q-bio papers | Gist.Science

A Probiotic-Derived Oxydifficidin from Bacillus subtilis Y4 Combines Direct Antibacterial Activity and Immunomodulatory Effects Against Multidrug-Resistant Acinetobacter baumannii Infection

This study identifies oxydifficidin, a probiotic-derived metabolite from *Bacillus subtilis* Y4, as a promising therapeutic agent that combats multidrug-resistant *Acinetobacter baumannii* infections through direct membrane-disrupting antibacterial activity and immunomodulatory effects that reduce lung inflammation and bacterial burden in immunosuppressed mice.

Xinyuan Li, Haowen Yan, Jinyu Mou, JinYang Gu, Lili Guan, Jingrui Chen, Lingcong Kong, Hongxia Ma, Haipeng Zhang2026-07-03

🧬 biology

AlGaN/GaN heterojunction field effect transistor structure integrated photoelectrode probe with optical artifact suppression function

This paper presents an integrated photoelectrode probe utilizing AlGaN/GaN heterojunction field-effect transistors with a differential recording architecture to simultaneously stimulate neurons and acquire high-quality electrophysiological signals while suppressing optical artifacts by 90%.

Xin Cao, Yanyuan Ding, Xi'en Yang, Wenbo Zhao, Xiaodong Li, Ye Wen, Yang Li, Xilei Huang, Zeyi Li, Jiefeng Weng, Baijun (…)2026-07-03

🧬 biology

Isolation and screening of amylase producing bacteria from sewage water and soil receiving kitchen waste

This study conducted at Debre Berhan University, Ethiopia, successfully isolated and screened amylase-producing bacteria from sewage water and kitchen waste-contaminated soil, revealing that 50% of the ten bacterial isolates were amylase producers, with a higher prevalence (60%) found in soil samples compared to sewage water (40%).

Shumate Kebede Hirpa2026-07-03

🧬 biology

Evaluation of octocoral-specific primers for environmental DNA (eDNA) metabarcoding of the coral reefs of Okinawa, Japan

This study evaluates three primer sets for octocoral eDNA metabarcoding in Okinawa and identifies a new mtMutS primer set as the most effective tool for detecting octocoral biodiversity, outperforming existing markers in both mock communities and field samples.

Agus A. Hakim, Fabian Gösser, Jue Alef A. Lalas, Emmeline A. Jamodiong, Anže Abram, Ulla von Ammon, Guillermo M. Castell (…)2026-07-03

🧬 biology

Astrocytic LRP4 Mediates Gliovascular Remodeling after Pilocarpine-Induced Status Epilepticus

This study demonstrates that overexpressing astrocytic LRP4 during the latent phase of pilocarpine-induced status epilepticus mitigates hippocampal sclerosis and seizure progression by shifting reactive astrocytes toward a vascular-supportive repair state and enhancing gliovascular communication.

Meiying Zhang, Liting Zheng, Siying Tang, Jianghao Wang, Zheng Yu2026-07-03

🧬 biology

Mid-infrared spectroscopy and supervised machine learning can determine age class of arboviral vector Culex pipiens at high age resolution

This study demonstrates that mid-infrared spectroscopy combined with supervised machine learning can accurately determine the age class of the arboviral vector *Culex pipiens* with high resolution, offering a promising tool for assessing pathogen transmission risks and evaluating vector control strategies.

Ryan McCaffrey Carmichael, Mauro Pazmiño-Betancourth, Jean-Philippe Parvy, Sai Kulkarni, Jaimie T A Dick, Katarzyna Modr (…)2026-07-03

🧬 biology

Astroglial noradrenaline shapes cerebellar synaptic integration and motor adaptation

This study reveals that Bergmann glia serve as a local source of noradrenaline in the cerebellum, where calcium-dependent release via VMAT2 modulates synaptic integration in Purkinje neurons to drive adaptive motor behavior despite sparse traditional noradrenergic innervation.

Glenn Dallérac, Sambre Mach, Juliette Royer, Wenli Niu, Xia Li, Rafael Benzi, Nathalie Desvignes, Julien Bouvier, Micael (…)2026-07-03

🧬 biology

Literature Review: Early Life Stress, Immune Dysregulation, and Sex Differences In Adolescent Neurodevelopment

This literature review synthesizes evidence demonstrating that early life stress and biological sex independently and interactively shape adolescent neurodevelopment and immune function through shared critical periods mediated by the HPA and gonadal axes.

Rasya Aprilio Rosyidi, Moses Glorino Rumambo Pandin2026-07-03

🧬 biology

Cross-kingdom phenotype annotations for 35,856 species generated with a web-search-enabled language model

This paper presents a comprehensive cross-kingdom phenotype dataset comprising over 7 million annotations for 35,856 animal, plant, and fungal species, generated through a web-search-enabled large language model pipeline to facilitate broad-scale comparative biology and conservation research.

Tyler M. Moore2026-07-03

🧬 biology

Cross-gene kinase domain hotspot analysis with AI pathogenicity prediction identifies FGFR2 D650G as a candidate actionable variant

This study presents a computational framework combining cross-gene mutation mapping and AI-driven pathogenicity prediction to identify and functionally validate the FGFR2 D650G variant as a novel actionable driver sensitive to FDA-approved inhibitors, offering a strategy to resolve the clinical ambiguity of variants of unknown significance in precision oncology.

Teruki Tsunashima, Kosuke Maruyama, Emi Ogawa, Nguyen Thai Le, Takashi Kohno, Takashi Nakaoku2026-07-03

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