3881 papers
This study combines molecular simulations and experimental analyses to demonstrate that the D-periodic ordered assembly of Type I collagen significantly enhances platelet receptor recognition and adhesion stability compared to less ordered collagen structures.
This study characterizes a convergent, cefiderocol-resistant, carbapenem-resistant hypervirulent *Klebsiella pneumoniae* lineage (primarily ST383) circulating in both outpatient and inpatient settings in Romania, revealing that clonal OmpK35 truncation and incomplete genotype-phenotype correlation underlie the observed resistance mechanisms.
This study validates targeted mass spectrometry-based salivary profiling as a scalable and reliable method for monitoring physiological strain and circadian rhythms, demonstrating its ability to accurately detect exercise-induced molecular changes in controlled settings and track internal load in elite athletes over 16 months.
The paper proposes BSP (Bidirectional Semantic Proximity), a novel protein function prediction method that constructs a directed heterogeneous network integrating bidirectional PPI edges, hierarchical GO relationships, and annotation links to achieve superior accuracy and generalization across multiple species by leveraging bidirectional semantic propagation.
The paper introduces FUSION, a multimodal graph-based AI framework that integrates protein language model embeddings, AlphaFold2-derived structural topology, and conformational ensembles to accurately predict and interpret somatic cancer driver mutations, particularly for rare missense variants lacking prior clinical evidence.
The paper introduces PRS-CARV, a summary statistics framework that integrates annotation-informed rare variant burden scores with common-variant polygenic risk scores to significantly improve the prediction of lipid traits and advance precision medicine.
This study utilizes a biophysically relevant network model to demonstrate that the piriform cortex encodes odor frequency information (2Hz vs. 20Hz) through a highly distributed population mechanism, where trial-averaged activity enables high-accuracy discrimination that is bidirectionally modulated by specific circuit motifs involving feedback, feedforward, and recurrent connections.
This study identifies and characterizes thermostable α-amylases produced by *Bacillus* species isolated from Wanzaye Hot Spring in Ethiopia, demonstrating their optimal activity at high temperatures and broad pH ranges, as well as their high efficiency in hydrolyzing raw enset starch for potential industrial applications.
This study identifies a conserved, parasite-specific catechol-O-methyltransferase (BmMT) as a novel drug target for lymphatic filariasis and demonstrates that its selective inhibitors effectively eliminate *Brugia malayi* infections in vivo by blocking catecholamine metabolism.
This study developed an optimized culture medium (BH-SAM) by reducing specific growth factors to restore estrogen responsiveness in ER-positive breast cancer organoids, enabling reliable functional assays for screening endocrine therapy resistance and identifying personalized alternative treatments.