3881 papers
This study utilizes single-cell RNA sequencing guided by Sox9-EGFP to construct a transcriptomic atlas of the corneal limbus, identifying distinct cell clusters and validating novel stem cell markers (Gabrp, Fmo1, Fmo2, and Alcam) essential for maintaining corneal epithelial homeostasis.
This study utilizes genome-resolved metagenomics to characterize the llama forestomach microbiome, reconstructing 165 metagenome-assembled genomes that reveal a high level of unexplored microbial diversity and key metabolic pathways for plant polysaccharide degradation essential to host nutrition.
The study introduces CDRPipe, a unified computational framework that integrates microarray and single-cell-derived transcriptomic perturbation data to overcome resource fragmentation, demonstrating that combining these complementary sources significantly expands therapeutic coverage and identifies higher-confidence drug repurposing candidates compared to using either resource alone.
This paper introduces a robust carrier co-precipitation method using calcium carbonate and magnesium sulphate to significantly improve the yield and streamline the extraction of algal exopolymeric substances from *Coscinodiscus radiatus* for downstream biotechnological applications.
This study analyzes 74 Iranian patients with hereditary spastic paraplegia using exome sequencing, achieving an 80% molecular diagnostic rate, identifying a high proportion of novel variants with *SPG11* as the most frequent mutated gene, and establishing diverse genotype-phenotype correlations to better understand the disease's genetic landscape in this population.
This study demonstrates that early neonatal treatment with the AMPA receptor potentiator CX1632 induces lasting improvements in survival, behavior, and synaptic function in Rett syndrome mouse models by rescuing neuronal maturation, whereas therapeutic efficacy declines significantly with later intervention, highlighting the critical importance of developmental timing for effective treatment.
This study reveals that lysine acetylation of the PKA catalytic subunit sustains kinase activity during mammalian sperm capacitation through a cAMP-independent mechanism that enhances ATP binding affinity and promotes holoenzyme dissociation.
This paper presents a multi-layer computational framework that integrates comparative modeling, AlphaFold 3 refinement, docking, and molecular dynamics simulations to effectively prioritize and validate structurally robust protein candidates from large-scale transcriptomic datasets.
This study reveals that activated memory CD4 T cells directly reprogram autoreactive naïve CD8 T cells toward an activated state via Enolase-1-dependent transcriptional changes, a mechanism that can be therapeutically targeted to reduce autoimmune diabetes progression in NOD mice.
This study elucidates the multi-target antifungal mechanism of L-carvone against *Botrytis cinerea* by demonstrating that it disrupts cell membrane biosynthesis, inhibits toxin production and reproduction, and induces irreversible oxidative damage through the suppression of long-term antioxidant systems, as revealed by integrated transcriptomic and metabolomic analyses.