1625 papers
This study demonstrates that primary uterine leiomyoma cells rapidly lose their native molecular identity and drug responsiveness during standard 2D culture, necessitating the use of early-passage cells to ensure the reliability and translational relevance of in vitro pharmacological evaluations.
LNA-modified antisense gapmers targeting mutant TNPO3 partially restore molecular and cellular defects in LGMDD2 muscle cells by reducing pathogenic protein levels, demonstrating that even incomplete allele selectivity is sufficient to ameliorate key disease phenotypes.
This study demonstrates that CD4+ T cells are essential for driving HMBPP-induced Vγ9Vδ2 T cell expansion and anti-mycobacterial function in tuberculosis through the secretion of IL-2, a mechanism that is impaired in CD4+ T cell-deficient conditions such as HIV infection.
This study demonstrates that by integrating longitudinal fertility records, cross-breed modeling, and dimensionality-reduced SNP panels, attention-augmented genomic architectures can achieve high-accuracy discrimination between high- and low-fecundity sheep across breed boundaries, enabling early-life selection for prolificacy.
This study establishes a causal link between eosinophils and diabetic nephropathy using Mendelian randomization and identifies five key genes (IL7R, CD53, BPTF, FNBP4, and ANKRD36B) through integrated single-cell RNA sequencing analysis, offering potential targets for the diagnosis and treatment of the disease.
Researchers identified and characterized a novel PldB domain-containing esterase (PLR5) from a freshwater pond metagenome, which exhibits optimal activity on short-chain esters at 45°C and pH 8.0, along with significant solvent tolerance and a conserved catalytic triad, highlighting its potential for industrial biotransformation applications.
This study employs an integrated systems biology approach to identify distinct immune-related hub genes, specifically CXCL10, VCAM1, and CD40, as potential biomarkers and therapeutic targets for Epstein–Barr virus-positive intestinal-type gastric cancer.
This study establishes a human hematopoietic stem cell model of Congenital Dyserythropoietic Anemia Type II (CDAII) by knocking out the SEC23B gene, which successfully recapitulates the disease's characteristic erythroid differentiation defects, cell-cycle decoupling, and multinucleation, thereby providing a valuable platform for investigating pathophysiology and developing new therapies.
This study reveals the heterogeneous co-circulation of multiple DENV-1 and DENV-2 genotypes during Vietnam's 2023 outbreak, highlighting the critical need for whole-genome surveillance to monitor dengue diversity beyond simple serotype classification.
This study demonstrates that the South American grasshopper *Paramastax nigra* employs a deimatic display of vibrating white hindwings as a secondary defense mechanism, which is triggered at greater distances when its primary camouflage fails on unmatched backgrounds.