1625 papers
This study reveals that STING functions as a novel transmembrane channel in the endoplasmic reticulum that recruits Aster-escorted cholesterol from the plasma membrane to maintain cholesterol homeostasis, a mechanism whose disruption leads to altered cholesterol distribution and reduced systemic corticosterone levels.
This study presents the first single-cell RNA sequencing analysis of feline peripheral blood immune cells exposed to *Toxoplasma gondii*, revealing that while lymphocytes dominate the cellular landscape, myeloid cells—particularly monocytes and neutrophils—undergo the most significant transcriptional remodeling and engage in critical IL-1 and CSF2-mediated communication during infection.
This study demonstrates that sex-reversed XX male rainbow trout exhibit superior reproductive traits and a sperm biochemical profile enriched in long-chain polyunsaturated fatty acids compared to normal XY males, highlighting significant genotype-dependent variations in reproductive physiology and sperm composition.
This study reveals that *Lycium intricatum* in Sicilian coastal dunes hosts diverse fungal communities dominated by Ascomycota and arbuscular mycorrhizal fungi, confirming its mycotrophic nature and highlighting its potential as a key species for dune stabilization and habitat conservation.
This prospective cohort study of 97 healthy New Zealand females found no significant associations between subclinical ovulatory disturbances, menstrual cycle phases, and levels of perceived stress, cognitive dietary restraint, or mood.
This study employs activity-guided fractionation and proteomic analysis to identify 41 secreted proteins from a non-enterotoxigenic *Bacteroides fragilis* strain that synergistically inhibit colorectal cancer cell proliferation, offering new insights into microbiota-derived anti-cancer mechanisms.
This paper introduces HAEMF-PCR, a streamlined, cost-effective method for the seamless assembly of multiple DNA fragments using only a high-fidelity polymerase and terminal overlaps, which demonstrates superior cloning efficiency and scalability compared to traditional multi-enzyme homology assembly techniques.
This study identifies the adaptor protein MyD88 as a critical, environmentally responsive regulator that sustains melanoma metastatic competence by promoting integrin-mediated adhesion and plasticity, thereby enabling tumor cells to invade, intravasate, and colonize distant organs without affecting primary tumor growth.
This study identifies that a specific subset of reparative TGF-β⁺ MerTK⁺ M2c macrophages accumulates in denervated muscle and mitigates atrophy through TGF-β signaling and efferocytosis, suggesting a promising target for immunotherapeutic interventions.
This study reveals that elevated branched-chain amino acids impair autophagic flux in decidual stromal cells, triggering excessive senescence via the HSPA6/FOXO1 signaling pathway and leading to spontaneous abortion, a process that can be mitigated by restoring autophagy.