1582 papers
This study demonstrates that while mild perceived fatigue during repeated sit-to-stand movements preserves the spatial structure of muscle synergies, it induces selective timing adjustments in specific synergies that are closely linked to compensatory changes in center of mass control.
This study demonstrates that under hypoxic conditions, Golgi protein 73 (GP73) drives hepatocellular carcinoma progression by promoting the Warburg effect and epithelial-mesenchymal transition through the stabilization of HIF-1α, identifying the GP73–HIF-1α axis as a critical mediator of TACE resistance and a potential therapeutic target.
This study utilizes BAC-based physical mapping and targeted sequencing to resolve the fragmented architecture of the giant panda immunoglobulin light chain loci, providing a complete germline genomic characterization of 22 κ and 187 λ variable genes that establishes a critical foundation for immune repertoire analysis and species conservation.
This study reveals that orangutan alarm calls are assembled by a hidden generative rule producing complex, long-range dependent structures from eight call types, suggesting that key precursors to human vocal generativity existed in ancestral hominids.
This study reveals that the inactivation of the cervical cancer marker ZNF582 leads to the derepression of HERVH, which sequesters the NF-κB repressor NKRF to unleash NF-κB signaling and drive tumor progression, thereby identifying a ZNF582–HERVH–NKRF–NF-κB axis as a potential therapeutic target for cervical cancer.
This study demonstrates that lead acetate negatively impacts the adaptive responses of diverse organisms, including ciliates, fish, and rodents, across various levels of the trophic pyramid and phylogenetic development.
This study demonstrates that incorporating realistic dispersal behaviors, particularly cross-diffusion, into mutualistic meta-network models reveals that dispersal significantly destabilizes homogeneous steady states, thereby reversing previously reported positive relationships between stability and species richness while establishing a unimodal relationship with connectance.
This paper introduces GREAC, an open-source, alignment-free software tool that utilizes k-mer-based dimensionality reduction to extract discriminative genomic regions for accurate, explainable, and reference-independent classification of viral variants and evolutionary patterns.
This study demonstrates that both visual and chemical cues significantly influence the nest- and bower-building behaviors of *Coptodon rendalli* and *Oreochromis shiranus*, with optimal structure dimensions observed when males and females are separated by a fine net and when water contains specific levels of soil substrate-treated cues, providing valuable insights for improving hatchery breeding conditions.
This study challenges the "tumor-as-gonad" dogma by demonstrating that castration-resistant prostate cancer relies on converting adrenal steroid precursors rather than autonomous de novo synthesis, revealing a metabolic and lineage plasticity spectrum that dictates androgen receptor signaling and survival risk.