959 papers
The pan-CDK inhibitor CGP-60474 attenuates chronic kidney disease in mice by suppressing myeloid-driven inflammation and restoring tubular metabolic function, thereby reducing injury, fibrosis, and systemic inflammation.
This study demonstrates that a cocoa milk beverage fortified with lactulose and stevia, thickened with 0.10% carrageenan and maltodextrin, successfully achieves the required rheological properties for dysphagia management (IDDSI Levels 0–2) while maintaining temperature stability, shelf-life safety, and high sensory acceptance.
This study reports the first identification of *Neocosmospora falciformis*, *Fusarium nirenbergiae*, and *Fusarium* sp. 1 as the causal agents of root and stem rot in Komatsuna (*Brassica rapa* var. *perviridis*) in Tokyo, Japan, based on morphological, molecular, and pathogenicity evidence collected between 2021 and 2023.
This paper proposes a semantic-constrained, multi-stage digital restoration framework for traditional silk paintings that prioritizes the protection of cultural heritage elements by integrating interpretable damage detection, context-aware restoration routing, and quality-gated rollback mechanisms to balance effective damage removal with the preservation of historical evidence and material texture.
This study presents a ROS-responsive core-shell microneedle patch that enables minimally invasive, spatiotemporally sequential epicardial co-delivery of black phosphorus nanosheets and bufalin to simultaneously scavenge reactive oxygen species and suppress fibrosis, thereby effectively mitigating cardiac remodeling and restoring function in a murine myocardial infarction model.
This study demonstrates that 14-3-3γ is upregulated as a protective endogenous response to CoCl₂-induced hypoxia-like stress in SH-SY5Y cells, where its knockdown exacerbates neuronal injury by intensifying oxidative stress and apoptosis.
This study demonstrates that prolonged static aging at elevated temperatures (100–150°C) induces irreversible interfacial degradation and structural reorganization in olefin-based inverse emulsion drilling fluids, leading to significant changes in rheology, emulsion stability, and filtration performance that challenge current fluid integrity management practices in deepwater operations.
This empirical study of Bangladeshi university students reveals that dental appearance-related social confidence is primarily driven by self-perception and perceived social evaluation—specifically tooth discoloration, misalignment, and social media comparison—rather than socio-demographic factors, often resulting in a state of "uncomfortable confidence" where students maintain social interactions despite self-consciousness.
This study overturns the classical model of paternal chromatin remodeling by demonstrating that spermatid chromatin compaction follows a programmed, pre-meiotic 3D-architecture template involving a direct histone-to-protamine-1 transition, rather than relying on the sequential replacement by transition proteins.
The paper reveals that financial markets are pricing in significantly higher oil reserve values than climate mitigation scenarios allow, creating a $46.2 trillion valuation gap by 2034 concentrated in state-owned entities of six nations, which poses a severe risk of sovereign debt crises if oil-dependent economies fail to diversify.