1588 papers
This study utilizes a comprehensive in silico workflow, including molecular docking, ADMET profiling, MM-GBSA calculations, and 100 ns molecular dynamics simulations, to identify luteolin, quercetin, and kaempferol from *Bryophyllum pinnatum* as potent and stable PI3Kγ inhibitors with promising therapeutic potential for treating rheumatoid arthritis.
This study demonstrates that phosphorus starvation in wheat, particularly in landrace genotypes, expands the rare rhizospheric bacterial biosphere and alters functional potential without significantly disrupting the core microbiome structure, offering insights for microbiome-informed breeding and nutrient management strategies.
This study demonstrates that the seagrass *Thalassia testudinum* significantly enhances the rhizoremediation of recalcitrant polycyclic aromatic hydrocarbons in coastal sediments by releasing oxygen and stimulating diverse microbial communities, with nutrient addition further accelerating degradation and enriching aerobic hydrocarbonoclastic taxa.
This paper proposes and empirically validates a multi-level process model of extinction as the gradual collapse of semiotic systems, demonstrating that a measurable index of semiotic overlap (SO) across six biological kingdoms serves as a superior predictive indicator of population decline compared to classical demographic or variance-based early-warning signals.
This study demonstrates that the metabolic heat generated by aggregating larval masses acts as a "carrion furnace" that significantly accelerates carcass decomposition through a self-reinforcing feedback loop, highlighting the critical need to account for this thermogenic effect to improve the accuracy of post-mortem interval estimations in forensic taphonomy.
scLodestar is a scalable, high-performance framework that models single-cell data as continuous probability distributions over landmark states, enabling principled uncertainty quantification, the discovery of transitional cell populations, and efficient processing of millions of cells without the limitations of discrete hard clustering.
By integrating multi-omics and spatial profiling across 39 cancers, this study redefines ISG15⁺ T cells as a "spring-loaded" transitional reservoir that is spatially tethered in the tumor core but can be mobilized into active effectors by immune checkpoint blockade, thereby serving as a robust predictive biomarker for therapeutic success.
This study demonstrates that exposure to the water-soluble fraction of diesel oil, particularly at higher concentrations and combined with elevated seawater temperatures, significantly activates the innate immune system of the Antarctic sea urchin *Sterechinus neumayeri*, as evidenced by increased phagocytic activity and specific coelomocyte responses.
This study demonstrates that PNA-TPP reduces cisplatin tolerance in A549 lung adenocarcinoma stem-like spheres by upregulating Drp1 to induce mitochondrial dysfunction, thereby impairing stemness and enhancing drug sensitivity.
This study proposes an explainable neurodynamic framework for epileptic seizure classification that transforms 1D EEG signals into CWT scaleograms and processes them through a modified, fully convolutional DenseNet architecture, achieving superior accuracy and interpretability compared to various baseline models.