228 papers
Neurology explores the intricate workings of the brain and nervous system, tackling everything from memory and movement to complex conditions like epilepsy and Alzheimer's. This field seeks to understand how our minds function and what happens when that delicate machinery falters, aiming to improve lives through better diagnosis and treatment.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category, offering both straightforward plain-language explanations and detailed technical summaries so you can grasp the science at your own pace. Below are the latest papers in neurology, ready for you to explore.
This study demonstrates that a fully automated 3D deep learning model achieves high accuracy and generalizability in segmenting meningiomas on multiparametric MRI, outperforming reference annotations in clinical plausibility while enabling rapid workflow integration.
The Project PAIR-PSP study presents the largest systematically profiled Indian cohort of 1,035 Progressive Supranuclear Palsy patients, revealing a diverse phenotypic distribution with a high frequency of non-Richardson's variants, distinct clinical trajectories across subtypes, and limited pharmacological response to levodopa.
This study identifies cerebrospinal fluid (CSF) TDP-43 as a promising novel biomarker for limbic-predominant age-related TDP-43 encephalopathy (LATE), demonstrating that its levels are disproportionately elevated in LATE patients compared to controls, ALS, and Alzheimer's disease, while remaining distinct from the typical Alzheimer's biomarker profile.
This study demonstrates that an affordable solar-powered photovoltaic-battery microgrid can reliably support the operation of an ultra-low-field portable MRI system in a rural Zimbabwean clinic, offering a viable blueprint for expanding diagnostic healthcare access in resource-limited settings.
This longitudinal study of older adults undergoing major surgery reveals that postoperative delirium and delayed resolution of interleukin-6 inflammation are significantly associated with one-year structural brain changes, specifically volume loss in the right hippocampus and putamen, as well as cortical thinning in the right superior parietal cortex.
This study demonstrates that a deep learning model can accurately synthesize clinically informative tau-PET scans from widely available MRI, blood biomarkers, and demographic data, offering a scalable and cost-effective alternative for estimating Alzheimer's disease tau pathology.
This study demonstrates that APOE isoforms differentially regulate astrocytic engulfment of synapses, with APOE4 promoting the highest phagocytic activity and the protective APOE3Ch variant failing to reduce this engulfment, suggesting that synapse phagocytosis is not the primary mechanism behind APOE3Ch's protective effect against Alzheimer's disease.
This protocol outlines a pre-post single-arm trial in Pakistan evaluating the effectiveness of an eight-week, digitally delivered multicomponent intervention on enhancing self-efficacy among primary caregivers of children with Spinal Muscular Atrophy and Duchenne Muscular Dystrophy.
This ENIGMA-Epilepsy study of over 2,000 individuals reveals that while epilepsy is associated with accelerated brain structural ageing, this effect is significantly exacerbated in countries with lower GDP per capita and higher income inequality, highlighting the critical influence of global socioeconomic context on neuroanatomical outcomes.
This study demonstrates that a single session of cortico-cortical paired associative stimulation (ccPAS) targeting the supplementary motor area and primary motor cortex significantly increases SMA-M1 facilitation in individuals with tremor-dominant Parkinson's disease, although this neurophysiological change did not translate into a reduction in tremor severity.