3881 papers
This study reveals that mRNA-LNP vaccines induce tissue-resident fibroblasts at the injection site to acquire antigen-presenting cell properties, demonstrating that LNP composition directly shapes stromal cell function to modulate global immune responses.
This study establishes that kanamycin at a concentration of 25 mg/L is the minimal effective dose to inhibit shoot regeneration in both young and old *Lesquerella fendleri* leaf tissues, providing a critical baseline for developing transgenic lines of this oilseed crop.
This study demonstrates that baicalin inhibits *Escherichia coli* biofilm formation not by reducing bacterial viability, but by disrupting energy metabolism and redox balance to impair flagellar assembly and motility, thereby blocking early adhesion processes.
This study evaluates a post-hoc 36-gene epithelial module (M02) derived from FAP single-nucleus data, finding that while it shows consistent positive associations in independent FAP donors and some bulk datasets, it remains a selection-conditioned candidate rather than an independently validated sporadic-adenoma signature due to inherent design-time bias and limited external patient-level evidence.
This study reveals that pre-existing chronic hypertension in pregnant rats transforms the hypothalamic paraventricular nucleus's response from a subtle homeostatic adjustment into a massive transcriptomic reprogramming event, characterized by neuroimmune activation and autonomic dysfunction, which serves as an active counter-regulatory mechanism to sustain pregnancy despite elevated cardiovascular risk.
This study demonstrates that graded light exposure delivered specifically to the temporal visual field during central visual tasks elicits differentiated physiological, cognitive, and subjective responses, suggesting that regional melanopic spatial dose provides valuable information beyond traditional scalar light measures.
This study of 137 men demonstrates that muscle NAD(P) levels correlate more strongly with functional health and mitochondrial content than with chronological age, challenging the notion that obligatory NAD(P) depletion drives human muscle aging.
This study documents the first record of severe hypopigmentation, likely leucism, in a tiger shark (*Galeocerdo cuvier*) captured in the southwestern Atlantic Ocean, highlighting the value of fishery-dependent observations for identifying rare phenotypic traits in marine megafauna.
This study presents a structural-mechanical model demonstrating that while crown snow does not directly cause significant stress in buried *Fagus crenata* trunks, it amplifies snowpack-driven bending stress by altering trunk form through a hysteresis effect, thereby increasing the risk of snow damage under future wet-snow conditions.
This study demonstrates that a fully automated, no-repair receptor preparation protocol fails for 70% of high-resolution PDB structures primarily due to unresolved alternate conformers, revealing that such structural ambiguities constitute the dominant bottleneck in generating compatible receptors for reference-pose docking studies.