a scalable high-throughput screening platform to map thousands of phage-antibiotic interactions in clinical *E. coli* and *K. pneumoniae* isolates, revealing species-specific synergy patterns that challenge taxonomic predictions and provide a foundation for rational combination therapies against multidrug-resistant urinary tract infections and urosepsis.
By reconstructing 12,789 genomes from 152 samples across 49 geothermal springs in Tengchong, this study reveals how pH and temperature drive community assembly into distinct groups and shape simplified yet efficient microbial interaction networks, offering comprehensive insights into the diversity and function of these extreme ecosystems.