🧬 Category

q-bio

3881 papers

🧬 biology

Finger-Specific Electrotactile Sensation and Its Sensorimotor Cortical Substrates During TENS: A Combined Psychophysical and MEG Investigation

This study establishes that finger-specific electrotactile detection thresholds vary across digits in healthy adults and demonstrates that transcutaneous electrical nerve stimulation (TENS) engages distinct early somatosensory cortical responses and transient alpha- and beta-band sensorimotor network coupling, providing a normative framework for developing individualized, digit-specific rehabilitation protocols for stroke recovery.

Jintao Lai, Dekun Yang, Yegang Hu, Jiabei He, Jing He, Chunlei Shan, Ning Jiang, Xiaoli Guo, Yao Chen, Xiaohong Sui2026-08-28
🧬 biology

Dynamics of peripheral T cell phenotype and function during tuberculosis disease progression

This longitudinal study of adolescents reveals that while systemic inflammation drives significant changes in peripheral T cell activation and differentiation during tuberculosis progression, the frequencies and functions of Mtb-specific T cell subsets do not directly correlate with disease progression.

Virginie Rozot, Miguel Rodo, Carly Young-Bailie, Munyaradzi Musvosvi, Constance Schreuder, Phu Van, Greg Finak, Evan Gre (…)2026-08-28
🧬 biology

Automated in situ CryoET Structure Determination with a Self-Configuring Workflow

This paper introduces an automated framework that integrates the self-configuring deep-learning detector Octopi with the standardized py2rely workflow to enable high-resolution (3–20 Å) in situ cryo-electron tomography structure determination across diverse biological samples with minimal expert intervention.

Dari Kimanius, Jonathan Schwartz, Daniel Ji, Utz Ermel, Joshua Hutchings, Rahel Woldeyes, Zhuowen Zhao, Christof Henkel (…)2026-08-28
🧬 biology

Dynamic connectivity patterns in Parkinson's disease: A new framework for postural control assessment with BioVRSea

This study utilizes the BioVRSea paradigm and EEG source connectivity analysis to reveal that early-stage Parkinson's disease is characterized by frequency-specific (delta, theta, and beta) alterations in dynamic brain network states during postural control, indicating reduced neural flexibility and abnormal stabilization of connectivity patterns that serve as potential biomarkers for postural dysfunction.

Federica Pescaglia, Lorena Guerrini, Carmine Gelormini, Gylfi Thormar, Giorgio Di Lorenzo, Halldór Jónsson, Hannes Peter (…)2026-08-28
🧬 biology

PBMC-derived TBX21/GATA3 and RORC2/FOXP3 expression ratios are associated with thyroid autoantibody positivity in adults with type 1 diabetes: an exploratory cross-sectional study

In an exploratory cross-sectional study of adults with type 1 diabetes, PBMC-derived TBX21/GATA3 and RORC2/FOXP3 expression ratios were significantly associated with thyroid autoantibody positivity, despite a lack of concordance between these transcript ratios and corresponding circulating CD4+ cell phenotypes.

Wei Chen, Muxian Zhong, Xinrong Xie, Xuejun Mo, Wuxiang Huang2026-08-28
🧬 biology

Deep learning-driven multi-omics integration reveals potential ferroptosis-associated mechanisms of Chinese herbal medicines in colorectal cancer

This study employs an AI-driven multi-omics framework to screen Chinese herbal medicines for colorectal cancer treatment, identifying five candidates that potentially regulate ferroptosis and metabolic pathways through mechanisms involving iron homeostasis, lipid peroxidation, and IL-6/STAT3 signaling.

Tingting Hao, Ya Ning, Mengli Zhang, qiao zhu, dawei li, die jiang, yanqi liu, Xingzhi Yang, Xing Jiang, Xiaolei zhou, d (…)2026-08-28
🧬 biology

Linking genetic connectivity and habitat occupancy through environmental resistance in fragmented landscapes

This study demonstrates that integrating microsatellite-based genetic data with remote-sensing environmental predictors to model landscape resistance effectively predicts habitat patch occupancy in fragmented landscapes, thereby providing a practical framework for identifying priority conservation areas for *Ctenomys mendocinus*.

Marcelo J. Kittlein, Fernando J. Mapelli2026-08-28
🧬 biology

Rhizosphere biochemical and microbial community patterns across documented penicillin application histories: a blocked citrus-orchard study

This blocked field study in a commercial mandarin orchard found that documented penicillin application histories are associated with coordinated, non-linear changes in rhizosphere soil biochemistry and microbial community composition, though the retrospective nature of the data supports these findings as field associations rather than definitive causal evidence of cumulative penicillin effects.

Li Liu, Yuan Zhao, Yuanfu Li, Qinyu Lu, Simiao Chen, Yuyan Qin, Yunru Wang, Qian Qin, Bin Shan2026-08-28
🧬 biology

Microtubule-associated protein HAUS8 regulates glioma proliferation, invasion and migration through EMT mediated by RhoA/ ROCK1

This study demonstrates that the microtubule-associated protein HAUS8 drives glioma proliferation, invasion, and migration by promoting epithelial-to-mesenchymal transition via the RhoA/ROCK1 signaling pathway, establishing it as a critical prognostic biomarker and potential therapeutic target.

Hongyue Huo, Xiufang Tang, Jin Zhu, Jun Lu, Xiaolin Wang, Kai Wang, Jianxin Jiang, Yanhua Xu2026-08-28