552 papers
Microbiology explores the invisible world of tiny life forms that shape our health, environment, and even the air we breathe. From bacteria and viruses to fungi and parasites, this field investigates how these microscopic organisms interact with us and each other, driving everything from disease outbreaks to beneficial fermentation processes. Understanding them is crucial for developing new medicines, improving food safety, and combating global health challenges.
At Gist.Science, we make the latest discoveries in this dynamic field accessible to everyone. We process every new preprint uploaded to bioRxiv in this category, transforming dense academic findings into both clear, plain-language explanations and detailed technical summaries. This ensures that whether you are a student, a researcher, or simply curious, you can grasp the significance of cutting-edge science without getting lost in jargon.
Below are the most recent papers in microbiology, curated and summarized directly from the bioRxiv server to keep you at the forefront of discovery.
This study reveals that wastewater treatment plant discharges, particularly those containing hospital effluent, drive a progressive downstream increase in antimicrobial resistance genes along Switzerland's Aare River, while major tributaries sustain these elevated levels and lakes significantly reduce them.
This study demonstrates that specific pathoadaptive mutations and increased glycosylation patterns in the G protein of RSV-A GA2.3.5 isolates correlate with enhanced viral replication and greater disease severity in hospitalized infants, highlighting their potential as targets for future surveillance and immune-based interventions.
This study utilizes LC-MS/MS secretome analysis to demonstrate that *Bacillus toyonensis* Bto_UNVM-42 secretes pesticidal protein homologs and degradative enzymes, providing proteomic evidence that extracellular components contribute to its nematicidal activity and challenging the traditional view of these proteins as solely intracellular.
This paper presents the development and validation of two economical, high-throughput immunoassays (CBA and SIA) capable of sensitively and specifically detecting LCMV antibodies in mouse serum, thereby offering scalable tools for zoonotic surveillance, outbreak preparedness, and the study of viral transmission dynamics.
This study demonstrates that engineered *Bacillus subtilis* probiotics expressing lactate oxidase can acutely improve host energy balance and sepsis survival by rewiring microbiome metabolism toward anabolic processes, but these beneficial effects fail to persist chronically due to homeostatic compensation, highlighting a clear timescale-dependent limit to gut-centric metabolic therapies.
This study introduces a joint Bayesian latent-variable model that integrates parasite density, gametocyte density, and mosquito infectivity to quantify their interlinked relationships and measurement uncertainties in *Plasmodium vivax* transmission, revealing that while gametocyte density is the primary driver of infectivity, asexual parasite density provides significant additional predictive information.
This study demonstrates that Escherichia coli ST131 evades phage killing in urine through quorum sensing and capsule expression, but a rationalized therapy combining depolymerase-encoding phages, multi-receptor targeting, specific carbon sources, and simulated bladder washes can effectively overcome these resistance mechanisms to sterilize bacterial cultures.
This study demonstrates that Oxford Nanopore long-read sequencing achieves comparable accuracy to Illumina short-read sequencing for *Mycobacterium tuberculosis* lineage assignment, antimicrobial resistance prediction, and outbreak detection, thereby validating the aggregation of data from both platforms for large-scale public health surveillance.
This study demonstrates that Epstein-Barr Virus (EBV) exposure suppresses anti-tumor interferon production in human microglia while upregulating proto-oncogenic genes, revealing a potential mechanism by which EBV contributes to central nervous system malignancies in immunocompromised individuals.
This study utilizes a high-throughput genetic screen to demonstrate that nutrient availability regulates *Staphylococcus aureus* extracellular vesicle production through the *agr* quorum sensing system, linking metabolic stress to vesiculogenesis.