q-bio papers | Gist.Science

Using stable isotopes to reveal site-level differences in juvenile lemon shark Negaprion brevirostris (Carcharhiniformes: Carcharhinidae) nursery habitat use in the British Virgin Islands

This study utilizes stable isotope analysis of juvenile lemon sharks and their prey in the British Virgin Islands to demonstrate that two nearby nursery sites operate on distinct nutrient regimes and seagrass-based carbon pathways, providing a quantitative baseline for monitoring future environmental changes.

Bryan Legare, Agnes Mittermayr, Kendyl Bernā, Abbi E. Christopher, Gregory B. Skomal, Andy J. Danylchuk, Chris Juredin2026-09-01

🧬 biology

MRI Evidence of Anterograde Trans-synaptic Degeneration After Eye Loss: Preserved Primary Visual Cortex Thickness Despite Lateral Geniculate Nucleus Atrophy

This study demonstrates that while eye loss leads to significant bilateral atrophy of the lateral geniculate nucleus, the primary visual cortex maintains its cortical thickness, indicating a differential susceptibility of subcortical and cortical visual structures to anterograde trans-synaptic degeneration.

David Llanos, Enrique Santos, Federico Saenz-Frances, Íñigo de la Pedraja, Juan Arrazola2026-09-01

🧬 biology

The glycemic variability induces ovarian dysfunction in NOD mice by inducing ferroptosis

This study demonstrates that glycemic variability, specifically recurrent hypoglycemia, induces ovarian dysfunction in NOD mice and human granulosa cells by triggering ferroptosis through oxidative stress and lipid metabolism disruption, rather than classical apoptosis.

Jiayu Huang, An He, Ying Chen, Yin Tian, Xinmiao Tan, Yingyu Tian, Hanke Zhang, Jiying Hou, Shimeng Guo2026-09-01

🧬 biology

Beyond insects: leveraging bulk arthropod samples for vertebrate biodiversity monitoring using invertebrate-derived DNA (iDNA) metabarcoding

This study demonstrates that invertebrate-derived DNA (iDNA) metabarcoding of bulk arthropod samples collected via malaise traps can effectively complement camera trap surveys for monitoring forest vertebrate biodiversity, successfully detecting a range of native, pest, and domesticated species with high congruence for common and cryptic fauna.

Laurence Dugal, Natasha Harrison, Rebekah Hortin, Kiara DeLandgrafft, Kristen Fernandes2026-09-01

🧬 biology

Gut microbiota-derived metabolites in prostate cancer: a network pharmacology-based identification

This study utilizes network pharmacology to identify 34 core targets and key gut microbiota-derived metabolites, such as quercetin and indole-3-lactic acid, that may regulate prostate cancer progression primarily through the PI3K-AKT and MAPK signaling pathways.

Yudian Wang, Ling Chen2026-09-01

🧬 biology

In silico genome mining of biosynthetic gene clusters in the marine actinobacteria Salinispora and identification of novel secondary metabolites

This study employs a deep learning framework called DeepBGC to uncover 138 hidden biosynthetic gene clusters across eight *Salinispora* species, identifying 52 novel orphan clusters that encode 184 structurally unique metabolites with promising bioactivities for future natural product discovery.

Sibashsis Sarangi, Satya Ranjan Dash, Rajani Kanta Mahapatra2026-09-01

🧬 biology

Anti-Candida properties of 5-butyl-2-pyridine carboxylic acid, extracted from azole drug-sensitive microfungi Aspergillus fumigatus nHF-01

This study demonstrates that 5-butyl-2-pyridine carboxylic acid, extracted from *Aspergillus fumigatus*, exhibits potent anti-*Candida* activity by disrupting cell integrity, inhibiting biofilms, synergizing with conventional antifungals, and likely targeting the ergosterol biosynthesis enzyme CYP51.

Vivekananda Mandal, Rajsekhar Adhikary, Narendra Nath Ghosh, Sayan Poddar, VIVEKANANDA MANDAL2026-09-01

🧬 biology

Cross-Trait Integration of Fine-Mapped Signals From 30 Brain-Related Genome-Wide Association Studies Prioritizes DRD2 as a Pleiotropic Network Hub

By applying a novel three-level framework to integrate fine-mapped signals from 30 brain-related GWAS datasets, this study identifies DRD2 as a central pleiotropic network hub influencing diverse psychiatric, cognitive, and behavioral phenotypes.

Kenneth Blum, Alireza Sharafshah, Kai-Uwe Lewandrowski, Morgan P. Lorio, Panayotis K. Thanos, Rafael Rea, Edward J. Mode (…)2026-09-01

🧬 biology

Activation of Trpv2 receptors increases the intravenous self-administration of low unit doses of cocaine in C3HeB/FeJ mice

This study demonstrates that activating Trpv2 receptors increases the intravenous self-administration of low-dose cocaine in C3HeB/FeJ mice in a sex-dependent manner, suggesting that Trpv2 function is modulated by genetic background, cocaine dose, and sex, and warrants further investigation as a therapeutic target for substance use disorders.

Devon T. Applegate, Thomas R. Rahr, James David Jentsch2026-09-01

🧬 biology

The green menace: non-native green seaweed detected in Western Antarctica using molecular tools

By combining specimen DNA barcoding and environmental DNA metabarcoding, this study establishes a molecular baseline for green seaweeds in Western Antarctica, revealing a potentially endemic *Ulva* lineage while simultaneously detecting cosmopolitan non-native lineages transported via shipping and rafting, thereby highlighting the region's growing vulnerability to biological invasions.

Hélène Dubrasquet, Zambra López-Farrán, Lilibeth Vasquez, Inès de la Brosse, Line Le Gall, Wendy Nelson, Catriona Hurd (…)2026-09-01

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