microbiology papers | Gist.Science

The transcriptional response of Yersinia pseudotuberculosis to macrophage-released chemicals during growth within synthetic microcolonies

This study reveals that *Yersinia pseudotuberculosis* microcolonies exhibit spatially distinct transcriptional responses to macrophage-derived factors, where peripheral bacteria primarily activate nitrosative stress and prophage genes while the entire colony upregulates itaconate degradation, though only a subset of colonies encounters sufficient itaconate to significantly impact bacterial fitness.

Clark, S. A., Palmer, A. D., Huo, W. + 5 more2026-03-26🦠 microbiology

Overcoming Protein A-driven Nonspecific Antibody Staining of S. aureus in Immunofluorescence Microscopy

This study demonstrates that using human serum as a blocking agent and antibody diluent is a robust, cost-effective strategy to overcome Staphylococcus aureus Protein A-driven nonspecific antibody staining, thereby significantly improving the accuracy of immunofluorescence microscopy in infection models.

Gauthier, L., Löffler, B., Figge, M. T. + 2 more2026-03-26🦠 microbiology

Viral isolation reveals novel and diverse phages infecting natural stream biofilms

This study introduces the Alpine Lotic Phage (ALP) collection, a diverse set of 28 novel tailed phages isolated from alpine stream biofilms that infect 14 bacterial species and exhibit unique genomic and functional characteristics, thereby providing a foundational resource for exploring phage ecology and evolution in natural environments.

Chin, W. H., Boutroux, M., Harding, A. + 3 more2026-03-26🦠 microbiology

Integrated omics analysis reveals reorganization of nitrogen and lipids metabolism in a toluene-degrading bacterium

This study employs integrated omics analysis to reveal that the toluene-degrading bacterium *Acinetobacter* sp. Tol 5 adapts to gas-phase, water-limited conditions by reorganizing its metabolism to promote amino acid and nucleic acid degradation, accumulate citrulline as a stress response, and utilize intracellular storage lipids for survival.

Inoue, S., Naobayashi, T., Tokiyoshi, K. + 3 more2026-03-26🦠 microbiology

Who Formed All That Iron?: A Novel Antarctic Chemolithotroph Drives Iron Biomineralization

This study identifies a novel Antarctic chemolithotroph, *Candidatus Mariimomonas ferrooxydans*, as a key driver of dark, anoxic iron biomineralization, providing genomic and functional evidence that challenges phototroph-centric models of banded iron formation and offering a modern analogue for understanding Earth's early geochemical history and potential extraterrestrial iron deposits.

Yoon, J., Lee, B., Yoo, K.-C. + 9 more2026-03-26🦠 microbiology

Reusable immobilised quaternary ammonium particles reduce microbial and resistome burdens without promoting resistance selection during wastewater post-treatment.

This study demonstrates that reusable, immobilized benzyldimethyldodecyl ammonium chloride (BDMDAC) particles effectively reduce microbial and resistome burdens in wastewater post-treatment through a contact-restricted mechanism that achieves high lethality without promoting resistance selection or horizontal gene transfer.

Redondo, M., Kluemper, U., Pereira, A. + 3 more2026-03-26🦠 microbiology

High-resolution temporal profiling reveals synchronized dynamics of the mouse gut microbiome

By developing an automated device for continuous fecal sampling and combining it with advanced sequencing, researchers revealed that the mouse gut microbiome exhibits synchronized, reproducible daily rhythms driven by carbohydrate utilization strategies that are temporarily disrupted by perturbations but subsequently recover.

Kurokawa, R., Maskawa, R., Arakawa, M. + 12 more2026-03-26🦠 microbiology

Insights into the Klebsiella pneumoniae adaptive response mechanisms to colistin exposure using a label-free quantitative proteomics approach

This study utilizes label-free quantitative proteomics to reveal that *Klebsiella pneumoniae* mounts a rapid, multifaceted adaptive response to colistin stress through outer membrane remodelling, lipid A modification, and metabolic re-routing, thereby identifying potential new therapeutic targets against multidrug resistance.

Dwibedy, S. K., Padhy, I., Pathak, S. K. + 1 more2026-03-26🦠 microbiology

Biofilm Initiation via Extracellular Matrix Production Driven by Cell Orientation Patterning in Growing Escherichia coli Populations

This study reveals that in growing *Escherichia coli* populations, the production of the biofilm matrix component colanic acid is spatially initiated at topological defects where cell orientation mismatches generate mechanical pressure, thereby demonstrating how cell orientation patterning organizes mechanical cues to trigger biofilm formation.

Yokoyama, F., Takeuchi, K. A.2026-03-26🦠 microbiology

Engineered phages evade the complete defense repertoire of highly phage-resistant MRSA clinical isolates

This study demonstrates that engineered phages, designed through defense-guided recombination to evade the complete repertoire of anti-phage systems in highly resistant MRSA clinical isolates, effectively prevent the emergence of bacterial resistance and offer a blueprint for rational next-generation phage therapeutics.

Voss, S. M., King, K. C., Hunt, D. J. + 6 more2026-03-26🦠 microbiology

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