3882 papers
This study demonstrates that invertebrate-derived DNA (iDNA) metabarcoding of bulk arthropod samples collected via malaise traps can effectively complement camera trap surveys for monitoring forest vertebrate biodiversity, successfully detecting a range of native, pest, and domesticated species with high congruence for common and cryptic fauna.
This study utilizes network pharmacology to identify 34 core targets and key gut microbiota-derived metabolites, such as quercetin and indole-3-lactic acid, that may regulate prostate cancer progression primarily through the PI3K-AKT and MAPK signaling pathways.
This study employs a deep learning framework called DeepBGC to uncover 138 hidden biosynthetic gene clusters across eight *Salinispora* species, identifying 52 novel orphan clusters that encode 184 structurally unique metabolites with promising bioactivities for future natural product discovery.
This study demonstrates that 5-butyl-2-pyridine carboxylic acid, extracted from *Aspergillus fumigatus*, exhibits potent anti-*Candida* activity by disrupting cell integrity, inhibiting biofilms, synergizing with conventional antifungals, and likely targeting the ergosterol biosynthesis enzyme CYP51.
By applying a novel three-level framework to integrate fine-mapped signals from 30 brain-related GWAS datasets, this study identifies DRD2 as a central pleiotropic network hub influencing diverse psychiatric, cognitive, and behavioral phenotypes.
This study demonstrates that activating Trpv2 receptors increases the intravenous self-administration of low-dose cocaine in C3HeB/FeJ mice in a sex-dependent manner, suggesting that Trpv2 function is modulated by genetic background, cocaine dose, and sex, and warrants further investigation as a therapeutic target for substance use disorders.
By combining specimen DNA barcoding and environmental DNA metabarcoding, this study establishes a molecular baseline for green seaweeds in Western Antarctica, revealing a potentially endemic *Ulva* lineage while simultaneously detecting cosmopolitan non-native lineages transported via shipping and rafting, thereby highlighting the region's growing vulnerability to biological invasions.
This metaproteomic study of 48 children with Down syndrome reveals that gut comorbidities are associated with a hypofunctional, short-chain fatty acid-poor microbiota characterized by specific pathway down-regulations, while the host fecal proteome reflects T21-related immune and matrix remodeling processes, offering new insights for therapeutic interventions.
This study identifies matricytosis as a phenotype-specific extracellular matrix internalization program that is dysregulated in pulmonary fibrosis, characterized by impaired uptake in disease-associated macrophages and enhanced, invasion-linked uptake in myofibroblasts, ultimately revealing cell-type-specific mechanisms and therapeutic targets for ECM clearance.
This study reveals that while the repertoire of biosynthetic gene cluster classes is conserved across Brazilian *Lactiplantibacillus plantarum* genomes, significant structural diversification occurs within homologous clusters, particularly in terpene and T3PKS pathways, highlighting internal variation as the primary driver of biosynthetic diversity in these strains.