🧬 Category

q-bio

1584 papers

🧬 biology

Evolutionary dynamics and genomic diversification of the mcr-9.1 region in Cronobacter sakazakii across four decades

This study reconstructs the 43-year evolutionary history of the mcr-9.1 region in *Cronobacter sakazakii*, revealing a conserved core structure that has evolved into a complex, semi-mobile genomic module predominantly associated with the chromosome in early isolates but increasingly linked to plasmids in recent years through clonal expansion and horizontal gene transfer.

Shafaa Shawqi Ali2026-07-07✓ Author reviewed ⓘ
🧬 biology

Source- and Release-Aware Calibration Recovers EGFR Potency Prediction Under Cross-Source and Future-Release Domain Shift

This paper demonstrates that while standard EGFR potency models suffer severe performance degradation under cross-source and future-release domain shifts, their predictive accuracy can be effectively recovered through a lightweight, source- and release-aware residual calibration strategy using a small set of scaffold-disjoint support labels.

Nhat Trinh Ngoc Minh, Kien Pham Xuan, Vinh Truong Hoang, Hien Nguyen Thanh, Linh Nguyen Thi My2026-07-07
🧬 biology

Immune Cell Heterogeneity in Multiple Sclerosis Reveals Myeloid-Specific Dysfunction and Distinct Regulatory Programs Across CD14+, CD4+, and CD8+ Immune Cells

This study utilizes integrated systems biology analysis of bulk RNA-seq data to demonstrate that while Multiple Sclerosis involves immune heterogeneity across CD14+, CD4+, and CD8+ cells, CD14+ myeloid cells exhibit the most profound transcriptional and regulatory dysfunction characterized by pro-inflammatory, metabolic, Wnt, and calcium signaling abnormalities, highlighting them as a central driver of MS immunopathology.

Ali Salari, Mahdi Yazdani, Marzieh Sharifi Pasandi, Masih Akbari, Parsa Saadati, Abolfazl Sahabjo, Mohammad Hosein Shahs (…)2026-07-07
🧬 biology

Peripheral PDCD4 Expression Links to T-Cell Immune Dysregulation in Major Depressive Disorder: Integrated Multi- Cohort Transcriptomic Analysis

This integrated multi-cohort transcriptomic analysis reveals that while peripheral PDCD4 expression levels remain stable in major depressive disorder, they are tightly correlated with T-cell immune signatures and inflammatory pathways, suggesting PDCD4 serves as a key peripheral immune correlate in depression pathophysiology despite lacking a direct causal link to disease risk.

Jing Ke, Pan Liu, Kun Hao, Luyuan Yao, Yang Liu2026-07-07
🧬 biology

Automated Classification and Quantification of Fungal Spores in Aerobiological Sampling Using Deep Learning

This study presents a deep learning-based approach using the YOLO26l model that significantly accelerates and standardizes the detection and quantification of eight fungal genera in aerobiological samples, achieving high accuracy and strong correlation with manual counts while reducing processing time from hours to under two minutes.

Dámaris A. Jiménez-Uribe, Deyson Gómez Sánchez, Jeison D. Jimenez, Rosa Acevedo-Barrios, Carolina Rubiano-Labrador, Hern (…)2026-07-07
🧬 biology

Species Composition, Feeding Behaviour and Plasmodium falciparum infectivity of Malaria Vectors along an altitudinal gradient in parts of Plateau State, Nigeria

This 2023 study in Plateau State, Nigeria, characterized the species composition, feeding behaviors, and *Plasmodium falciparum* infectivity of malaria vectors, revealing *Anopheles gambiae* sensu lato as the dominant species with high human-biting rates and significant sporozoite prevalence, thereby underscoring the need for continuous surveillance and the consideration of behavioral plasticity in vector control strategies.

Hayward Babale Mafuyai, Ishaya Tanko, Georgina Samuel Mwansat, Nentawe Gurumdimma, David Enekai Oguche, Eche Onah Otakpa (…)2026-07-06
🧬 biology

In Silico Screening and Molecular Dynamics Validation of Bryophyllum Pinnatum Flavonoids as Pi3kγ Inhibitors For Rheumatoid Arthritis

This study utilizes a comprehensive in silico workflow, including molecular docking, ADMET profiling, MM-GBSA calculations, and 100 ns molecular dynamics simulations, to identify luteolin, quercetin, and kaempferol from *Bryophyllum pinnatum* as potent and stable PI3Kγ inhibitors with promising therapeutic potential for treating rheumatoid arthritis.

Success O. Olubode, Olamide V. Awelewa, Samuel O. Olubode, Lateef Bello, Olufemi A. Akinola, Oluwafemi S. Bakare, Samuel (…)2026-07-06
🧬 biology

Microbial successional dynamics during Thalassia testudinum polycyclic aromatic hydrocarbons rhizoremediation

This study demonstrates that the seagrass *Thalassia testudinum* significantly enhances the rhizoremediation of recalcitrant polycyclic aromatic hydrocarbons in coastal sediments by releasing oxygen and stimulating diverse microbial communities, with nutrient addition further accelerating degradation and enriching aerobic hydrocarbonoclastic taxa.

Alonso de la Garza Varela, Ma. Leopoldina Aguirre-Macedo, Brigitta I. van Tussenbroek, José Q. García-Maldonado2026-07-06