797 papers
Under iron starvation, *Mycobacterium tuberculosis* overcomes metabolic stalling by partitioning the Krebs cycle into stalled oxidative and active reductive branches, diverting carbon flux to synthesize and secrete malate to maintain central carbon metabolism.
This study establishes a scalable genomic framework for programmable strain tagging in the diverse bacterial genus *Sphingomonas* by adapting CRISPR-associated transposons to target improved neutral sites and employing a novel rapid mapping method (tagIMseq) to validate precise insertions for high-throughput tracking of natural variation.
This study identifies the emerging carbapenem-resistant *Klebsiella pneumoniae* lineage CG307 as a distinct pathogen spreading across the Southern US that possesses unique genetic and phenotypic adaptations, including a novel capsule and high urease activity, which specifically drive its increased prevalence and virulence in urinary tract infections.
The study introduces LUCIA, a rapid cell-free screening platform that systematically validates AlphaFold-predicted protein interactions in herpesviruses, establishing an ipTM score threshold of 0.80 for high-confidence predictions and demonstrating the pipeline's utility by functionally characterizing a novel UL42-UL8 interaction essential for viral replication.
This study reveals that Type IV pilus length, governed by pilin abundance and extension dynamics rather than retraction force, critically determines bacterial virulence by regulating a hidden subpopulation of non-functional filaments and enabling adaptive bet-hedging across multiple pathogenic traits.
This study utilizes population-level whole-genome sequencing of *Mycobacterium tuberculosis* in non-human primates to reveal distinct intrahost mutational trajectories and increased bacterial diversification driven by SIV coinfection and antiretroviral therapy, highlighting specific selection pressures on lipid metabolism and oxidative damage response genes.
This study utilizes shotgun metagenomic sequencing of tracheal aspirate and stool samples from 39 preterm infants to demonstrate that an enrichment of skin-associated bacteria, particularly *Staphylococcus epidermidis*, in both the lung and gut microbiomes is significantly associated with the development of bronchopulmonary dysplasia.
This study elucidates how the essential *Acinetobacter baumannii* protein AdvA, which features a novel nucleotidyl-cyclase-like fold lacking canonical catalytic sites, orchestrates cell division by recruiting and activating divisome components, thereby offering a potential new target for antimicrobial strategies against this multidrug-resistant pathogen.
This study reveals that adults with Down syndrome exhibit specific gut microbiota alterations, including reduced *Roseburia* abundance, which are associated with cognitive decline and elevated plasma Alzheimer's disease biomarkers, suggesting a gut-brain axis link similar to that observed in typical Alzheimer's disease.
This study utilizes metagenomic analysis of *Apis cerana* honey from Vietnam's Northwest region to uncover a highly novel biosynthetic potential, identifying 366 gene clusters with over 83% lacking known database matches and highlighting a specific *Atlantibacter hermannii*-derived azole-containing RiPP cluster as a promising target for new antimicrobial discovery.
This study demonstrates that adaptive mutations in the *spoT* gene, which lower basal (p)ppGpp levels, enable *Ralstonia pseudosolanacearum* to efficiently adapt to both plant xylem and legume nodules by enhancing nutrient utilization and growth without compromising its virulence.
This study found that while roasted *Arachis hypogaea* (groundnut) diets showed slight, non-significant improvements in reducing parasite load and mitigating weight loss in *Plasmodium berghei*-infected mice, the overall dietary interventions failed to significantly restore haematological parameters or demonstrate substantial therapeutic value for malaria management.
By repurposing anti-phage defense systems BREX and DarTG to differentially arrest the ICP1 phage lifecycle, this study reveals that the parasitic satellite PLE utilizes a progressive licensing strategy dependent on multiple transcriptional milestones rather than genome replication to ensure robust activation.
This study utilized 16S rRNA gene sequencing to characterize and compare the bacterial community structures of compost-bedded pack barns on two dairy farms in Argentina, revealing that while both systems were dominated by typical compost-associated phyla, their specific community compositions differed based on distinct management practices and initial bedding conditions.
This study challenges the long-standing "one nucleus, one whole genome" paradigm by demonstrating that the model fungus *Neurospora crassa*, like certain pathogenic fungi, distributes its haploid chromosomes unevenly across multiple nuclei, suggesting this non-uniform genome partitioning may be a widespread evolutionary adaptation in fungi.
This study characterizes a novel Great Salt Lake methanogen, *Candidatus* Methanohalophilus hillemani, revealing that it maintains methane production under high salinity by prioritizing trace metal uptake and immune responses over traditional stress proteins, thereby confirming its active role in the lake's methane flux.
This study reports the draft genome sequence and taxonomic characterization of a novel soil bacterium, *Bacillus pergaminensis* sp. nov. strain Bva_UNVM-123, which possesses genetic determinants for heavy metal and antibiotic resistance, suggesting its potential as a safe candidate for bioremediation applications.
This study characterizes the physicochemical properties, sugar profiles, and mineral composition of *Meliponula beccarii* honey collected from the Wonchi district in Ethiopia, revealing high-quality attributes that support its traditional medicinal use and highlighting the region's potential for stingless bee conservation.
This study identifies human transferrin receptor 1 (hTfR) as a critical entry co-receptor that directly binds the Parvovirus B19 VP1u domain to mediate viral internalization and replication in erythroid progenitor cells, working in conjunction with the previously identified AXL attachment receptor.
This study reveals that *Pseudomonas aeruginosa* employs distinct immune evasion strategies depending on infection stage, utilizing reduced motility to minimize macrophage detection and engulfment during chronic infections while activating cytotoxicity to kill macrophages during acute infections.