838 papers
The human Chk1 inhibitor CHIR-124 exhibits broad-spectrum antimalarial activity against various stages of *Plasmodium falciparum*, including drug-resistant strains, through a polypharmacological mechanism that simultaneously inhibits the essential kinase PfArk1 and disrupts hemozoin formation.
This study characterizes two novel thermotolerant *Leptolyngbya* cyanobacterial strains from Japanese hot springs and demonstrates through genomic and metagenomic analyses that they serve as food sources for sympatric tadpoles, offering insights into extreme environment ecology and potential biotechnological applications.
This study reveals that *Bordetella pertussis* exploits the host protein PGLYRP1 to exert a dual role in infection, where it initially enhances antibacterial defense via NOD1 signaling but later dampens inflammation and impairs bacterial killing by selectively suppressing TREM-1 and NOD2 pathways, thereby uncovering a novel immune evasion strategy with implications for vaccine and therapeutic design.
By integrating single-cell transcriptomics of *Toxoplasma gondii* from cat intestines with CRISPR-Cas9 Perturb-seq validation, this study constructs a comprehensive atlas of sexual development that identifies rare gamete populations and pinpoints AP2X6 as a key regulator of macrogametocyte differentiation.
This study identifies and characterizes two landfill-derived *Brucella intermedia* strains capable of biodegrading linear low-density polyethylene (LLDPE) through oxidative surface modification and biofilm formation, while confirming their low pathogenicity and limited antimicrobial resistance.
Genetic analysis of *Mycobacterium smegmatis* phages Girr and NormanBulbieJr reveals that efficient host lysis requires the coordinated function of two distinct holin-like proteins, LysF1a and LysF1b, where LysF1b is essential for preventing premature lysis and LysF1a acts as a regulatory partner rather than a pure antiholin.
This study elucidates the molecular mechanism by which the Yersinia pestis virulence factor YopM binds to the human pyrin death domain to inhibit inflammasome activation, revealing how this specific host-pathogen interaction likely drove the evolutionary selection of Familial Mediterranean Fever-associated mutations.
By establishing a stable laboratory husbandry system for greater horseshoe bats, researchers demonstrated that these animals coexist with SARS-CoV-2 through a unique host strategy involving a constitutive antiviral state, limited inflammation, and enhanced tissue repair, which allows for controlled viral replication without overt disease.
Elevation of β-hydroxybutyrate via 1,3-butanediol treatment suppresses intestinal Th17 responses and increases susceptibility to enteric infection by reshaping the gut microbiota to reduce segmented filamentous bacteria (SFB) abundance.
This study demonstrates that Matryoshka RNA virus 1 (MaRNAV-1) is a genuine intracellular virus infecting *Plasmodium vivax* across its lifecycle, where its presence correlates with enhanced parasite transmission potential and heightened host inflammatory responses.