q-bio papers | Gist.Science

Nicotinamide Mononucleotide Restores Pancreatic β-Cell Function in Type 2 Diabetes through SIRT6-HIF-1α-Mediated Mitochondrial Stress Adaptation and Glycolytic Reprogramming

This study demonstrates that Nicotinamide Mononucleotide (NMN) restores pancreatic β-cell function in Type 2 diabetes by activating the SIRT6-HIF-1α signaling axis to drive mitochondrial stress adaptation and glycolytic reprogramming, thereby alleviating hyperglycemia-induced cellular injury and preserving islet integrity.

Yajing Chen, Qian Zhou, Gang Qi, Qiuhui Wang, Chunhua Ma, Chao Gu, Rui Wang, Mei Wang2026-08-28

🧬 biology

Metabolic Reprogramming and Temporal Immune Switching Coordinate Quantitative Resistance to Colletotrichum sublineola in Sorghum

This study reveals that quantitative resistance to sorghum anthracnose in resistant genotypes is driven by a coordinated strategy of metabolic reprogramming with reduced flavonoid accumulation, a catalase-centered antioxidant system, and a temporally regulated immune response that suppresses early pattern-triggered immunity before activating effector-triggered immunity via WRKY and HSF transcription factors.

Songshu Chen, Yuanpeng Fang, Yanqing Ding, Xiaojuan Liu, Kuiyin Li, Muhammad Arif, Mingjian Ren, Zhi Zhao, Xin Xie2026-08-28

🧬 biology

LncRNA NR_030777/DRP1 negatively regulates intercellular mitochondrial transfer in cobalt nanoparticles-induced neuronal damage

This study reveals that cobalt nanoparticles exacerbate neuronal damage by inducing lncRNA NR_030777 to upregulate DRP1, which inhibits protective tunneling nanotube-mediated mitochondrial transfer from neuroglioma to neurons.

Yilong Chen, Xiangyu Chang, Jiamei Li, Yilin Zhang, Xinpei Lin, Shangrong Jiang, Cheng Chen, Shengsong Lin, Ling Lin, Ju (…)2026-08-28

🧬 biology

Leading region anti-defense genes drive conjugation success of IncM and IncL plasmids

This study identifies a previously uncharacterized network of leading-strand anti-defense genes in IncM and IncL plasmids that are essential for overcoming recipient restriction enzymes and ensuring successful conjugation and the spread of antibiotic resistance.

Muhammad Kamruzzaman, Janani Jeyachandran, Jonathan Iredell2026-08-28

🧬 biology

Integrative single-cell and pan-cancer analyses identify LINC01871 and TBX21 as candidate regulators of antitumor T-cell immunity in breast cancer

By integrating single-cell and pan-cancer analyses, this study identifies an eight-gene CD8⁺ T-cell activity signature and highlights LINC01871 and TBX21 as critical regulators of antitumor immunity and promising therapeutic targets in breast cancer.

Xi Chen, Tao Tang, Wenyue Da, Tongbing Chen, Hui Wang, Pengyi Yu2026-08-28

🧬 biology

Genetic predisposition to schizophrenia and circulating proteins in 44,661 UK Biobank participants

This study analyzed 44,661 UK Biobank participants to identify significant associations between schizophrenia polygenic risk scores and specific circulating proteins, revealing both negative and positive links that may illuminate the biological pathways underlying schizophrenia and its comorbidities.

Rona Strawbridge, David McQueen, Kimberley Kendall, Jana Anderson, Francesco Casanova, Nina Fajs, Etsubdink Gebretsadik (…)2026-08-28

🧬 biology

MicroRNA Signatures: An Emerging Forensic Landscape for Body Fluids based Age Estimation

This review highlights the potential of microRNAs as stable, tissue-specific molecular biomarkers for forensic age estimation from trace biological evidence, while emphasizing the need for further validation and standardized methodologies before routine implementation.

Meenakshi Parmar, Kapil Verma, Bhawana Joshi2026-08-28

🧬 biology

Single-larva transcriptomics resolve phenotype-anchored Na+ K+ ATPase expression during first shell formation in Pacific oyster larvae under ocean acidification conditions

This study utilizes single-larva transcriptomics to demonstrate that Na+/K+ ATPase upregulation in Pacific oyster larvae under ocean acidification is specifically associated with successful first shell formation and localized to the shell hinge, rather than representing a generalized stress response in deformed individuals.

Marissa D. Wright-LaGreca, Karen D. Leask, Laura M. Parker, Timothy J. Green2026-08-28

🧬 biology

Paternal Origin and Subsequent Maternal Inheritance of a Novel FOXL2 Frameshift Variant Underlie Accelerated Ovarian Aging: A Three-Generation BPES-I Family Study

This study identifies a novel pathogenic FOXL2 frameshift variant in a three-generation Chinese family that, despite originating from a paternal grandfather, is transmitted maternally and causes accelerated ovarian aging and severe premature ovarian insufficiency through haploinsufficiency and disrupted folliculogenesis regulators.

Suping Li, Mengjiao Hu, Ru Xu, Qi Qi, Wenxin Chen, Na Jiang, Jiaqi Sun, Jianqiao Peng, Mingxin Jiang, Zizhe Wang, Erkai (…)2026-08-28

🧬 biology

Potential zoonotic transmission and environmental factors of Blastocystis sp. infection in wild roe deer (Capreolus capreolus) from Central Poland

This study of wild roe deer in Central Poland reveals a 32.5% prevalence of *Blastocystis* sp. (primarily subtypes ST14, ST13, and ST10), indicating a low zoonotic threat while demonstrating that infection probability is significantly influenced by landscape factors such as arable land and surface water, which increase risk, versus wind farms and settlements, which decrease it.

Joanna Korycińska, Małgorzata Lepczyńska, Marta Kloch, Marcin Świątek, Daniel Klich2026-08-28

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