794 papers
This study identifies FlhG, a MinD-like ATPase in *Borrelia burgdorferi*, as a spatial regulator that coordinates flagellar assembly with cell division by dynamically localizing to the poles and midcell to direct the positioning of key flagellar proteins, thereby ensuring the proper morphology and motility of spirochetes.
This study reveals that Enteropathogenic E. coli (EPEC) triggers coordinated, fast, and prolonged calcium responses in epithelial cells via low-level extracellular ATP and IP3 signaling, a mechanism that dampens NF-kappaB activation and modulates the host inflammatory response.
This study demonstrates that the innate immune protein calprotectin influences polymicrobial interactions between *Pseudomonas aeruginosa* and *Staphylococcus aureus* through a metal-independent mechanism where its protein scaffold modulates alkylquinolone production, thereby altering cell envelope gene expression and interspecies dynamics.
This paper addresses the challenges of genetic heterogeneity and incomplete segregation in *Synechocystis* PCC 6803 knock-out studies by developing standardized whole-genome sequencing workflows and proposing a practical guide to ensure robust, reproducible phenotypic characterization through routine strain validation and increased use of complementation controls.
This study demonstrates that the LMF1-IMC10-mediated contact site between the mitochondrion and inner membrane complex in *Toxoplasma gondii* is essential for maintaining proper mitochondrial morphology, regulating egress signaling via calcium homeostasis, and enabling the biosynthesis of critical cofactors like tetrahydrofolate and coenzyme A.
This study utilizes primary human keratinocyte differentiation models to demonstrate that while both VZV and HSV-1 replication are restricted in differentiated cells, VZV uniquely downregulates differentiation markers like K10 prior to replication, whereas HSV-1 requires full viral replication to achieve the same effect.
This study demonstrates that Oxford Nanopore long-read sequencing achieves comparable accuracy to Illumina short-read sequencing for *Mycobacterium tuberculosis* lineage assignment, antimicrobial resistance prediction, and outbreak detection, thereby validating the aggregation of data from both platforms for large-scale public health surveillance.
This study demonstrates that the first cysteine-rich motif of the Cryptococcus neoformans transcription factor Cuf1 is essential for sensing high copper stress and restricting the fungus to the lungs during infection, thereby playing a critical role in fungal virulence.
This study identifies HP1421, a hexameric VirB11-family ATPase encoded by a gene outside the *comB* operon, as an essential missing component (proposed as ComB11) of the *Helicobacter pylori* ComB type IV secretion system that is required for the uptake of transforming DNA into the periplasm during natural transformation.
This study demonstrates that Epstein-Barr Virus (EBV) exposure suppresses anti-tumor interferon production in human microglia while upregulating proto-oncogenic genes, revealing a potential mechanism by which EBV contributes to central nervous system malignancies in immunocompromised individuals.
This study presents the first complete genomes for the Actinomarinales order, revealing 9 species with a highly rearranged pangenome, a unique tRNA-bounded hypervariable region, extensive auxotrophies, and a widespread, previously unreported selenocysteine biosynthesis system that underscores the metabolic specialization of these abundant marine bacteria.
This study presents the largest collection of 135 complete *Pelagibacter* genomes to date, revealing 44 novel species, a universal hypervariable region driven by phage insertion, and phylogenetically structured metabolic auxotrophies, while demonstrating that standard metagenomic sequencing significantly underestimates the genus's true diversity.
This study demonstrates that applying complex, functionally diverse microbial consortia to lettuce and spinach significantly mitigates the negative impacts of 30% deficit irrigation by improving yield, accelerating harvest, and enhancing physiological resilience, thereby offering a scalable biological strategy to sustain agricultural productivity under water scarcity.
This study reveals that the anaerobic fungus *Caecomyces churrovis* produces hydrogen via a newly identified non-bifurcating NADH-dependent enzyme complex formed by [FeFe] hydrogenase and NADH dehydrogenase subunits, a mechanism distinct from the ferredoxin-dependent pathways previously assumed and likely shared across anaerobic fungi.
This study reports the molecular identification and characterization of diverse novel mobatvirus variants in four bat species and wet market animals in Lao PDR, revealing distinct phylogenetic lineages and highlighting a potential zoonotic risk at the human-wildlife interface.
This study reveals that in *Staphylococcus aureus*, the fatty acid synthesis (FASII) pathway acts as a critical checkpoint for lipoteichoic acid production by regulating intracellular glycerophosphate availability, thereby determining whether phosphatidylglycerol flux is directed toward essential LTA synthesis or alternative non-glycerophosphate lipids.
Using a cDNA-guided functional selection strategy in *Pseudomonas aeruginosa*, researchers identified novel defense systems against RNA phages, most notably characterizing Zws as a prevalent multidomain effector that utilizes an RNA endonuclease to selectively cleave viral genomes.
This study presents the first systematic metagenomic survey of Hawaiian geothermal fumaroles, revealing high viral diversity including two novel Caudoviricetes orders, evidence of viral-mediated microbial adaptation, and the first terrestrial occurrence of a Microviridae-dominated community, thereby challenging existing viral ecology models.
Defective HIV proviruses trigger chronic inflammation in people with HIV by producing aberrant intragenic RNAs from the *env* gene that activate the MDA5-MAVS innate immune pathway, leading to type I interferon responses in myeloid cells.
This study utilizes a high-throughput genetic screen to demonstrate that nutrient availability regulates *Staphylococcus aureus* extracellular vesicle production through the *agr* quorum sensing system, linking metabolic stress to vesiculogenesis.