1582 papers
This study demonstrates that 4-Methylumbelliferone (4MU) exerts antitumor effects in glioblastoma cells by inducing early oxidative stress that depletes NAD⁺, disrupts N-glycosylation, and triggers compensatory metabolic rewiring, thereby revealing a novel mechanism for targeting metabolic vulnerabilities in this aggressive brain tumor.
This study demonstrates that two massive coral species in a remote southwestern Gulf of Mexico reef system exhibited sustained molecular stress responses, indicated by progressively elevated HSP70 expression, during the extreme 2023–2025 marine heatwaves, revealing species-specific physiological strategies and the approach of thermotolerant corals to their functional limits under recurring thermal stress.
This study demonstrates that listening to emotion-matched music during self-paced cycling increases heart rate and positive affect without raising perceived exertion, effectively decoupling physiological engagement from the sensation of effort.
This study demonstrates that a semi-automated pipeline using clinical CT scans and OTOPLAN segmentation can achieve moderate accuracy (79%) in sex estimation by analyzing cochlear shape descriptors, offering a non-destructive and scalable alternative for forensic anthropology when traditional skeletal methods are unavailable.
This study demonstrates that a phantomless air-fat-muscle calibration method is a reproducible and promising alternative to phantom-based calibration for predicting metastasised femoral strength using both linear and non-linear finite element models, with the linear Lyon model showing greater robustness to calibration differences.
This study demonstrates that the aqueous seed extract of *Dennettia tripetala* significantly protects female Wistar rats from Bisphenol A-induced ovarian oxidative stress, hormonal disruption, and microbial burden in a dose-dependent manner, with the 800 mg/kg dose showing efficacy comparable to Vitamin C.
This study analyzes genomic data from over 11,000 *Mycobacterium tuberculosis* Lineage 2 isolates to reveal that their global transmission and multidrug resistance are driven not by single high-effect mutations, but by the combined influence of multiple moderate-effect variants affecting drug resistance, cell-envelope functions, lipid metabolism, and parallel evolution.
This study demonstrates that the accuracy of deconvolving overlapping event-related potentials using general linear modeling is critically dependent on the complex interactions between experimental design factors (temporal jitter and sequential correlation) and analytical parameters (modeling window length and regularization), which can be unified and predicted through multicollinearity analysis to guide optimal experimental planning.
This study identifies the tonoplast-localized transporter ENT1 in *Arabidopsis thaliana* as a critical gatekeeper of intracellular cytokinin riboside availability that regulates hormone homeostasis and is essential for enabling beneficial microbe-induced plant defense against pathogens.
The study reveals that the GluN1-Met641Ile NMDA receptor variant reduces calcium permeability by inducing a largely calcium-impermeable subconductance state through enhanced interactions between the Ile641 side chain and the M2 pore loop.