1625 papers
This study demonstrates that constructing modular mixed microbial cultures from substrate-specialized populations significantly enhances polyhydroxyalkanoate (PHA) accumulation and composition control from variable carboxylate feedstocks, including waste-derived acidogenic broths.
This study employs a multi-layer analytical strategy to reveal that stromal remodeling in steroid-associated osteonecrosis of the femoral head is a state-restricted, context-sensitive process where adipogenic rewiring is only partially coupled to a specific stress-adaptation program, rather than a uniform compartment-wide phenotype.
This study successfully developed a genetically marked *Phormia regina* blow fly strain expressing a fluorescent protein that retains normal development rates, thereby overcoming the technical barrier of tracking known-age larvae in the field to validate forensic age-estimation methods under realistic decomposition conditions.
This study characterizes the newly identified potato endophyte *Paenibacillus* sp. ST1, demonstrating how its physiological adaptations to the host environment enable stable colonization, improved plant growth, and enhanced viral tolerance through a mutualistic symbiosis.
This study demonstrates that the peach gene *PpSAT4* positively regulates adventitious root formation by modulating redox homeostasis, as evidenced by its conserved ability to enhance rooting traits and antioxidant enzyme activities in transgenic *Prunus salicina* and *Arabidopsis thaliana*.
This study characterizes *Lentilactobacillus buchneri* subsp. *silagei* strain AGA55 from Turkish shalgam through genome-resolved multi-omics, confirming its taxonomic identity, intrinsic safety, and significant probiotic potential evidenced by robust gastrointestinal survival, antioxidant activity, and selective cytotoxicity against colorectal cancer cells.
This study utilizes plasma proteomic profiling to demonstrate that the molecular pathways driving Alzheimer's disease and cognitive decline are distinct from those of normal aging, revealing unique signatures in immune, actin, and platelet-related proteins that offer new candidate biomarkers and therapeutic targets.
By integrating the largest single-cell and spatial atlas of brain malignancies, this study reveals that tumor evolution is driven by a balance of lineage-specific imprinting and convergent adaptation to a dominant mesenchymal state, which orchestrates distinct microenvironmental shifts and defines a specific proliferative niche that predicts severe clinical deterioration.
This study reveals that excess ammonium stress in *Nicotiana tabacum* triggers growth inhibition and metabolic shifts characterized by specific amino acid alterations and distinct transcriptional reprogramming, ultimately identifying six candidate transcription factors that regulate the plant's response to ammonium toxicity.
By integrating Mendelian randomization, single-cell, and bulk transcriptomic analyses, this study identifies LDHA and GRIK1 as key osteoarthritis biomarkers linked to the druggable genome and gut microbiome, with endothelial cells serving as pivotal mediators in the disease's underlying mechanisms.