829 papers
This study demonstrates that both genetic deletion and pharmacological inhibition of the peptidoglycan hydrolase SagA impair cell wall remodeling in vancomycin-resistant *Enterococcus faecium*, thereby restoring its susceptibility to vancomycin.
This pilot study demonstrates that household-scale urban Bokashi composting is dominated by beneficial lactic acid bacteria, effectively converts food waste into nutrient-rich organic acids for plant growth without significantly altering soil microbiomes or posing substantial health risks from pathogens.
This study reveals that the mycobacterial lipoglycan mannose-capped lipoarabinomannan (ManLAM) drives macrophage foam cell formation and lipid metabolic reprogramming in tuberculosis by simultaneously engaging Toll-like receptor 2 and Dectin-2 through distinct structural moieties, thereby activating an mTORC1-PPAR-dependent pathway that is largely independent of NF-B signaling.
This study reveals that *Mycobacterium smegmatis* develops resistance to phage D29 through IS6120-mediated promoter reconstitution, which inserts a stronger promoter upstream of the *mpr* gene to drive toxic overexpression of the Mpr exonuclease and block phage infection.
By analyzing over 4,000 global soil datasets, this study reveals that soil *Legionella* diversity and pathogen abundance are strongly shaped by climatic gradients, with warmer and wetter conditions favoring the detection of various pathogenic lineages beyond the commonly monitored *L. pneumophila*.
This study identifies AbjA, a novel recipient-based defense factor that uniquely triggers an abortive conjugation mechanism by directly targeting the Type IV secretion system's TrbE ATPase to induce cell death, thereby preventing plasmid transfer and offering new insights into bacterial immunity and the spread of antibiotic resistance.
This paper presents a scalable, parallelized 2x2 electrode array microscope system that rapidly determines bacterial viability by detecting fluorescence changes in response to electrical stimulation, offering a promising solution for accelerating antimicrobial susceptibility testing.
This study demonstrates that the legacy 4(1H)-quinolone ICI 56,780 effectively targets both acute and chronic stages of *Toxoplasma gondii* by inhibiting mitochondrial electron transport, thereby reducing parasite viability and brain cyst burden in mice despite some pharmacokinetic limitations.
This study introduces a five-species gastric microbial model community to investigate how interactions with other bacteria, such as resource competition and pH modulation, influence *Helicobacter pylori* colonization and pathogenesis, offering a non-invasive platform for future gastric microbiome research.
This study utilizes mass spectrometry and SILAC to demonstrate that doxycycline inhibits both apicoplast and mitochondrial translation in apicomplexan parasites, thereby disrupting oxidative phosphorylation and revealing its dual mechanism of action beyond the previously known apicoplast-specific effects.
This study reveals that sacbrood virus and deformed wing virus differentially modulate honey bee flight performance through the octopamine signaling pathway, where octopamine supplementation rescues flight deficits in deformed wing virus-infected bees but impairs performance in sacbrood virus-infected bees.
This study identified a set of structurally similar molecules that selectively bind the *prfA* thermosensor RNA in *Listeria monocytogenes* with high affinity but fail to inhibit translation, providing a promising scaffold for future drug development against antimicrobial resistance.
This study demonstrates that while a specific *ssrA* SNP enhances *speA* expression and contributes to the global expansion of the *Streptococcus pyogenes* M1UK lineage, the resulting phenotype is not solely determined by this mutation, as read-through and toxin production can occur in its absence and are likely modulated by a complex regulatory network involving CovRS.
While this study demonstrates that pathogenic and commensal *Enterococcus* species can suppress *C. difficile* growth in vitro through carbon source-dependent acidification, it reveals that this mechanism fails to prevent *C. difficile* colonization in a VRE-dominated mouse gut when supplemented with fermentable sugars, suggesting that therapeutic pH reduction in the mammalian intestine requires more sophisticated approaches.
This study introduces a computational framework that screened over 37,000 eukaryotic genomes to identify hundreds of thousands of endogenous double-stranded DNA viral regions, revealing their widespread presence across diverse species and uncovering numerous novel virus-host associations that expand our understanding of the endogenous dsDNA virosphere.
This study demonstrates that microbial communities maintain robust growth under environmental stress, such as increased salinity, by shifting their composition toward faster-growing species, a mechanism validated through experiments, modeling, and natural metagenomic data.
A study demonstrates that the LP.8.1-directed mRNA vaccine booster not only durably elevates neutralizing antibody titers against its target and recent variants like XFG but also, for the first time since 2022, successfully mitigates ancestral immune imprinting by eliciting higher responses against the vaccine strain than the ancestral D614G.
This study utilizes a combined approach of top-down proteomics and mass spectrometry imaging to map the spatial proteomic landscape of *Bacillus subtilis* biofilms, successfully demonstrating the detection of differentiated subpopulations through proteoforms and revealing the localization of post-translational modifications at the microscale.
This study demonstrates that encapsulating chiral histidine-modified gold nanoclusters within cationic lipid nanoparticles creates a stable, highly effective platform that synergistically disrupts *S. aureus* biofilms and reduces bacterial burden in device-associated infections through combined redox stress and matrix destabilization.
This study identifies anthracycline compounds as effective antivirals against HCoV-OC43 by demonstrating that they selectively bind to and inhibit the virus's -1 programmed ribosomal frameshifting element, thereby reducing infection.