3881 papers
This study demonstrates that ARID2 deficiency in melanoma creates a context-specific vulnerability to the synergistic effects of combined EGFR/HER2 and BET inhibition, a therapeutic strategy that is more effectively revealed through 3D spheroid models than traditional 2D cultures.
This study integrates multi-omics data to define a conserved 41-gene signature in idiopathic pulmonary fibrosis that reveals a pathogenic cascade driven by alveolar type 1 cell dysfunction, leading to KRT17+ aberrant basaloid repair and fibroblast activation, while identifying potential therapeutic targets for drug repurposing.
This study utilizes MaxEnt modeling to map the potential high-resolution distribution of the taiga tick (*Ixodes persulcatus*) in Mongolia, identifying northern, central, and northeastern regions as areas of highest climatic suitability to inform targeted surveillance and disease prevention strategies.
This study developed a robust machine learning-based T-cell-associated signature that outperforms conventional clinical traits in predicting breast cancer prognosis and identifying patients likely to benefit from immunotherapy.
This study demonstrates that acemannan, a polysaccharide derived from *Aloe vera*, exhibits significant synergistic effects with conventional antibiotics against multidrug-resistant ESKAPE pathogens by enhancing biofilm inhibition and bactericidal activity, particularly against Gram-positive strains, through favorable molecular interactions with key bacterial protein targets.
This study analyzes 507 lactic acid bacteria genomes to reveal a highly conserved core genomic architecture for fermentation functions, while highlighting that lineage-specific metabolic diversification primarily occurs in pyruvate routing and lactate formation pathways.
Using Xenium-based spatial transcriptomics, this study comprehensively maps the lung cancer ecosystem in both murine and human tissues, revealing distinct spatial domains and cellular neighborhoods that define unique peri-tumoral and intra-tumoral microenvironments with specific implications for tumor evolution and therapeutic response.
This study establishes a baseline for Caribbean reef-building coral conservation by analyzing thousands of *Acropora* and *Orbicella* genets to reveal that while pure species lineages dominate, naturally occurring hybrids are widespread and common, challenging the assumption that restoration efforts should focus exclusively on pure species.
This study identifies a novel broad-spectrum powdery mildew resistance gene, *PmXP544*, from wild emmer wheat accession CWI47098, localizes it to a 2.1 Mb region on chromosome 4AL, and elucidates its underlying defense mechanisms through integrated genetic and transcriptomic analyses to facilitate marker-assisted breeding.
This study demonstrates that hypoxia-induced RBM47, which is upregulated by HIF1α and transferred via exosomes, promotes glioblastoma invasiveness by driving the alternative splicing of fibronectin 1 (FN1) toward the pro-invasive EDB+ isoform.