826 papers
This study characterizes the global proteomic adaptations of the White-Nose Syndrome pathogen *Pseudogymnoascus destructans* to chronic copper stress, revealing distinct molecular responses to copper deprivation and overload while validating specific protein targets for stress detection via western blotting.
By integrating multi-omics and geochemical data from three meromictic lakes, this study reveals that the decoupling between the abundance and activity of sulfur-cycling bacteria is driven by distinct viral infection strategies, where temperate viruses sustain purple sulfur bacteria while lytic viruses suppress green sulfur bacteria.
This study reports the first isolation of the multidrug-resistant fungal pathogen *Candida auris* from Antarctic marine microplastics, revealing its cold-adapted traits, nylon-binding affinity, and a mutator phenotype that drives its rapid global evolution and emergence of distinct drug-resistant clades.
This study demonstrates that the *scs* pilus in *Stenotrophomonas maltophilia* acts as a context-dependent regulator of adhesion and virulence, where its functional significance becomes apparent through genetic interactions with other surface structures and infection-relevant conditions rather than under standard laboratory settings.
This study reveals that the marine phoronid *Phoronopsis harmeri* and its tubes host distinct, less diverse microbial communities dominated by sulfur-cycling bacteria compared to the surrounding sediment, suggesting a potential functional link between these microbiomes and the host's chemical defenses.
This study establishes a comprehensive genomic resource of bacterial and phage genomes from *Zostera marina* seagrass leaves, revealing a diverse viral catalog with predicted auxiliary metabolic genes linked to carbon utilization that underscores the potential role of viruses in seagrass carbon cycling and blue carbon management.
This study presents the draft genome of *Colletotrichum* sp. CLE4, a seagrass-associated fungus within the *C. acutatum* complex, revealing a streamlined genome with reduced gene content that likely reflects its evolutionary adaptation to a specialized marine monocot host.
This study utilizes deep metagenomic sequencing of *Zostera marina* to recover five eukaryotic metagenome-assembled genomes, including a novel chytrid in the order Lobulomycetales whose genomic features suggest a symbiotic relationship with the seagrass.
This study reveals that the *Mycobacterium tuberculosis* sensor kinase PdtaS senses chemically diverse ligands like copper and nitric oxide by inhibiting its dimerization, thereby repressing its constitutive autophosphorylation activity through a conserved GAF/PAS dimer interface rather than specific ligand-binding pockets.
This study employs an integrative bioinformatics and machine learning pipeline to identify a candidate pathogenicity island in *Fusobacterium nucleatum* and proposes a novel mechanistic hypothesis linking hemolysin-mediated iron acquisition to cancer progression via oxidative stress and Hippo pathway modulation.
This study systematically characterizes PBP2 subtype substrate-binding proteins as the primary siderophore recognizers in Gram-positive bacteria, revealing their widespread presence, genomic decoupling from synthetases, and coordinated iron-responsive regulation to enable large-scale inference of microbial iron acquisition networks.
This study identifies the divergent Plasmodium kinase NEK4 as a critical regulator that couples meiotic initiation with zygote morphogenesis by localizing to the microtubule-organising center to orchestrate nuclear migration, microtubule assembly, and the transcriptional and phosphoregulatory networks essential for early meiosis and ookinete development.
This study introduces a dynamics-led computational pipeline that utilizes high-resolution time-series data and unsupervised clustering to quantify transient dynamics and inoculum effects in *Pseudomonas aeruginosa*, revealing a novel ODE model that captures complex antibiotic behaviors and defines new metrics for distinguishing dynamical regimes.
This comprehensive survey of 363 table olive samples from six countries reveals that while processing methods (alkali-treated vs. natural fermentation) are the primary drivers of microbial community structure, high variability caused by stochastic colonization and small-scale production obscures variety-specific signatures, thereby highlighting the need for microbiome-based starter cultures to harness the untapped potential of these diverse bacterial and fungal communities.
This study identifies human gut microbiome-derived antimicrobial peptides, particularly amp21 and amp6, that effectively disrupt *Pseudomonas aeruginosa* biofilms by targeting specific lectin proteins (LecA and LecB) through a combination of computational screening, molecular dynamics simulations, and in vitro validation, ultimately leading to the design of even more potent ultrashort peptides.
This study analyzes the gut virome of 714 mother-infant pairs in the Lifelines NEXT cohort to establish the maternal origin and rapid diversification of the infant virome, identify delivery and feeding modes as key developmental drivers, link increased viral diversity to food allergies, and uncover genetic mechanisms enabling long-term viral persistence.
This paper critiques Hariharan et al.'s 2025 study on naturally occurring defective HIV genomes, arguing that their observational data cannot validly assess the therapeutic potential of interfering particles, that their reported reproductive numbers are internally inconsistent with viral dynamics, and that established alternative mechanisms better explain the observed phenomena.
GradeBins is an open-source, low-overhead framework that enhances metagenomic bin quality control by providing standardized, reproducible per-bin and bin-set summaries in both inference and ground truth modes, thereby enabling objective benchmarking and consistent quality reporting across diverse microbial communities.
This study demonstrates that GM-CSF-differentiated macrophages are highly permissive to Chikungunya virus infection and support robust viral replication, whereas M-CSF-differentiated macrophages resist infection by mounting a potent antiviral state characterized by elevated IFN-alpha and CXCL10 production driven primarily by dsRNA sensing.
This study describes *Thalassoporum longitrichum* sp. nov., a novel marine epizoic cyanobacterium characterized by a polyphasic approach that confirms its distinctiveness while simultaneously proposing the synonymization of the genus *Limnothrix* into *Pseudanabaena*, and highlights the new species' non-toxic, pigment-rich profile and significant anti-inflammatory potential.