3881 papers
This study identifies *Nyctanthes arbor-tristis* as a superior source of antibacterial phytochemicals against multidrug-resistant pathogens, highlighting α-tocopherol-β-D-mannoside as a promising lead candidate through integrated GC-MS profiling, in vitro assays, ADMET prediction, and molecular docking.
Using ultra-high-resolution 50µm ex vivo MRI, this study reveals that early Alzheimer's disease (Braak stage II) is characterized by distant, layer-specific atrophy in the anterior CA1 and subiculum regions, which is strongly driven by tau pathology in upstream entorhinal areas rather than local tau burden.
This study employs an integrated network pharmacology, molecular docking, and molecular dynamics approach to elucidate that chrysin exerts anti-diabetic effects by simultaneously targeting key proteins like GSK3β and modulating critical pathways such as PI3K/Akt and NF-κB to regulate glucose metabolism, inflammation, and oxidative stress.
This study demonstrates that the widespread genetic coupling between disease and fertility, particularly through antagonistic pleiotropy where disease-risk variants increase reproductive success, is a key evolutionary driver shaping the varying prevalence of human diseases.
This paper demonstrates that the signature negative trend in the conservation–divergence spectrum is largely an artifact of its permutation null model and that protein language models' per-position coupling signals are predominantly driven by phylogeny rather than functional mechanism, establishing a rigorous framework for cross-examining black-box models against independent evolutionary evidence.
This paper introduces an auditable, eleven-level complexity ladder protocol for artificial life mechanism experiments that ensures rigorous, reproducible claims through prospective freeze criteria, failure retention, byte-safe RNG isolation, and explicit evidence grading, demonstrated via a minimal-cell model while transparently disclosing methodological limitations and past analytical errors.
This paper proposes that the Future Anticipation Maximisation (FAM) principle, where individuals locally maximize the diversity of future perceptual states through mutual anticipation, spontaneously generates and maintains critical-like collective dynamics and morphological transitions in animal groups without requiring fine-tuning or explicit alignment rules.
This pre-registered, leakage-safe benchmark demonstrates that the ability of basal transcriptome expression to predict context-specific drug responses is fundamentally limited by the low reproducibility of the target signal, with meaningful prediction only emerging for a small subset of drugs where the residual response is sufficiently reliable.
HADIA-KB is an evidence-preserving digital knowledge infrastructure that aggregates and maps fragmented scientific and cultural data on Jharkhand's traditional rice beer into a reproducible, source-proven graph, explicitly highlighting documentation gaps and regional variations rather than consolidating diverse traditions into a single narrative.
This paper introduces GRP, a general-relativity-inspired framework that models protein state spaces as coordinate-aware geometric manifolds to identify stable invariants linking AI representations to biological constraints, demonstrating that a few dominant modes capture most conformational variance and that structured biological paths exhibit distinct transport properties compared to null models.