🧬 Category

q-bio

1582 papers

🧬 biology

LncRNA BCYRN1 regulates mitochondrial MT-ND1/4/5 transcription via heavy strand promoter methylation to promote oxidative phosphorylation and proliferation in acute myeloid leukemia

This study reveals that the mitochondria-localized lncRNA BCYRN1 promotes acute myeloid leukemia progression by epigenetically activating the transcription of MT-ND1/4/5 via heavy strand promoter methylation to enhance oxidative phosphorylation, identifying both the lncRNA and the mitochondrial RNA polymerase inhibitor IMT1B as promising therapeutic targets.

Ye Kuang, Jia Wang, Jing Li, Chuanmei Peng, Yong Ji, Jinrong Tian, Sulian Chen, Shiyan Nian, Lei Feng2026-07-07
🧬 biology

Single-cell and spatial transcriptomic profiling of primary versus recurrent glioblastoma identifies PLOD2 as a core orchestrator of hypoxic niche remodeling and mesenchymal transition

This study integrates multi-omics profiling to identify PLOD2 as a critical driver of glioblastoma recurrence that orchestrates hypoxic niche remodeling and mesenchymal transition via a PLOD2/LAMA4 axis, thereby promoting treatment resistance and offering a potential therapeutic target.

Zhong Wang, Fei Wang, Wenqian Cao, yuhan Bai, Yining Zhang, Chen Yang, Run Huang, Haohao Qiu, Yanbo Yang, Juyi Zhang, Yo (…)2026-07-07
🧬 biology

Genome-wide characterization of Plasmodium vivax infections in local travelers and non-travelers from the Peruvian Amazon

This study utilizes whole-genome sequencing to demonstrate that while *Plasmodium vivax* infections in travelers within the Peruvian Amazon exhibit higher genetic diversity and heterogeneity, they largely remain genetically connected to local non-traveler populations, thereby supporting the integration of genomic and epidemiological data to distinguish imported from locally acquired malaria transmission.

Mahdi Safarpour, Luis Cabrera-Sosa, Johanna H. Kattenberg, Ramses Deyaert, Anna Rosanas-Urgell, Joseph M. Vinetz, Jean-P (…)2026-07-07
🧬 biology

The chromosome-level genome of Elsholtzia splendens provides insights into genome evolution and environmental adaptation

This study presents a chromosome-level genome assembly of the copper-hyperaccumulating plant *Elsholtzia splendens*, revealing how transposon bursts, gene family expansions, and specific Heavy Metal ATPase networks collectively drive its extreme copper tolerance and offering valuable genetic targets for soil phytoremediation.

Licao Cui, Yiting Su, Han Lin, Xiaofeng Yang, Yu Lu, Yuzhe Song, Yihan Li, Qinglin Ke, Ruimin Li2026-07-07
🧬 biology

Concentration-Dependent Membrane Interactions and Pore Stability of Aurein 1.2 and LLAA Revealed by Coarse-Grained Molecular Dynamics Simulations

Coarse-grained molecular dynamics simulations reveal that the aurein 1.2 analogue LLAA exhibits stronger membrane insertion and deeper interaction with bacterial membranes compared to the native peptide, yet forms less stable pores that disassemble rapidly, whereas aurein 1.2 maintains long-lived pore stability, highlighting how subtle sequence and charge differences dictate membrane interaction mechanisms and pore dynamics.

Roshanak Ansarihaghi2026-07-07
🧬 biology

Metabolic profiling of retinal organoids reveals conserved core metabolites and alterations in glycolytic, and amino acid pathways

This study utilizes untargeted GC-MS metabolomic profiling to demonstrate that while mouse retinal organoids preserve a conserved core metabolic signature of the native retina, they exhibit specific alterations in glycolytic, amino acid, and TCA cycle pathways that suggest incomplete metabolic maturation.

Pragati Gupta, Claudia Wiesner, Focke Zimmsen, Jeroen Klevering, Purva Kulkarini, Zohreh Hosseinzadeh2026-07-07
🧬 biology

Mold Fungi Syncephalastrum contaminatum STG-160 and Cladosporium sphaerospermum STG-161 from 16 th century icon—Risks of Tempera Pigments Degradation

This study characterizes the heavy metal tolerance and siderophore-producing capabilities of two mold fungi isolated from a 16th-century Russian icon to identify specific tempera pigment areas vulnerable to degradation, thereby guiding targeted biocide treatments for the artwork's preservation.

Daria Avdanina, Anna Ermolyuk, Egor Troyan2026-07-07
🧬 biology

A fibroblast–myeloid niche supports stress adapted residual oesophageal adenocarcinoma after neoadjuvant chemotherapy

This study utilizes integrated single-cell and spatial transcriptomics to reveal that residual oesophageal adenocarcinoma cells surviving neoadjuvant chemotherapy are supported by a specific fibroblast–myeloid niche, highlighting that treatment resistance arises from both malignant cell plasticity and microenvironmental protection.

Samuel Hill, Ian Reddin, Christina Putnam, Rushda Rajak, Sonya James, Jeanette Norman, Robert Walker, Jack Harrington, M (…)2026-07-07
🧬 biology

Babesia capensis sp. nov. – Description of a Babesia species causing disease in domestic cats from South Africa

This study formally describes and names *Babesia capensis* sp. nov., a novel large-form piroplasm causing disease in domestic cats in South Africa, based on its distinct morphological, genetic, and phylogenetic characteristics, while also noting its association with caracals and its responsiveness to diminazene aceturate treatment.

Gad Baneth, Marinda C. Oosthuizen, Aletta Mulder, Yaarit Nachum-Biala, S. Marcus Makgabo, Ilse Vorster, Jacqueline Bisho (…)2026-07-07