838 papers
This study demonstrates that the clinical *Campylobacter jejuni* Bf strain utilizes selective secretion of larger, compositionally altered extracellular vesicles as a survival strategy to adapt to combined thermal and oxidative stress, thereby linking environmental resilience to enhanced epithelial toxicity and virulence.
This study elucidates the complex enzymatic pathway used by the gut symbiont *Bacteroides thetaiotaomicron* to degrade mucin O-glycans and demonstrates that multiple exo-acting enzymes targeting these structures are essential for successful gut colonization.
This study demonstrates that chemical induction of prophages in a *Sargassum*-derived biofilm triggers a shift in microbial community composition—specifically reducing *Vibrio* abundance while promoting other genera—and alters functional capacity by depleting key metabolic modules, highlighting prophage dynamics as a critical mechanism for structuring and adapting the *Sargassum* microbiome.
This study characterizes the genetic mechanisms of *Mycobacterium smegmatis* resistance to mycobacteriophage D29, revealing that a frequent synonymous mutation in MSMEG_4729 alone is insufficient for resistance but likely contributes to altered LOS biosynthesis and methyltransferase activity, while also identifying defense escape mutants that can overcome this resistance to inform the engineering of next-generation phage therapies.
This study reveals that certain mycobacteria utilize the type VII secretion system to weaponize endo-D-arabinanase toxins against the arabinogalactan cell walls of competing mycobacteria, a mechanism enabled by specific immunity proteins and widespread across the Mycobacteriales order.
This study presents pH-sensitive lipid nanocarriers composed of granulysin and oleic acid that protect the antimicrobial protein from degradation and release it specifically in acidic wound environments, effectively treating multidrug-resistant bacterial infections with minimal toxicity in both in vitro and murine models.
This study demonstrates the successful development and evaluation of a novel dual-target *Shigella sonnei* glycoconjugate vaccine, generated via in vivo bioconjugation using an oligosaccharyltransferase to link O-antigen with immunogenic carrier proteins, which effectively elicited IgG responses against both the carrier and the O-antigen in mice.
This study identifies and functionally validates specific cis-regulatory promoter motifs in the fungal pathogen *Ustilago maydis* that orchestrate the stage-specific temporal expression of effector genes during biotrophic infection.
Through experimental and mathematical modeling, this study suggests that O-antigen expression renders most enteric *Escherichia coli* resistant to co-occurring phages, thereby limiting the viruses' ability to shape bacterial strain composition in healthy human guts while maintaining phage populations through dynamic transitions between resistant and sensitive states.
This study reveals that corynephages encode a membrane protein called LysZ to overcome the mechanical rigidity provided by host membrane-anchored glycopolymers (LM/LAMs), which is essential for disrupting the mycomembrane and enabling successful host cell lysis and progeny release.