1625 papers
The paper introduces ISPAT-3D, a hierarchical Bayesian framework that leverages 3D multiplexed tissue imaging to model spatially varying, zone-specific cell-type interaction networks, revealing volumetric immune-tumor dynamics and angiogenic remodeling patterns that are undetectable in traditional 2D analyses.
The study demonstrates that Senoversus, a dual-factor combination of CHIR99021 and bFGF, effectively rejuvenates both cellular and organismal aging by reversing epigenetic states and restoring transcriptional homeostasis, thereby extending lifespan and improving physiological function in mice.
This study demonstrates that silencing the deubiquitinating enzyme OTUB1 inhibits HepG2 liver cancer cell proliferation by promoting pyroptosis and inducing M1 macrophage polarization, thereby disrupting the tumor microenvironment.
This transdiagnostic study of 339 young adults reveals that heightened anhedonia-apprehension is uniquely associated with both reduced reward-related neural activity in the orbitofrontal cortex and ventral striatum, and unexpectedly heightened threat-related neural activity during fear extinction, underscoring the value of linking specific brain systems to empirically derived symptom dimensions.
This study provides the first detailed description of the reproductive biology of *Anastrepha dentata*, revealing that this Sapotaceae-associated fruit fly exhibits exceptionally delayed sexual maturation, complex multimodal courtship behaviors including lek formation, and unusually long copulation durations across contrasting environmental conditions in central Veracruz, Mexico.
This study demonstrates that mid-infrared spectroscopy combined with machine learning can rapidly and cost-effectively identify host species from dried blood meals of *Culex* mosquitoes, offering a scalable alternative to traditional methods for vector-borne disease surveillance, particularly in low-resource settings.
This paper presents a graph-based deep learning framework, specifically utilizing a Graph Transformer, that rapidly and accurately predicts patient-specific abdominal aortic aneurysm wall stress distributions from CTA-derived meshes, reducing inference time from hours to seconds while maintaining high fidelity to traditional finite element analysis.
This study reports a sequentially self-assembled supramolecular ternary complex that enables systemic delivery of Cas9 ribonucleoproteins to tumors, achieving efficient in vivo genome editing and significant tumor growth suppression by overcoming rapid clearance and enabling selective endosomal release.
This study demonstrates that long-term curling training induces a region-specific redistribution of resting-state prefrontal cortex activity in athletes compared to novices, characterized by decreased activity in planning regions, increased activity in decision-making and control regions, and a positive correlation between training duration and inhibition-related neural activity, thereby highlighting how strategic, low-load sports reshape the brain's functional organization.
This study utilizes a lattice model to demonstrate that while long-distance coral larval dispersal and global pathogen dispersal generally promote species coexistence by mitigating Janzen-Connell effects, the specific outcome in coral communities depends on complex interactions involving clonal growth, pathogen specificity, and size-dependent demographic rates.