1625 papers
This study demonstrates that individual differences in neuroticism shape the neural organization of conditioned threat learning by reducing the brain's ability to differentiate threat from safety signals, a pattern that specifically links neural threat representations to anxiety vulnerability within high-neuroticism individuals.
This study demonstrates that the membrane-associated protein PALMD is upregulated in ovarian cancer spheroids, where it promotes spheroid integrity and anoikis resistance by suppressing p53-mediated apoptosis, thereby facilitating peritoneal metastasis.
This computational study utilizes molecular docking to demonstrate that certain environmental pesticides, particularly DDT, exhibit significant binding affinity to the human Estrogen Receptor Alpha, suggesting their potential to act as endocrine disruptors by competing with natural hormones.
This pilot study found that while a 12-week exercise rehabilitation program significantly improved functional and physiological parameters in cancer survivors, circulating miRNAs (with the exception of miR-126) showed limited responsiveness to the intervention and only modest associations with these physiological adaptations, suggesting a need for larger controlled studies to validate their utility as biomarkers.
This study demonstrates that adult mice lacking the ability to form new compact myelin sheaths or provide metabolic support via Mct1 retain intact motor and fear learning and memory, indicating that these cognitive processes rely on non-canonical properties of pre-myelinating oligodendrocytes rather than the canonical functions of myelin in speeding neural conduction.
This study demonstrates that oxidized phosphatidylcholines, generated by iron-induced lipid peroxidation in multiple sclerosis grey matter, trigger neuronal necroptosis and neurodegeneration, a process that can be ameliorated by inhibiting necroptosis.
This study utilizes c-Fos immunohistochemistry to demonstrate that while the lateral hypothalamus is activated by both sensing and eating a high-fat diet, the paraventricular nucleus and basolateral amygdala respond specifically to sensory exposure, whereas the nucleus accumbens, ventral tegmental area, and central amygdala are activated only upon consumption.
This study demonstrates that *Staphylococcus aureus* cells released from early-stage biofilms exhibit significantly enhanced adhesion forces and rupture lengths on various medical substrates compared to planktonic or late-stage biofilm-released cells, suggesting their critical role in initiating new implant-associated infections under flow conditions.
This study integrates transcriptomic and biochemical profiling to elucidate the regulatory networks governing key quality traits in *Camellia sinensis* 'Emei Wenchun' and establishes a high-resolution DNA fingerprinting framework using 150 SNP markers to accurately verify parentage and protect elite breeding lines.
This study reveals that granulosa cell development and BMP15 expression are key determinants of laying performance, while oviduct magnum morphology and ZDHHC2 expression significantly influence egg shape traits in Huaixiang chickens.