3881 papers
This paper introduces Skinteractome, an interactive online atlas that utilizes single-cell transcriptomics to map and visualize neuro-immune-stromal cell-cell communication networks within the human skin microenvironment under both healthy and inflammatory conditions.
This study integrates Mendelian randomization, bioinformatics, and machine learning to establish a causal link between type 2 diabetes and impaired tendon repair, identifying MYL2, MYL3, and TTN as key hub genes that likely disrupt healing through cytoskeletal dysfunction and macrophage-mediated immune alterations.
This paper introduces the µEFPocket, a conformal, ultrathin microfluidic biointerface fabricated from parylene C that enables simultaneous, high-resolution spatiotemporal chemical and electrical stimulation alongside optical and electrical recording in human brain organoids, thereby overcoming the challenges of 3D complexity to facilitate multimodal functional assays and closed-loop studies.
This study integrates pan-genome, phylogenomic, and compositional analyses to reveal that the globally dominant ST2 lineage of *Acinetobacter baumannii* relies on an open genome architecture where horizontally acquired antimicrobial resistance genes are stably maintained within genomic islands, underscoring the critical need for comprehensive genomic surveillance across chromosomes, plasmids, and phages to combat carbapenem resistance.
This study leverages population-scale long-read RNA-seq and multi-omics data from 432 dairy cows to construct a comprehensive bovine transcript atlas, revealing thousands of novel isoforms and context-specific regulatory variants that significantly improve the resolution of complex trait genetics and bridge the "missing regulation" gap left by traditional short-read methods.
This study demonstrates that *Bacillus cereus* XT-1, which upregulates the *nprC* gene to produce a key 35 kDa neutral protease, serves as an efficient and green biological agent for extracting high-yield, stable astaxanthin from shrimp shell waste with enhanced antioxidant activity.
This study demonstrates that while expanding populations of *Acropora cf. solitaryensis* and *A. aff. divaricata* at their climate-driven poleward margin maintain high host genetic diversity and connectivity, they exhibit distinct Symbiodiniaceae assemblages characterized by a shift from C3-radiation to C1-radiation symbionts, likely driven by lower seawater temperatures.
This review proposes an integrative evolutionary framework demonstrating how plant sexual reproduction, originating in ancestral green algae over a billion years ago, diversified across terrestrial lineages through the iterative co-option, duplication, and rewiring of conserved genetic modules such as MADS-box transcription factors and hormonal systems.
This paper proposes a two-step feature selection framework that combines variance-based hard filtering with XGBoost to reduce 61 million SNPs to a computationally tractable subset, enabling efficient machine learning-based geographic origin prediction on large-scale genomic datasets without prohibitive resource requirements.
This cognitive-computational case study demonstrates that severe trypophobia arises not solely from low-level visual properties but from an integrative process where initial visual triggers are amplified by top-down cognitive appraisals of disease and contamination threats.