1625 papers
Despite moderate-intensity exercise training, intermittent high-fructose corn syrup consumption in rats induced hippocampal neurodegeneration and orexin dysregulation alongside impaired glucose tolerance, with exercise offering only partial neuroprotection against these metabolic and cognitive deficits.
This study demonstrates that *Pseudomonas fluorescens* effectively biodegrades both PET sheets and PS blocks, with UV pretreatment significantly enhancing weight loss and structural deterioration through surface erosion and molecular cleavage, thereby offering a promising strategy for sustainable plastic waste valorization.
By analyzing ME/CFS gene expression signatures to identify metabolic pathways and matching them with potential therapeutics, this study demonstrates that pioglitazone, tideglusib, and MHY1485 can enhance mitochondrial metabolism in muscle cells, offering a novel framework for treating pathological fatigue.
This study employs an integrated multi-omics approach to identify specific coding and non-coding genes, including hub genes like KNL1 and KIF14, that serve as potential biomarkers and therapeutic targets for predicting recurrence and improving prognosis in triple-negative breast cancer.
This study demonstrates that the human LRRCC1 gene variant p.H69Q disrupts acentrosomal microtubule organizing center clustering, leading to defective meiotic spindle assembly, chromosome misalignment, and elevated egg aneuploidy.
This study demonstrates that endocytosis pathway activity varies across colorectal cancer molecular subtypes, correlates with key oncogenic signaling networks, and that low expression of the core adaptor AP2M1 specifically predicts improved survival in metastatic patients treated with anti-EGFR therapy, suggesting its potential as a biomarker for therapeutic stratification.
This paper establishes that evolutionary adaptation is fundamentally non-gradient due to an irreducible "evolutionary curl" arising from the non-commutativity of genotype-phenotype mapping and fitness gradients, a principle validated across 19 datasets and 180 populations with 100% support after resolving initial discrepancies.
This study demonstrates that desflurane exacerbates cognitive dysfunction and amyloid pathology in Alzheimer's disease mice by downregulating and altering the phosphorylation of hippocampal Syntaxin 1A, a deficit that can be reversed by STX1A overexpression, highlighting it as a potential therapeutic target for preventing anesthetic-induced neurocognitive disorders.
This study presents the first worldwide multicenter validation of the POLARIS preclinical polarizer, demonstrating its ability to rapidly and reproducibly produce hyperpolarized [1-¹³C]pyruvate across diverse biological models, imaging systems, and international research centers to enable standardized metabolic MRI for translational research.
This study demonstrates that high carbonate alkalinity under low salinity significantly reduces survival and induces metabolic depression, feeding compensation, and redox-energy remodeling in the Hong Kong oyster (*Crassostrea hongkongensis*), providing a theoretical basis for managing saline-alkaline aquaculture environments.