3881 papers
This study identifies Grem2⁺ dental follicle stem cells as a distinct, endogenous progenitor population essential for alveolar bone homeostasis and molar morphogenesis, revealing that Grem2-mediated regulation of BMP and IGF2 signaling prevents premature stem cell exhaustion and ensures proper bone formation.
This study reveals that contrary to expectations, reduced CXCL1 expression in triple-negative breast cancer promotes tumor aggressiveness and correlates with poor patient survival, suggesting a context-dependent tumor-restraining role for this chemokine.
This study demonstrates that the NSP2 paralog LjNSP2L in *Lotus japonicus* possesses distinct regulatory functions from its homolog LjNSP2, specifically mediating phosphate-dependent nodulation responses through its preferential induction under low-phosphate conditions.
This study establishes the first abiotic-stress lncRNA framework for sunflower, revealing that drought and salinity recruit largely distinct non-coding RNA populations converging on a compact dual-responsive core involving jasmonate signaling and water-channel activity, with genotype-specific mRNA partner responses offering candidates for resilience breeding.
This study demonstrates that relying solely on genomic annotations significantly inflates estimates of two-domain NucS occurrence and NucS/MutS-MutL coexistence across prokaryotes, whereas validation with profile hidden Markov models reveals that such coexistence is rare and taxonomically concentrated primarily in Halobacteria and Deinococcota.
This study presents a cost-effective, near-complete telomere-to-telomere genome assembly and comprehensive annotation of the subtropical maize inbred line CML312 using only standard Nanopore simplex reads, providing a scalable paradigm for complex plant genome assembly and a critical resource for mining stress-tolerance alleles.
This systematic review and meta-analysis of 31 MRI datasets reveals that individuals with ADHD exhibit significantly reduced global efficiency in structural brain networks, indicating compromised information integration, alongside exploratory evidence of nodal abnormalities in key regions like the caudate and orbitofrontal cortex.
This scoping review maps the current landscape of ethical, legal, and social implications (ELSI) in AI-assisted genetic diagnosis, revealing that most existing scholarship fails to address the unique intersection of AI and genomics, thereby highlighting an urgent need for genetically-specific governance frameworks and fairness audits.
This study demonstrates that an LRP1-targeted block peptide engineered to form liquid-liquid phase separation condensates on the cell surface significantly amplifies receptor signaling and therapeutic efficacy, effectively alleviating hepatic inflammation, lipid dysfunction, and fibrosis in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH).
This study reveals that the African swine fever virus protein pI10L unexpectedly enhances antiviral immune responses by interacting with MAVS to promote TRAF6 recruitment and stability, thereby boosting IFN-β and IL-6 production.