q-bio papers | Gist.Science

Spatiotemporal Dynamics of Planktonic Bacterial Communities and Their Assembly Mechanisms in a Newly Created Riverine Reservoir

A seasonal study of the newly formed Guandaoqiao Reservoir reveals that while abundant and rare planktonic bacterial subcommunities share dominant taxa, they exhibit distinct seasonal assembly mechanisms—shifting from deterministic to stochastic processes for rare taxa—and that reservoir impoundment significantly weakens network robustness, with rare taxa serving as keystone species.

Yong Li, Jianping Wang, Jiankun Du, Yajie Li, Rui Zhu, Jiarui Liu, Lisiyi Lai, Zhilian Gong2026-08-31

🧬 biology

Lactylation-driven SENP1 promotes colon cancer malignant progression by mediating FRS2 deSUMOylation modification

This study reveals that histone H3K18 lactylation drives colon cancer progression by upregulating SENP1 transcription, which in turn stabilizes FRS2 via deSUMOylation to enhance tumor proliferation, metastasis, and glycolysis.

Yichen Li, Chenglong Shen, Yixin Tang, Jiazhe Shao, Haichen Liu, Yuchao Wang, Guoqiang Zhou, Zhi-Liang Shi2026-08-31

🧬 biology

Predicting Lassa Virus Glycoprotein Mutations Affecting Viral Entry and Antibody Escape

This study presents an integrated machine learning framework using XGBoost to predict how Lassa virus glycoprotein mutations affect viral entry and antibody escape, thereby identifying conserved epitopes and guiding the design of broadly effective vaccines and therapeutics.

Oluremi Israel Ajayi, Blessing Oluwatobi Olorunfemi, Jolly Amoche Adole, Amoge Chidinma Ogu, Ifeoluwa O. Bejide, Blossom (…)2026-08-31

🧬 biology

Integrated analysis of single-cell RNA sequencing and bulk RNA sequencing reveals T-cell-associated prognostic risk models and the regulation of the tumour immune microenvironment in colorectal cancer

By integrating single-cell and bulk RNA sequencing data, this study identifies a six-gene T-cell-related prognostic model for colorectal cancer that accurately stratifies patient survival risk and characterizes the associated immunosuppressive tumor microenvironment.

Xiangli Yin, Yiyan Zhai, Xiaodong Chen, Jiangying Liu, Haojia Wang, Peiying Lu, Junyi Li, Muyassar Mamattohti, Tianzhu Z (…)2026-08-31

🧬 biology

Ectomycorrhizal fungal inoculation promotes growth and enhances resistance of Larix gmelinii to Fusarium oxysporum

This study demonstrates that inoculating *Larix gmelinii* seedlings with a specific *Boletus edulis* and *Chroogomphus rutilus* fungal combination significantly enhances growth and resistance to *Fusarium oxysporum* by improving nutrient utilization, activating antioxidant defenses, and promoting phenolic metabolism.

Yuxuan Wang, Yajing Wei, Tianzhen Wang, Yuanyuan Wang, Jie Tang, Fei Wang, Laiye Qu2026-08-31

🧬 biology

Structure-guided prioritization of Andrographis paniculata diterpenoids at the PCSK9-LDLR interface

This study employs structure-guided computational analysis to prioritize andrograpanin over isoandrographolide as a superior scaffold for targeting the PCSK9-LDLR interface, distinguishing structural engagement from simple docking affinity despite the lack of experimental validation.

Muhammad Nazrul Hakim, Armania Nurdin, Mohd Sofian Omar Fauzee, Zuraini Ahmad2026-08-31

🧬 biology

Marine Mammal Reporting Records Along the Tamil Nadu Coast, India: A Five- Year Baseline for Wildlife Surveillance and Conservation

This study presents the first comprehensive five-year baseline (2020–2024) of marine mammal reporting records along the Tamil Nadu coast, analyzing 250 official reports to characterize species distribution, reporting patterns, and data gaps while highlighting the need for standardized protocols to enhance future conservation efforts.

Madeswaran Rengarasu, Thekke Thumbath Shameer, Senbagapriya Sekar, Sivaranjani Shankar, Udhayan Arumugam2026-08-31

🧬 biology

Intrinsically Disordered Regions in CAHS Proteins Govern Self-assembly and Enzyme Stabilization Against Multiple Stresses

This study demonstrates that intrinsically disordered regions in tardigrade CAHS proteins drive self-assembly to significantly enhance enzyme stability and biocatalytic efficiency against diverse abiotic stresses, offering a novel bioinspired platform for biotechnological applications.

Ana Benitez-Mateos, Manuel Pérez-Soto, Giacomo Fabrini, Marcos Gil-Garcia, Paolo Arosio2026-08-31

🧬 biology

Quasispecies variation of 5’ half-length genomes from HIV-1 CRF103_01B by single genome amplification

This study utilized single-genome amplification to characterize the intra-host quasispecies variation and minority drug resistance of HIV-1 CRF103_01B in Beijing MSM, providing insights into viral heterogeneity and its potential impact on antiretroviral therapy efficacy.

Man Dai, Jia Li, Xiyao Li, Mingfeng Xiao, Huixuan Wang, Ruolei Xin2026-08-31

🧬 biology

Longitudinal molecular and serological surveillance of elephant endotheliotropic herpesviruses through relocation in a captive herd of Asian elephants (Elephas maximus)

This two-year longitudinal study of nine captive Asian elephants undergoing relocation demonstrates that combining serological testing with trunk wash surveillance provides valuable insights into EEHV exposure and susceptibility, revealing that viral shedding in trunk washes often precedes viraemia and that antibody levels can increase in response to systemic infection.

Jack W. Wheelahan, Peter Münster, Paola K. Vaz, Alistair R. Legione, Sally J. Gazzard, Bonnie McMeekin, Willem Schaftern (…)2026-08-31

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