3881 papers
This study presents the first chromosome-level genome assembly of the farmed white jade snail, revealing its close phylogenetic relationship and conserved synteny with the wild giant African snail (*Achatina fulica*) while highlighting functional divergences in metabolic and stress-response pathways associated with domestication.
This study combines morphological examination and molecular phylogenetic analysis to demonstrate that *Illiosentis cetratus* is genetically distinct from other *Illiosentis* species, thereby justifying the reinstatement of the genus *Tegorhynchus* for this species.
This multimodal computational study of the PPMI dataset suggests that Parkinson's disease hallucinations arise from a progressive disruption in the arbitration between sensory evidence and prior expectations, characterized by reduced sensory sensitivity and increased noise-driven false alarms that are strongly predicted by dopaminergic degeneration and GBA mutation status, despite significant limitations in precisely estimating the core arbitration parameter from single-visit behavioral data.
This paper introduces intracavity nuclear elastography, a nonlinear sensing platform that integrates living cells into a microcavity laser to amplify minute ultrasound-induced nuclear deformations via bifurcation dynamics, achieving over 120-fold higher sensitivity than conventional methods for quantitative, non-invasive mapping of nuclear mechanics and multidimensional cellular phenotyping.
This study demonstrates that a machine learning framework utilizing promoter-associated 5-hydroxymethylcytosine (5hmC) signatures from cell-free DNA can effectively and accurately distinguish cancer from healthy samples, offering a promising non-invasive strategy for early cancer detection and precision oncology.
This study demonstrates that glioblastoma invasion can be maintained as a stable, cell-intrinsic regulatory state driven by coordinated epigenetic remodeling and transcription factor networks (specifically ATF4 and MYC/MAX), which significantly stratify patient survival and offer potential therapeutic targets.
This study demonstrates that the gut microbiome composition and predicted functional potential of wild and captive black capuchin monkeys differ significantly, with captive individuals exhibiting greater microbial richness and distinct taxonomic and metabolic profiles likely driven by differences in diet, environment, and husbandry conditions.
This study employs a reproducible integrated splicing analysis pipeline on esophageal adenocarcinoma RNA-seq data to identify novel, underreported regulatory splicing junctions in the noncoding RNAs GAS5 and PVT1 that are absent from existing TCGA and GTEx catalogs, thereby providing a new framework for investigating noncoding splicing alterations in this disease.
This study utilized an ensemble-based Random Forest classifier and regressor on eye-tracking data from a visuo-spatial game to successfully categorize players into distinct behavioral groups, distinguishing between solvers (experts and persistent players) and non-solvers (triers and quitters) based on their gaze and gameplay patterns.
This study reveals that saprotrophic soil microorganisms occupy higher trophic positions than traditionally assumed by shifting their resource use from plant-derived to microorganism-derived amino acids as detritus quality declines and nutrient limitations increase.