3881 papers
This study demonstrates that the mesencephalic locomotor region (MLR) actively shapes decision-making during movement by encoding multiplexed motor and decision variables, driving evidence accumulation, and causally influencing go-decision probability.
This study presents an AI-driven pipeline that successfully identified and validated a novel quorum sensing peptide, GIVL, from the human gut microbiome as a potent α-glucosidase inhibitor that improves glucose homeostasis in diabetic mice, establishing a new framework for discovering microbiome-derived therapeutics for metabolic diseases.
This study reveals that adult and young barley leaves employ distinct antioxidant strategies in response to water deficit, with the tolerant Saïda landrace exhibiting unique age-dependent redox adjustments in adult leaves that contribute to its overall drought tolerance.
This paper describes *Achenotus moche*, a new genus and species of spider beetle from the Peruvian Coastal Desert, detailing its unique morphological adaptations to hyperarid conditions, its distribution across three regions, preliminary molecular phylogenetic data, and the ecological and conservation challenges associated with this endemic taxon.
This study demonstrates that applying noisy galvanic vestibular stimulation (nGVS) in a higher frequency range (10–30 Hz) significantly improves vestibular direction-recognition thresholds and manual control performance in healthy subjects, whereas a lower frequency range (0–2 Hz) overlapping with natural motion frequencies yields no such benefits.
This study identifies Gpatin, a small-molecule inhibitor that targets the essential bacterial enzyme PlsY by binding to a unique membrane-exposed pocket and inducing conformational changes to disrupt catalysis, thereby demonstrating potent in vitro and in vivo efficacy against multidrug-resistant Gram-positive pathogens.
This study introduces the Cattle Metabolome Atlas, a comprehensive resource linking genetic variants to thousands of circulating metabolites across dynamic physiological stages, thereby revealing tissue-specific regulatory mechanisms, causal gene-metabolite-trait cascades, and evolutionary conservation with humans to advance cattle breeding and comparative biology.
This study investigates the spatial expression of miR-17-5p in breast cancer tissues from the NOWAC cohort and its functional effects in vitro, suggesting an oncogenic role characterized by associations with younger age, premenopausal status, and increased tumor aggressiveness despite limited statistical significance.
This study demonstrates that simulated microgravity induces significant alterations in the cell envelope composition, morphology, and surface properties of *Escherichia coli*, leading to reduced hydrophobicity and decreased susceptibility to specific antibiotics.
Through integrated transcriptomics, single-cell sequencing, and experimental validation, this study identifies TREM2, PLD4, and CD247 as key phagocytosis-related biomarkers in traumatic brain injury, highlighting a novel role for PLD4+ NKT cells in post-injury immunometabolic reprogramming.