196 papers
This study of 79 epilepsy patients reveals that the seizure onset zone is characterized by a distinct connectivity pattern of being intrinsically hyperconnected internally while being extrinsically disconnected from the rest of the brain, a finding that reconciles prior inconsistencies and suggests improved methods for localizing the epileptogenic zone.
This study found that while central dopamine metabolism remains largely stable across SMA types and after Nusinersen treatment, lower baseline dopamine catabolite levels in the most severe SMA1 patients correlate with greater clinical impairment and reduced functional recovery, suggesting that reduced central dopaminergic turnover reflects disease progression.
This systematic review and meta-analysis of 32 studies involving 3,212 stroke survivors found that theory-based self-management interventions, particularly those grounded in self-efficacy theory, significantly improve self-efficacy and self-management behaviors, although the magnitude of the behavioral improvement is uncertain due to high heterogeneity among the diverse theoretical frameworks used.
This study demonstrates that functional neurological symptoms are common and often benign in healthy adults, suggesting that Functional Neurological Disorder (FND) should be redefined not by the mere occurrence of these symptoms, but by a failure in the mechanisms that normally allow them to resolve.
This study establishes that rare, dosage-sensitive variants in the OGA gene cause intellectual disability and motor impairments by disrupting neuronal maturation and circuit function, even in the absence of global O-GlcNAcylation perturbation.
Using natural language processing on brain imaging reports from a Scottish cohort of nearly 370,000 people, this study demonstrates that clinically reported covert cerebrovascular disease and cerebral atrophy are significant predictors of future stroke, dementia, and Parkinson's disease, highlighting the need for targeted prevention strategies.
This study found that while adults with new-onset epilepsy have a consistently higher risk of starting SSRI treatment compared to the general population, the shift toward newer antiseizure medications did not increase this likelihood, revealing a persistent and potentially widening treatment gap for depression, particularly among young adults.
This cross-sectional study of 3,174 female former soccer players found that higher cumulative exposure to repetitive head impacts was significantly associated with increased subjective cognitive complaints, behavioral dysregulation, and depressive symptoms, but showed no association with objective cognitive performance.
By recording from the motor cortex of human participants during rhythmic tapping tasks, this study reveals that rhythm and tempo are encoded through low-dimensional rotational neural dynamics that vary with tempo, are strengthened by tactile feedback, and are organized orthogonally to kinematic properties.
This systematic review and exploratory meta-analysis finds that while minocycline demonstrates promising biological activity and safety in acute traumatic spinal cord injury, current clinical evidence does not conclusively support its efficacy in improving neurological or functional outcomes, highlighting the need for further robust randomized controlled trials.
This randomized, double-blinded, crossover trial demonstrates that intermittent theta-burst transcranial temporal interference stimulation (iTBS-tTIS) targeting the right putamen significantly alleviates motor symptoms in Parkinson's disease patients, with therapeutic effects correlating to electric field strength in the targeted region, although no improvements were observed in motor learning tasks.
The paper introduces SPLASH, a benchtop-compatible ultrasensitive proximity ligation assay platform that enables cost-effective, decentralized quantification of key Alzheimer's disease plasma biomarkers using standard qPCR equipment, achieving performance comparable to specialized systems like Simoa while supporting dried sample collection.
This study employs a meta-analytic and unsupervised clustering approach to evaluate riluzole-based treatments for ALS, finding that while no adjunctive therapy significantly outperforms riluzole monotherapy, certain modulator classes show positive trends and highlighting a critical need for diverse, large-scale international trials due to current geographic research biases.
This study demonstrates that automated speech recognition (specifically Whisper), particularly when combined with quality control, offers a cost-effective and accurate alternative to manual transcription for characterizing linguistic impairments and classifying primary progressive aphasia variants, often outperforming manual methods in classification tasks.
In a large cohort of 3,245 patients with epilepsy, higher interictal spike rates on routine EEG were modestly associated with increased seizure frequency overall, with the strongest correlation observed in generalized and temporal lobe epilepsy subtypes, supporting the use of spike rate as a quantitative biomarker for seizure burden.
This cross-sectional study demonstrates that caregivers' descriptions of movement triggers and affected body regions differ significantly among children with cerebral palsy based on whether they have predominant dystonia, combined dystonia and spasticity, or spasticity alone, suggesting that these observations can help clinicians distinguish between the conditions to guide management.
This retrospective study demonstrates that while Progressive Muscular Atrophy (PMA) and Amyotrophic Lateral Sclerosis (ALS) share similar widespread cerebral hypometabolism on 18F-FDG-PET, Primary Lateral Sclerosis (PLS) exhibits a distinct, more focal pattern of motor cortical hypometabolism.
The ATTRACTION trial is a multicenter, prospective, double-blind, randomized study designed to evaluate the safety and efficacy of adjunct tirofiban therapy versus placebo in improving 90-day functional outcomes for patients with anterior circulation large vessel occlusion strokes who achieve successful recanalization following endovascular thrombectomy.
This retrospective study of 1,039 ischemic stroke patients reveals that poor brain health at the time of stroke leads to significantly worse 90-day functional outcomes for women compared to men, highlighting a critical sex-specific vulnerability in post-stroke recovery.
This study identifies a common human IL-34 loss-of-function variant (Y213X) that significantly reduces IL-34 levels, disrupts microglial homeostasis and network organization, and exacerbates amyloid pathology, thereby establishing IL-34/CSF1R signaling as a critical determinant of microglial resilience in Alzheimer's disease.