q-bio papers | Gist.Science

Platelet-Rich and Platelet-Poor Plasma Treatment Pre- and Post-Breeding 2 Differentially Regulates Gene Expression in Early Equine Embryos from Mares 3 Susceptible to Persistent Breeding-Induced Endometritis

This study demonstrates that intrauterine infusion of platelet-rich plasma (PRP) or platelet-poor plasma (PPP) in mares susceptible to persistent breeding-induced endometritis differentially modulates early embryonic gene expression, with PRP enhancing cellular homeostasis and PPP promoting developmental regulation and energy metabolism, indicating that these therapies influence the embryonic transcriptome via endometrial effects independent of platelet concentration.

Mariana P. Mazzuchini, Alejandro Fuente, Lorenzo GTM Segabinazzi, Jamie K. Norris, Marco A Alvarenga, Pouya Dini, Igor F (…)2026-09-01

🧬 biology

Characterizing ecological sieves in urban green spaces: PCA analysis of habitat gradients and avian species-specific occupancy regressions

This study of 57 parks in arid Isfahan, Iran, demonstrates that avian biodiversity is primarily shaped by structurally complex, high-density canopy networks rather than park size or human disturbance alone, with species-specific occupancy responses varying significantly across distinct habitat gradients.

Maryam Razazzadeh, Ali Lotfi, Ali Asgarian, Sima Fakheran2026-09-01

🧬 biology

Global research trends in male fertility and environmental factors (2016-2025)： a multi-database bibliometric analysis and cross-validation study

This multi-database bibliometric analysis of global research from 2016 to 2025 reveals a rapidly expanding, interdisciplinary field centered on oxidative stress and environmental factors affecting male fertility, with China and the US as leading contributors and future directions pointing toward epigenetic mechanisms, emerging pollutants, and biomarker development.

Chao Du, Lisha Chen, Xinyue Fan, Ao Li, Yuexin Yu2026-09-01

🧬 biology

10-HDA from royal jelly ameliorates autism-like behaviors by promoting Treg commitment through microbiota-IL-6-driven bivalent histone remodeling

This study demonstrates that 10-HDA, a key component of royal jelly, ameliorates autism-like behaviors in mice by restructuring the gut microbiota to suppress IL-6, which subsequently downregulates the methylase Kmt2b to remodel bivalent histone landscapes and promote the epigenetic commitment of Tregs, thereby restoring immune balance and social function.

Yi Xu, Feng Zhu, Ruili Yang, Biao He, Ying Zhang, Jie Zhang, Yuxuan Zhi, Jianan Li, Hui-Li Wang2026-09-01

🧬 biology

Outcome of low pathogenicity avian influenza (H7N9) experimental infection of urban and rural house sparrows (Passer domesticus) is impacted by natural Avipoxvirus infection

This study demonstrates that urban and rural house sparrows are similarly susceptible to low pathogenicity H7N9 avian influenza, but natural co-infection with Avipoxvirus significantly increases the prevalence and persistence of both viruses, highlighting a critical ecological interaction that may influence the birds' role as bridge hosts for influenza transmission.

Sara Minayo-Martín, Alberto Sánchez-Cano, Rosa Valle, María J. Valdez-May, Richard A.J. Williams, Kateri Bertran, Natàli (…)2026-09-01

🧬 biology

Carried but Conditionally Used: A Frozen Held-Out Audit of Whether Chirality-Aware Molecular Fingerprints Predict Measured Same-Assay Enantioselectivity

This study employs a prospectively specified, cryptographically frozen audit to demonstrate that while radius-3 Morgan fingerprints effectively distinguish enantiomers, their ability to predict measured same-assay enantioselectivity under scaffold extrapolation is real but strongly target-dependent, yielding significant results for only a subset of targets while others show null or negative predictive skill.

Dylan Ashraf2026-09-01

🧬 biology

Validation design changes wearable stress-state classification performance in hospital nurses

This study demonstrates that while wearable-based stress classifiers for hospital nurses may show high internal accuracy, their performance significantly degrades when evaluated on unseen individuals, highlighting the critical need for participant-level validation to ensure transportability before operational use.

Fuat Kahraman, Gözde Özsezer, Gülengül Mermer2026-09-01

🧬 biology

Multi-omics integrative analysis reveals shared immunometabolic features between breast cancer and type 2 diabetes through CLEC7A associated myeloid immune reprogramming and the MIF signaling axis

This multi-omics study reveals that breast cancer and type 2 diabetes share immunometabolic mechanisms driven by CLEC7A-associated myeloid immune reprogramming and the MIF–CD74/CXCR4 signaling axis, offering new insights into their cross-disease inflammatory communication and potential therapeutic targets.

Jia Li, Chundi Gao, Minghui Wu, Yanyan Pan, Xiaoming Zhang, Changgang Sun2026-09-01

🧬 biology

Whole chickpea suppresses colorectal cancer progression through gut microbiome and metabolome modulation

This study demonstrates that dietary supplementation with whole chickpeas suppresses colorectal cancer progression in mice by modulating the gut microbiome and metabolome, specifically through the enrichment of beneficial bacteria and the upregulation of protective metabolites like 13(S)-HpODE and dihydroresveratrol.

Yiming Qin, Tianrui Gao, Ziqi Liu, Yingxin Zhou, Yingying Zhou, Mingyue Song, Xuebo Liu, Guidong Huang, Lile Shi, Quanca (…)2026-09-01

🧬 biology

The dynamical advantage of scale-free networks

This paper reveals that while degree heterogeneity in scale-free networks hinders control toward arbitrary states, it actually facilitates control toward natural attractors, thereby acting as a dynamical design principle that balances structural robustness with selective functional responsiveness.

Huijun Gao, Yimeng Qi, Songlin Zhuang, Zhihong Zhao, Xiaotian Lin, Xinghu Yu, Weichao Sun, Fangzhou Liu, Charo I. del Ge (…)2026-09-01

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