3881 papers
This study provides the first detailed characterization of the reproductive cycle of the brittle star *Ophiactis asperula* in Patagonia, revealing a gonochoric species with a bimodal gametogenic pattern synchronized with seasonal environmental changes and supporting a planktotrophic larval strategy.
This paper proposes a computationally efficient constrained constructive optimisation framework that generates patient-specific coronary microvascular networks by integrating existing epicardial trees, optimizing terminal vessel connections, and enforcing myocardial wall thickness constraints, thereby enabling large-scale personalized perfusion modelling with validated accuracy.
This study demonstrates that the Amazonian catfish *Auchenipterichthys longimanus* acts as a viable seed disperser in the Tupé Reserve's flooded forests by consuming fruits and facilitating the germination of plant species such as *Ficus maxima* and *Myrciaria dubia* after passage through its digestive tract.
This study characterizes two multidrug-resistant opportunistic pathogens, *Myroides* sp. strain Awka-1 and *Bacillus* sp. strain Awka-1, isolated from hospital environments in Anambra State, Nigeria, by detailing their phenotypic resistance profiles, plasmid carriage, and phylogenetic relationships to establish baseline molecular markers for tracking environmental reservoirs of healthcare-associated infections.
Inspired by the cannibalism phenotype of senescent tumor cells, this study developed senescent tumor cell membrane nanovesicles (STCM-NVs) that leverage senescence-induced molecular and morphological membrane remodeling to significantly enhance tumor targeting affinity, circulation stability, and therapeutic efficacy compared to conventional biomimetic carriers.
This study demonstrates that tyrosine phosphorylation of the adaptor protein Dok-3 is essential for restricting *Leishmania donovani* infection in macrophages by facilitating its interaction with inhibitory phosphatases SHIP-1 and SHP-1, thereby regulating p38 MAPK–STAT1 signaling and endosomal trafficking to limit parasite survival.
A ten-year study of stone martens in western Poland revealed that their diet shifts seasonally from fruits in summer-autumn to small mammals and birds in winter-spring, with a notable preference for voles and a potential cumulative predatory impact on brown hares despite individual hare consumption being low.
This study reveals that Angiotensin II sustains glioblastoma stemness via a novel Ang II/ERα/PI3K/AKT/GLI-1 signaling circuit where GLI-1 acts as a co-activator of ERα, providing a strong rationale for repurposing the estrogen receptor degrader ICI-182,780 to target these stem cells and improve patient outcomes.
This paper benchmarks three mainstream unsupervised protein mutational effect predictors using large-scale deep mutational scanning data to provide practical guidelines for protein engineering while revealing consistent limitations in predicting gain-of-function mutations and residues within specific structural or physicochemical contexts.
Using individual-based simulations, this study demonstrates that the detectability of landscape-genetic signals is governed by complex interactions between habitat area, configuration, and dispersal ability, revealing that while corridors consistently increase genetic diversity, they often reduce the statistical detectability of landscape resistance by eroding genetic differentiation gradients.