🧬 Category

q-bio

1625 papers

🧬 biology

Dietary Cocos nucifera milk mitigates D-galctose-induced aging and neurotoxicity in Drosophila melanogastervia modulation of oxidative stress and neurotransmitter dysfunction

This study demonstrates that dietary coconut milk mitigates D-galactose-induced aging and neurotoxicity in *Drosophila melanogaster* by modulating oxidative stress and neurotransmitter dysfunction, a mechanism supported by the high binding affinity of its bioactive component, oleic acid, to key enzymes like AChE and GST-2.

Muideen Tunde Arogundade, Rafiu Adekunle Raji, Kamiludeen Ayinla Jimoh, Tope Atere Gafar2026-07-03
🧬 biology

Constant recruitment annihilates limit cycles in environmentally transmissible disease models

This study demonstrates that assuming constant population recruitment in environmentally transmissible disease models can erroneously predict stable equilibrium states, whereas incorporating exponential or logistic recruitment reveals critical Hopf bifurcations and sustained oscillations, highlighting the necessity of accurate recruitment specifications to avoid misleading public health predictions.

Hemaho B. Taboe, Sergei S. Pilyugin, Calistus N. Ngonghala2026-07-03
🧬 biology

The Warburg Effect Hallmark in Nasopharyngeal Carcinoma: Stage-Specific Up-Regulation of LDHA, GAPDH, CS, CYC, MRPL3, and TIMMDC1 Drives a Hybrid Glycolysis/OXPHOS Profile during Regional Progression

This study utilizes transcriptomic analysis to demonstrate that nasopharyngeal carcinoma progression is driven by a stage-specific hybrid metabolic phenotype, characterized by the coordinated up-regulation of six core genes (LDHA, GAPDH, CS, CYC, MRPL3, and TIMMDC1) that activate both glycolysis and oxidative phosphorylation during advanced regional disease.

Maria-Jose Oliach, Antonio R. Romeu2026-07-03
🧬 biology

Connectivity patterns in the DMN that are impacted by traumatic stress

Using a rat model of traumatic stress, this study reveals that while single prolonged stress generally decreases default mode network connectivity and disrupts its natural evolution, it paradoxically enhances specific connectivity patterns during extinction testing, particularly involving the anterior cingulate cortex and rostral retrosplenial cortex.

Dayan Knox, Negin Mohammadmirzaei, Simone Lunn, Praveen Kulkarni, Matthew Biddle, Alyssa Burlack, Aryan Mehta, Emma Lope (…)2026-07-03
🧬 biology

Multi omics reveals mesodermal fate bias and enables predictive cell state control in human pluripotent stem cell biomanufacturing

This study employs multi-omics profiling and random forest modeling to characterize how engineered bioprocess conditions influence human pluripotent stem cell states, revealing mesodermal fate biases and establishing a predictive framework for optimizing cell maintenance and differentiation in biomanufacturing.

James Colter, Tiffany Dang, Daniel Young, Antoine Dufour, Ian Lewis, Kartikeya Murari, Michael Scott Kallos2026-07-03
🧬 biology

Genome-based reclassification of Lentzea roselyniae (Okoro et al. 2010) Nouioui et al. 2018 and Lentzea terrae Li et al. 2018 as later heterotypic synonyms of Lentzea atacamensis (Okoro et al. 2010) Nouioui et al. 2018 and Lentzea soli Li et al. 2018, respectively

This study utilizes comprehensive genome-based analyses, including ANI, dDDH, and phylogenomic data, to demonstrate that *Lentzea roselyniae* and *Lentzea terrae* are later heterotypic synonyms of *Lentzea atacamensis* and *Lentzea soli*, respectively, and proposes their formal reclassification.

Xin-Ran Wang, Shuai Li, Wen-Jun Li, Wei Zhang2026-07-03
🧬 biology

Proteomic analysis reveals 4-methylumbelliferone-induced metabolic shift and downregulation of CD147/MMP2 axis in U937 Cells

This study demonstrates that 4-methylumbelliferone (4MU) exerts antitumor effects in AML U937 cells through a hyaluronic acid-independent mechanism involving a metabolic shift toward oxidative phosphorylation and the downregulation of the CD147/MMP-2 axis.

Mariángeles Díaz, Martín M. Ledesma, Tomás Lombardo, Matías Pibuel, Silvia E. Hajos, Rafael J. Argüello, Pía Valacco, Da (…)2026-07-03
🧬 biology

A hierarchical face-scalp-cortex mapping for non-invasive neuromodulation targeting without magnetic resonance images guidance

This paper presents a unified hierarchical face-scalp-cortex mapping framework that enables precise, MRI-free non-invasive neuromodulation targeting by establishing latent correlations between external facial features and internal brain structures, a capability validated through experiments on phantoms and insomnia patients using a markerless robotic neuronavigation system.

Guanglong Du, Jingwei Liu, Liying Zhang, Jianping Chu, Yinan Ai, Mingyu Yin, Min Chen, Mingtian Yu, Wei Li, Lei Liu, Sij (…)2026-07-03